Abstract: An out of water swimming exercise device is described. An adjustable exercise bench is combined with a pedal mechanism for simulating arm motions and a stair climber mechanism for simulating leg motions. The pedal mechanism is rotated by telescopic cranks attached with universal joints and engaged by handgrips. The stair climber mechanism is pivoted by lever bars and engaged by the user's legs with cushioned rolls. Three different swim strokes can be simulated, including; freestyle, backstroke and butterfly. The exercise device is fully adjustable to different sizes of users. Accessory devices such as heart rate monitors, lap/distance counters, timers and the like can be attached to the device.

Abstract: A perceptual encoder divides an audio signal into successive time blocks, each time block is divided into frequency bands, and a scale factor is assigned to each of ones of the frequency bands. Bits per block increase with scale factor values and band-to-band variations in scale factor values. A preliminary scale factor for each of ones of the frequency bands is determined, and the scale factors for the each of ones of the frequency bands is optimized, the optimizing including increasing the scale factor to a value greater than the preliminary scale factor value for one or more of the frequency bands such that the increase in bit cost of the increasing is the same or less than the reduction in bit cost resulting from the decrease in band-to-band variations in scale factor values resulting from increasing the scale factor for one or more of the frequency bands.

Abstract: Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials possess coatings in the form of series of spaced apart bands, each band possessing a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer.

Abstract: A package for an electronic component includes a metal support substrate having a pattern of openings therethrough and a body of an insulating material, such as glass or ceramic, on and bonded to the surface of the support substrate. The body is formed from a plurality of layers of an insulating material, and conductive vias extending through the plurality of layers to the support substrate; said insulating body having an opening therein, an electronic component directly mounted in said opening to the patterned base plate. The base plate can be cut into one or more modules and directly soldered to a motherboard having additional devices mounted thereon.

Abstract: A class of imidazo[1,2-&agr;]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABAA receptors, in particular having good affinity for the &agr;2 and/or &agr;3 and/or &agr;5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

Abstract: A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-&agr;]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

Abstract: In this disclosure there is a method, system and a tool for analyzing e-channel data for a website and for applying the analytics for obtaining a rule based personalized website. The e-channel data is obtained, pre-processed and integrated. Different analytics are performed on the integrated data and reports are generated. In addition, this disclosure describes a marketing association tool for extracting useful rules from the pre-processed data and using the rules for enhancing the website dynamically and for generating decision support reports.

Abstract: Integrated packages incorporating multilayer ceramic circuit boards mounted on a metal support substrate can be used for temperature control by the metal support substrate. Various electronic components, as well as additional temperature control devices, can be connected to the circuit boards and to the metal support substrate to control or regulate the temperature of operation of the components. The integrated package can be hermetically sealed with a lid.

Abstract: The present invention provides a compound of formula (I) wherein A is an optionally substituted C1-4alkylidene group or a bond, R20 and R21 are hydrogen, alkyl groups or heterocyclic groups, R1 and R2 are small substituents or hydrogen, L is O, S or substituted N, X is a 5-or 6-membered heteroaromatic ring, Y is C1-4alkylidene and Z is a 5- or 6-membered heteroaromatic ring; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising it; its use in therapy; its use in making medicaments for treating neurodegenerative disease and methods of using it to enhance cognition.

Abstract: An indication of the loudness of an audio signal containing speech and other types of audio material is obtained by classifying segments of audio information as either speech or non-speech. The loudness of the speech segments is estimated and this estimate is used to derive the indication of loudness. The indication of loudness may be used to control audio signal levels so that variations in loudness of speech between different programs is reduced. A preferred method for classifying speech segments is described.

Abstract: A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, being selective ligands for GABAA receptors, in particular having good affinity for the &agr;2 and/or &agr;3 and/or &agr;5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

Abstract: The perceived quality of an audio signals obtained from very low bit-rate audio coding system is improved by using expanding quantizers and arithmetic coding in a transmitter and using complementary compression and arithmetic decoding in a receiver. An expanding quantizer is used to control the number of signal components that are quantized to zero and arithmetic coding is used to efficiently code the quantized-to-zero coefficients. This allows a wider bandwidth and more accurately quantized baseband signal to be conveyed to the receiver, which regenerates an output signal by synthesizing the missing components.

Abstract: The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a compound of formula I: 1

Abstract: A receiver in an audio coding system receives a signal conveying frequency subband signals representing an audio signal. The subband signals are examined to assess one or more characteristics of the audio signal. Spectral components are synthesized having the assessed characteristics. The synthesized spectral components are integrated with the subband signals and passed through a synthesis filterbank to generate an output signal. In one implementation, the assessed characteristic is temporal shape and noise-like spectral components are synthesized having the temporal shape of the audio signal.

Abstract: Audio coding processes like quantization can cause spectral components of an encoded audio signal to be set to zero, creating spectral holes in the signal. These spectral holes can degrade the perceived quality of audio signals that are reproduced by audio coding systems. An improved decoder avoids or reduces the degradation by filling the spectral holes with synthesized spectral components. An improved encoder may also be used to realize further improvements in the decoder.

Abstract: Solid oxide fuel cells made by coating a slurry of an electrolyte having a limited amount of organic material onto a carrier tape, depositing a one or two layer electrode material on the tape sufficient to support the electrolyte layer, removing the tape, screen printing a second electrode layer on the exposed surface of the electrolyte layer, and firing the layers at a temperature of 1100-1300° C. The resultant fired fuel cell can be mounted on an interconnector comprising a base plate, grooves formed in one face of the base plate, a porous conductive ceramic contact layer between the base plate and an overlying blocking layer of a porous conductive layer to provide electrical contact between the base plate and the blocking layer, or an interconnector having a fired green tape stack having conductive via contacts and air and gas flow channels formed therein. A sealing glass bonds the overlying layers to the base plate.

Abstract: An improved culture vessel or bioreactor for growing cells, cellular aggregates, tissue particles or tissue “organoids” and methods for using same which includes a housing having at least one chamber defined by a curved wall symmetrical about an axis. The perfused version of the vessel has at least one inlet and at least one outlet and at least one filter in fluid communication with at least one of the inlets or outlets structured to pass culture media but retain cells, cellular aggregates or tissues within the culture chamber. The batch culture version of the vessel has at least part of the vessel wall made of a gas permeable material. The vessel housing is rotated about the horizontal or proximate horizontal axis to suspend the cells, in an unobstructed, three-dimensional or toroidal flow. The chamber has a substantially ellipsoid, oblate ellipsoid, spherical or oblate spherical shape and an unobstructed volume for growth of cells, cellular aggregates or tissues.

Abstract: Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.

Abstract: An audio signal is conveyed more efficiently by transmitting or recording a baseband of the signal with an estimated spectral envelope and a noise-blending parameter derived from a measure of the signal's noise-like quality. The signal is reconstructed by translating spectral components of the baseband signal to frequencies outside the baseband, adjusting phase of the regenerated components to maintain phase coherency, adjusting spectral shape according to the estimated spectral envelope, and adding noise according to the noise-blending parameter. Preferably, the transmitted or recorded signal also includes an estimated temporal envelope that is used to adjust the temporal shape of the reconstructed signal.

Abstract: Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials possess coatings in the form of series of spaced apart bands, each band possessing a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer.