Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: A chiller includes an evaporator, a compressor including a prime mover, a first pressure sensor that detects a first pressure in the evaporator, a second pressure sensor that detects a second pressure in a condenser, and a controller. The controller determines a predicted energy level of the compressor based on the first pressure and the second pressure, the predicted energy level associated with liquid droplet flow into the compressor, compares the predicted energy level to an operating energy level, and modifies the at least one of the input power and the input current to the prime mover based on the comparison satisfying a modification condition.

Abstract: The present disclosure relates to systems and methods for collecting patient data via a monitoring system, with reduced power consumption. In one embodiment, the monitoring system is configured to emit pulses of light, and detect the light after passing through patient tissue. The light data is emitted sporadically, and a waveform is reconstructed from the sporadically sampled light data. Physiological parameters from the patient may be calculated from the reconstructed waveform. The sporadic sampling may reduce the power consumption by the monitoring system.

Abstract: A system is configured to determine a fluid responsiveness index of a patient from a physiological signal. The system may include a sensor configured to be secured to an anatomical portion of the patient, and a monitor operatively connected to the sensor. The sensor is configured to sense a physiological characteristic of the patient. The monitor is configured to receive a physiological signal from the sensor. The monitor may include an index-determining module configured to determine the fluid responsiveness index through formation of a ratio of one or both of amplitude or frequency modulation of the physiological signal to baseline modulation of the physiological signal.

Abstract: The present disclosure relates to systems and methods for collecting patient data via a monitoring system, with reduced power consumption. In one embodiment, the monitoring system is configured to emit pulses of light, and detect the light after passing through patient tissue. The light data is emitted sporadically, and a waveform is reconstructed from the sporadically sampled light data. Physiological parameters from the patient may be calculated from the reconstructed waveform. The sporadic sampling may reduce the power consumption by the monitoring system.

Abstract: A system is configured to determine a fluid responsiveness index of a patient from a physiological signal. The system may include a sensor configured to be secured to an anatomical portion of the patient, and a monitor operatively connected to the sensor. The sensor is configured to sense a physiological characteristic of the patient. The monitor is configured to receive a physiological signal from the sensor. The monitor may include an index-determining module configured to determine the fluid responsiveness index through formation of a ratio of one or both of amplitude or frequency modulation of the physiological signal to baseline modulation of the physiological signal.

Abstract: A system is configured to determine a fluid responsiveness index of a patient from a physiological signal. The system may include a sensor configured to be secured to an anatomical portion of the patient, and a monitor operatively connected to the sensor. The sensor is configured to sense a physiological characteristic of the patient. The monitor is configured to receive a physiological signal from the sensor. The monitor may include an index-determining module configured to determine the fluid responsiveness index through formation of a ratio of one or both of amplitude or frequency modulation of the physiological signal to baseline modulation of the physiological signal.

Abstract: According to various embodiments, a tracheal tube may employ sensing techniques for determining a distance between the inserted tube and an anatomical structure such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. Because a tracheal tube may rotate within the trachea, the sensing information may be gathered from multiple locations on the tracheal tube for a rotation-independent measurement technique.

Abstract: A system is provided including a thoracic bio-impedance or bio-reactance (TBIR) analysis module, a photoplethysmograph (PPG) analysis module, and a cardiac output module. The TBIR module is configured to obtain TBIR information from a TBIR detector, and the PPG analysis module is configured to obtain PPG information from a PPG detector. The cardiac output module is configured to determine the cardiac output of a patient using the TBIR information and the PPG information.

Abstract: Sensor designs or shapes to facilitate the placement of sensors on a patient are provided. For example, a first sensor may include a sensor body having a keyed interface region that is configured to align with a complementary keyed interface region of second sensor. Such sensors may also include various features to further facilitate the positioning of the sensors on the patient tissue and the positioning of the sensors with respect to one another. For example, the first sensor may include indicia relating to the second sensor having the complementary keyed interface region.

Abstract: The present disclosure relates to systems and methods for collecting patient data via a monitoring system, with reduced power consumption. In one embodiment, the monitoring system is configured to emit pulses of light, and detect the light after passing through patient tissue. The light data is emitted sporadically, and the patient physiological data is reconstructed from the sporadically sampled light data. The sporadic sampling may reduce the power consumption by the monitoring system.

Abstract: The present disclosure relates to systems and methods for collecting patient data via a monitoring system, with reduced power consumption. In one embodiment, the monitoring system is configured to emit pulses of light, and detect the light after passing through patient tissue. The light data is emitted sporadically, and a waveform is reconstructed from the sporadically sampled light data. Physiological parameters from the patient may be calculated from the reconstructed waveform. The sporadic sampling may reduce the power consumption by the monitoring system.

Abstract: A system is provided including a thoracic bio-impedance or bio-reactance (TBIR) analysis module, a photoplethysmograph (PPG) analysis module, and a cardiac output module. The TBIR module is configured to obtain TBIR information from a TBIR detector, and the PPG analysis module is configured to obtain PPG information from a PPG detector. The cardiac output module is configured to determine the cardiac output of a patient using the TBIR information and the PPG information.

Abstract: A sensor system is provided for determining a pulse transit time measurement of a patient. The sensor system includes a carotid sensor device configured to be positioned on a neck of the patient over a carotid artery of the patient. The carotid sensor device is configured to detect a plethysmograph waveform from the carotid artery. The sensor system includes a temporal sensor device that is operatively connected to the carotid sensor device. The temporal sensor device is configured to be positioned on the patient over a temporal artery of the patient. The temporal sensor device is configured to detect a plethysmograph waveform from the temporal artery.

Abstract: A system is provided including a ventilator detection module, a circulatory detection module, and an analysis module. The ventilator detection module is configured to detect ventilator information representative of a ventilation activity. The circulatory detection module is configured to detect circulatory information representative of the circulation of the patient. The analysis module is configured to obtain a ventilator waveform based at least in part on the ventilator information, obtain a circulatory waveform based at least in part on the circulatory information, combine the ventilator waveform and the circulatory waveform to provide a mixed waveform, and isolate a portion of the mixed waveform to identify a ventilator responsiveness waveform representative of an effect of the ventilator.

Abstract: A system is provided including a respiratory detection module, a circulatory detection module, and an analysis module. The respiratory detection module is configured to detect respiratory information representative of respiration of a patient. The circulatory detection module configured to detect circulatory information representative of circulation of the patient. The analysis module is configured to obtain a respiratory waveform based at least in part on the respiratory information, obtain a circulatory waveform based at least in part on the circulatory information, combine the respiratory waveform and the circulatory waveform to provide a mixed waveform, and isolate a portion of the mixed waveform to identify a respiratory responsiveness waveform representative of an effect of the respiration of the patient on the mixed waveform.

Abstract: A system is configured to determine a fluid responsiveness index of a patient from a physiological signal. The system may include a sensor configured to be secured to an anatomical portion of the patient, and a monitor operatively connected to the sensor. The sensor is configured to sense a physiological characteristic of the patient. The monitor is configured to receive a physiological signal from the sensor. The monitor may include an index-determining module configured to determine the fluid responsiveness index through formation of a ratio of one or both of amplitude or frequency modulation of the physiological signal to baseline modulation of the physiological signal.

Abstract: Systems and methods for applying optical signals into tissue of a patient are provided herein. In one example, a tissue interface system for applying optical signals to tissue of a patient is provided. The tissue interface system includes a tissue interface pad configured to apply the optical signals carried by at least one optical source into the tissue, and a pressurized volume configured to apply pressure to the tissue interface pad to couple a portion of the tissue interface pad to the tissue.

Abstract: A body-mounted photoacoustic sensor unit may use photoacoustic sensing to determine one or more physiological parameters of a subject. The body-mounted photoacoustic sensor unit may fixably locate a light source and photoacoustic detector relative to a target area. The photoacoustic detector may detect an acoustic pressure response generated by the application and absorption of light from the light source.