Patents by Inventor Mark T. Bilodeau

Mark T. Bilodeau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED CONSTRUCTS AND FORMULATIONS THEREOF
    Publication number: 20180296685
    Abstract: Targeted constructs and pharmaceutical formulations thereof, comprising at least one conjugate of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via an internal linker moiety have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. The internal linker may comprise a silicon-heteroatom core. Methods of making the targeted constructs and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 18, 2018
    Inventors: Richard Wooster, Mark T. Bilodeau
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
    Publication number: 20180273567
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
    Type: Application
    Filed: May 31, 2018
    Publication date: September 27, 2018
    Inventors: Mark T. Bilodeau, Benoît Moreau, Adam H. Brockman
  • COMPOSITIONS AND METHODS FOR GENOME EDITING
    Publication number: 20180258411
    Abstract: The present invention provides conjugates, nanoparticles and compositions comprising components of a CRISPR-Cas system; these compositions can be used for genetic editing in a cell or an organism.
    Type: Application
    Filed: September 23, 2016
    Publication date: September 13, 2018
    Inventors: Sudhakar Kadiyala, Mark T. Bilodeau, Donna T. Ward
  • PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
    Publication number: 20180243318
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.
    Type: Application
    Filed: June 22, 2016
    Publication date: August 30, 2018
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Richard Wooster, Benoît Moreau, Kerry Whalen, J. Michael Ramstack, Danielle N. Rockwood, Patrick Lim Soo, Sukhjeet Singh, Tsun P. Au Yeung, Charles-Andre Lemelin, Linda M. Custer
  • SSTR-TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20180221499
    Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
    Type: Application
    Filed: October 28, 2016
    Publication date: August 9, 2018
    Inventors: Richard Wooster, Kerry Whalen, Patrick Rosaire Bazinet, Mark T. Bilodeau, Sudhakar Kadiyala, Samantha Perino, Beata Sweryda-Krawiec, Rajesh R. Shinde
  • PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
    Publication number: 20180186823
    Abstract: The present teachings relate to compounds and compositions comprising a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or any moiety which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof. The platinum (IV) complex may comprise at least one active agent.
    Type: Application
    Filed: June 22, 2016
    Publication date: July 5, 2018
    Inventors: Sudhakar Kadiyala, Benoît Moreau, Mark T. Bilodeau, Kerry Whalen, Sukhjeet Singh, Richard Wooster, Charles-Andre Lemelin
  • Compounds, compositions, and methods for the treatment of cancers
    Patent number: 10011622
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: July 3, 2018
    Assignee: PLACON THERAPEUTICS, INC.
    Inventors: Mark T. Bilodeau, Benoît Moreau, Adam H. Brockman
  • Platinum compounds, compositions, and uses thereof
    Patent number: 9937187
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: April 10, 2018
    Assignee: PLACON THERAPEUTICS, INC.
    Inventors: Mark T. Bilodeau, Benoît Moreau, Adam H. Brockman, Kristan Meetze, Kerry Whalen, Richard Wooster, Rossitza G. Alargova
  • TARGETED CONJUGATES ENCAPSULATED IN PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20180021454
    Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: September 5, 2017
    Publication date: January 25, 2018
    Inventors: Mark T. Bilodeau, Sudhakar Kadiyala, Rajesh R. Shinde, Brian H. White, Richard Wooster, Benoît Moreau
  • Hexahydro-1H-4,7-methanoisoindole-1,3-dione compounds
    Patent number: 9867821
    Abstract: The present invention is directed to therapeutic agents which are atypical antipsychotics and which are useful in the treatment of neurological and psychiatric disorders associated with dopamine D2 and serotonin 5-HT2A neurotransmission dysfunction.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: January 16, 2018
    Assignees: SUMITOMO DAINIPPON PHARMA CO., LTD., MERCK SHARP & DOHME CORP.
    Inventors: Mark T. Bilodeau, Kausik K. Nanda, B. Wesley Trotter
  • PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
    Publication number: 20180008614
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
    Type: Application
    Filed: September 21, 2017
    Publication date: January 11, 2018
    Inventors: Mark T. Bilodeau, Benoît Moreau, Adam H. Brockman, Kristan Meetze, Kerry Whalen, Richard Wooster, Rossitza G. Alargova
  • TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20180000959
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: July 18, 2017
    Publication date: January 4, 2018
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
  • PLATINUM COMPOUNDS HAVING A HETEROCYCLE LIGAND, NANOPARTICLES, AND USES THEREOF
    Publication number: 20170349615
    Abstract: The present disclosure relates to novel platinum compositions having a heterocycle ligand and nanoparticles and methods using such compositions, e.g. for treating cancer.
    Type: Application
    Filed: August 24, 2017
    Publication date: December 7, 2017
    Inventors: Adam H. Brockman, Mark T. Bilodeau, Benoît Moreau, Edward R. Lee
  • TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20170312245
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
    Publication number: 20170313733
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one polar moiety as a ligand.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventors: Mark T. Bilodeau, Benoît Moreau
  • Platinum compounds having a heterocycle ligand, nanoparticles, and uses thereof
    Patent number: 9771387
    Abstract: The present disclosure relates to novel platinum compositions having a heterocycle ligand and nanoparticles and methods using such compositions, e.g. for treating cancer.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: September 26, 2017
    Assignee: PLACON THERAPEUTICS
    Inventors: Adam H. Brockman, Mark T. Bilodeau, Benoît Moreau, Edward R. Lee
  • Targeted conjugates and particles and formulations thereof
    Patent number: 9750818
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: September 5, 2017
    Assignee: TARVEDA THERAPEUTICS, INC.
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
  • Compounds, compositions, and methods for the treatment of cancers
    Patent number: 9738672
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one polar moiety as a ligand.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 22, 2017
    Assignee: PLACON THERAPEUTICS, INC.
    Inventors: Mark T. Bilodeau, Benoît Moreau
  • TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20170151339
    Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: June 30, 2015
    Publication date: June 1, 2017
    Inventors: Brian H. White, Rossitza G. Alargova, Patrick Rosaire Bazinet, Craig A. Dunbar, Patrick Lim Soo, Rajesh R. Shinde, Mark T. Bilodeau, Sudhakar Kadiyala, Richard Wooster, Timothy Barder, Kerry Whalen, James Gifford
  • TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20170095569
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: December 16, 2016
    Publication date: April 6, 2017
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster