Patents by Inventor Mark T. Dertzbaugh

Mark T. Dertzbaugh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies against ricin toxin and methods of making and using thereof
    Patent number: 7175845
    Abstract: Disclosed herein are monoclonal antibodies (Mabs) against ricin toxin and its subunits. The Mabs were initially selected based upon their ability to bind to ricin and its individual subunits in a solid-phase enzyme-linked immunoassay (ELISA). Several candidates were selected for further evaluation, including their ability to inhibit ricin intoxication in vitro and for their utility as immunodiagnostic reagents. As disclosed herein, the Mabs may be used in immunoassays. Also disclosed, are use of the Mabs to inhibit ricin-mediated eukaryotic cell cytotoxicity in vitro, thereby indicating that these Mabs may be used to prevent and treat ricin intoxication in vivo. Kits comprising the Mabs are also disclosed.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: February 13, 2007
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Mark T. Dertzbaugh
  • Botulinum neurotoxin vaccine
    Patent number: 6495143
    Abstract: Using the nontoxic heavy chain fragment from botulinum neurotoxins A-G, compositions and methods of use in inducing an immune response which is protective against intoxication with botulinum in subjects is described.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: December 17, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John S. Lee, Peter Pushko, Jonathan F. Smith, Michael Parker, Mark T. Dertzbaugh, Leonard Smith
  • BOTULINUM NEUROTOXIN VACCINE
    Publication number: 20020034521
    Abstract: Using the nontoxic heavy chain fragment from botulinum neurotoxins A-G, compositions and methods of use in inducing an immune response which is protective against intoxication with botulinum in subjects is described.
    Type: Application
    Filed: July 9, 1999
    Publication date: March 21, 2002
    Inventors: JOHN SCOTT LEE, PETER PUSHKO, JONATHAN F. SMITH, MICHAEL PARKER, MARK T. DERTZBAUGH, LEONARD SMITH
  • Protective peptides neurotoxin of C. botulinum
    Patent number: 6287566
    Abstract: Methods for developing vaccines to protect from neurotoxins of C. botulinum have been developed. Truncated BoNT/A proteins of about 15-30 kDa in size produced immune responses that provided protection from neuronal damage by botulinum neurotoxins.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: September 11, 2001
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Mark T. Dertzbaugh