Patents by Inventor Mark T. Miller

Mark T. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of ATP-binding cassette transporters
    Patent number: 8846753
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: September 30, 2014
    Assignee: Vertex Pharamaceuticals Incorporated
    Inventors: Sara S Hadida Ruah, Mark T. Miller, Brian Bear, Jason McCartney, Peter D. J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8741939
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: June 3, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • Work table having elevated support members
    Patent number: 8727327
    Abstract: A work table having elevated support members is disclosed. The work table includes a plurality of generally parallel support arrangements. Each of the plurality of generally parallel support arrangements including a plurality of raised portions, wherein the plurality of raised portions are distributed substantially evenly along each of the plurality of generally parallel support arrangements. Each of the plurality of raised blocks defines an opening configured for receiving an attachment. The work table also includes an adaptor plate. The adapter plate may include a base member and a plurality of inserts, wherein the plurality of inserts are spaced apart for insertion into a plurality of raised block openings to removably attach the adaptor plate to the work table.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: May 20, 2014
    Inventor: Mark T. Miller
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20140072995
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: November 14, 2013
    Publication date: March 13, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20140057906
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 27, 2014
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara S. Hadida Ruah, Peter D.J. Grootenhuis, Fredrick Van Goor, Jinglan Zhou, Brian Bear, Mark T. Miller, Jason McCartney, Mehdi Michel Jamel Numa, Xiaoqing Yang
  • Modulators of ATP-binding cassette transporters
    Patent number: 8642609
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: February 4, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Ashavini K. Singh, Mark T. Miller, Sarah S. Hadida Ruah, Peter D. J. Grootenhuis, Matthew Hamilton, Anna Ruth Hazlewood, Liming Huang
  • Modulators of ATP-binding cassette transporters
    Patent number: 8623905
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFFR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: January 7, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Peter D. J. Grootenhuis, Fredrick F. van Goor, Jinglan Zhou, Brian Bear, Mark T. Miller, Jason McCartney, Mehdi Michel Djamel Numa
  • Modulators of ATP-binding cassette transporters
    Patent number: 8598181
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: December 3, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Peter D. J. Grootenhuis, Fredrick Van Goor, Jinglan Zhou, Brian Bear, Mark T. Miller, Jason McCartney, Mehdi Michel Jamel Numa, Xiaoqing Yang
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20130296306
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: June 27, 2013
    Publication date: November 7, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara S Hadida Ruah, Mark T. Miller, Brian Bear, Jason McCartney, Peter D.J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8575209
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: November 5, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Peter D. J. Grootenhuis, Fredrick F. Van Goor, Jinglan Zhou, Brian Bear, Mark T. Miller, Jason McCartney, Mehdi Numa, Xiaoqing Yang
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20130252333
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP binding cassette transporters
    Patent number: 8524767
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: September 3, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark T. Miller, Sara S. Hadida Ruah, Brian R. Bear, Peter D. J. Grootenhuis, Jason McCartney
  • Work Table Having Elevated Support Members
    Publication number: 20130193283
    Abstract: A work table having elevated support members is disclosed. The work table includes a plurality of generally parallel support arrangements. Each of the plurality of generally parallel support arrangements including a plurality of raised portions, wherein the plurality of raised portions are distributed substantially evenly along each of the plurality of generally parallel support arrangements. Each of the plurality of raised blocks defines an opening configured for receiving an attachment. The work table also includes an adaptor plate. The adapter plate may include a base member and a plurality of inserts, wherein the plurality of inserts are spaced apart for insertion into a plurality of raised block openings to removably attach the adaptor plate to the work table.
    Type: Application
    Filed: March 13, 2013
    Publication date: August 1, 2013
    Inventor: Mark T. Miller
  • Modulators of ATP-binding cassette transporters
    Patent number: 8431605
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 30, 2013
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8415387
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: April 9, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Peter D. J. Grootenhuis, Mark T Miller, Jason McCartney, Fredrick van Goor, Mehdi Michel Djamel Numa, Jinglan Zhou, Brian Bear
  • Work table having elevated support members
    Patent number: 8403313
    Abstract: A work bench having elevated support members. The work bench may comprise a generally rectangular frame defined by two elongated members and two side members; a support base for supporting the generally rectangular frame in a generally horizontal plane; a plurality of cross members disposed in between the two side members, each of the plurality of cross members being generally parallel to the two side members and being coupled to the two elongated members; and a plurality of raised blocks located on top of each of the two side members and each of the plurality of cross members, wherein the plurality of raised blocks located on each of the two side members are distributed substantially evenly along each of the two side members, and the plurality of raised blocks located on each of the plurality of cross members are distributed substantially evenly along each of the plurality of cross members.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: March 26, 2013
    Assignee: Hagar Tools, Inc.
    Inventor: Mark T. Miller
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20120004216
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: July 1, 2011
    Publication date: January 5, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8039491
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: October 18, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Brian Bear, Jason McCartney, Peter D. J. Grootenhuis
  • Modulators of CFTR
    Patent number: 8012999
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: September 6, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Peter D. J. Grootenhuis, Jinglan Zhou, Brian Richard Bear, Mark T. Miller, Jason McCartney
  • Modulators of ATP-binding cassette transporters
    Patent number: 7973038
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: July 5, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark T. Miller, Peter D. J. Grootenhuis, Brian Richard Bear, Jason McCartney, Jinglan Zhou