Abstract: A hemostatic insert is provided for closing a puncture site in a blood vessel wall. The insert includes an expandable hemostatic member comprising a biocompatible water soluble gel configured to expand from a compressed state when exposed to body fluid and seal the puncture site in the blood vessel wall. A control layer surrounds the hemostatic member and delays expansion of the hemostatic member.

Abstract: Distal protection filter and method of using the same. A distal protection filter may be coupled to an elongate shaft. The filter includes a filter material coupled to a filter frame. The shape of the filter may be generally cylindrical or disc shaped. The filter material may capture embolic debris generated during an intravascular intervention.

Abstract: The present invention relates generally to systems and methods of enhancing recovery of function of injured tissue through administration of a composition comprising a relatively pure populations of B lymphocyte cells in a pharmaceutically acceptable carrier to the injured tissue. Kits are provided to aid in purification of B cells from heterogeneous mixtures of cells and administration of B cells to injured tissue.

Abstract: A closure device closes an opening in a body cavity. The closure device includes a plurality of fibrous tissue engaging members coupled to a proximally extending elongate member, a closure sheath sized to receive the elongate member and slidable over the elongate member to move the fibrous tissue engaging members from an expanded position to a collapsed position, a delivery sheath sized to receive the closure sheath and having a distal end sized to engage the fibrous tissue engaging members in the expanded position, and a closure member having an aperture sized to receive the closure sheath.

Abstract: The present invention relates generally to systems and methods of enhancing recovery of function of injured tissue through administration of a composition comprising a relatively pure populations of B lymphocyte cells in a pharmaceutically acceptable carrier to the injured tissue. Kits are provided to aid in purification of B cells from heterogeneous mixtures of cells and administration of B cells to injured tissue.

Abstract: A closure device closes an opening in a body cavity. The closure device includes a closure member that has an external, tissue-engaging surface formed with tissue engaging surface irregularities. An elongate member is disconnectably connected to the closure member.

Abstract: The present invention relates generally to systems and methods of enhancing recovery of function of injured tissue through administration of a composition comprising a relatively pure populations of B lymphocyte cells in a pharmaceutically acceptable carrier to the injured tissue. Kits are provided to aid in purification of B cells from heterogeneous mixtures of cells and administration of B cells to injured tissue.

Abstract: Distal protection filter and method of using the same. A distal protection filter may be coupled to an elongate shaft. The filter includes a filter material coupled to a filter frame. The shape of the filter may be generally cylindrical or disc shaped. The filter material may capture embolic debris generated during an intravascular intervention.

Abstract: A hemostatic insert is provided for closing a puncture site in a blood vessel wall. The insert includes an expandable hemostatic member comprising a biocompatible water soluble gel configured to expand from a compressed state when exposed to body fluid and seal the puncture site in the blood vessel wall. A control layer surrounds the hemostatic member and delays expansion of the hemostatic member.

Abstract: A closure device closes an opening in a body cavity. The closure device includes a closure member that has an external, tissue-engaging surface formed with tissue engaging surface irregularities. An elongate member is disconnectably connected to the closure member.

Abstract: Distal protection filter and method of using the same. A distal protection filter may be coupled to an elongate shaft. The filter includes a filter material coupled to a filter frame. The shape of the filter may be generally cylindrical or disc shaped. The filter material may capture embolic debris generated during an intravascular intervention.

Abstract: A method of performing a vascular closure whereby closure material is safely injected into the blood vessel and into the vascular opening.

Abstract: A method of performing a vascular closure whereby closure material is safely injected into the blood vessel and into the vascular opening.

Abstract: A method for inducing angiogenesis in blood vessels proximal to ischemic tissue or proximal to stenosed regions including application of an estrogen compound to the blood vessel walls at a treatment site proximal to or upstream of the stenosis. A preferred delivery device is a double walled drug delivery catheter having porous outer walls. Another suitable delivery device is a drug injection device for injecting angiogenic material into blood vessel walls. One delivery method utilizes iontophoresis.

Abstract: A method for inhibiting restenosis including local application of an oxidizing agent to blood vessel walls. Preferred oxidizing agents include peroxides, most preferably hydrogen peroxide. Oxidizing agents can be delivered utilizing drug delivery balloon catheters. Preferred delivery catheters include an inflatable balloon having a perfusion lumen therethrough to allow for longer application periods. Oxidizing agents can be delivered either alone or in conjunction with radiation or stent delivery. One method includes local delivery of 0.1% hydrogen peroxide to a dilated stenosis wall for a period of 10 minutes at a rate of 0.5 cc per minute.

Abstract: A method for inducing angiogenesis in blood vessels proximal to ischemic tissue or proximal to stenosed regions including application of an estrogen compound to the blood vessel walls at a treatment site proximal to or upstream of the stenosis. A preferred delivery device is a double walled drug delivery catheter having porous outer walls. Another suitable delivery device is a drug injection device for injecting angiogenic material into blood vessel walls. One delivery method utilizes iontophoresis.

Abstract: A training electrode for use in training emergency personnel in electrocardiogram (EKG) defibrillation and monitoring is disclosed. An adhesive pad is fixedly attached to a connector comprising a connecting post and a connecting arm. Attached to the connecting arm is an electrical cable with a female-type adaptor at its distal end for connection to an electrocardiogram simulation signal generator. The connecting post inserts into a female-type adaptor from a defibrillator/monitor cable lead originating from a defibrillator/monitor. A detachable backing covers an adhesive surface of the adhesive pad such that the training electrode may be reused. Further, a training method is disclosed using the training electrode of the present disclosure and incorporating existing CPR mannequins and EKG simulation signal generators.

Abstract: A defibrillation training system (10) is disclosed for use in training individuals in the proper positioning of defibrillation electrodes on a patient. The system includes a pair of training electrodes (12), each of which includes a permanent magnet (40). The training electrodes are attached to a manikin (14) at two electrode placement sites (42 and 44) provided with arrays (46 and 48) of Hall-effect sensors. The magnetic field produced by the permanent magnet in each electrode is sensed by the corresponding array, allowing an electrode placement monitor (16), attached to the manikin, to determine the electrodes' positions. The placement monitor then determines whether any adjustments in the electrodes' positions are required and prompts the individual being trained accordingly.