Abstract: An exhaust treatment arrangement includes a mixing assembly disposed between first and second substrates; and an injection mounting location disposed at the mixing assembly. The mixing assembly includes a mixing arrangement configured to direct exhaust flow exiting the first substrate in a swirling configuration, a restricting member defining a restricted passage, and optionally a dispersing member configured to even out the exhaust flow.

Abstract: Nasal cannulas for providing respiratory therapy to patients can have a curved prong section that has turbulation elements on the inside curve of the prong. A flow of breathing gas moving through the prong may incur less resistance and create less noise when flowing through such a prong due to the promotion of favorable flow dynamics.

Abstract: According to an aspect, there is provided a fall detection apparatus for detecting a fall by a user, the fall detection apparatus comprising a processing unit configured to: receive measurements of movements of the user over time from a first movement sensor that is to be worn or carried by the user; determine if any of one or more objects are being carried or used by the user; and determine whether the user has fallen by processing the received measurements of the movements of the user and measurements of movements of any object that is being carried or used by the user.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: The invention provides a surface analysis device for application to a receiving surface to enable analysis of at least one measure of an elasticity of said surface across multiple different linear stretches or sections of the surface. The device includes a two-dimensional arrangement of actuators and sensors, comprising at least one actuating element, at least one sensing element, and at least one further sensing or actuating element. Selected sets of two or more of these elements are activated together by a controller, each set including at least one actuator and one sensor, to thereby obtain a measure of elasticity between each actuator and sensor pair in the set. Elasticity measures are obtained based on stimulating a deformation in the receiving surface at the actuator site, and measuring a resultant pressure and/or force exerted by the receiving surface at a further displaced point. Sensors may monitor a change in the exerted pressure and/or force for example.

Abstract: Crystalline forms of Compound I: pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: An implantable device includes an EAP actuator and a sensor. The sensor is configured to monitor a force external to the implantable device acting in a direction either with or counter to a direction of actuation of the actuator, and a controller is adapted to control the actuator to actuate at a moment when force counter to the direction of actuation is sensed to be at its lowest within a given time window or force with the direction of actuation is sensed to be at its highest within a given time window. In this way, actuation is effected at a moment of least resistance force, reducing the power needed for deployment of the actuator, and permitting actuation to occur even in conditions experiencing large variable forces.

Abstract: The device as defined by the claims comprises electroactive polymer actuators (30) each of which is addressed by two addressing lines for selecting the electroactive polymer actuator and a current direction drive mode. A first circuit (42) is for driving a controllable current through the electroactive actuator in a first direction and a second circuit (44) is for driving a controllable current through the electroactive actuator in a second direction, opposite to the first direction. This device enables an actuator to be driven with current in two opposite directions so that the actuator may be driven bidirectionally between actuation states.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: An implantable blood flow control system has an open passageway defined inside a radially inner wall, behind which is a closed passageway. The radially inner wall includes electroactive polymer actuator members for providing a variable flow restriction. The flow restriction has an undulating shape so that the volume of the closed passageway may remain constant during actuation of the electroactive polymer actuator members. In this way, the chamber behind the actuator members does not impede free movement of the actuator members. The undulating pattern presents no sharp edges, where blood coagulation could otherwise occur.

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: The invention provides a power generation device comprising at least two generating arrangements, each adapted to generate a voltage output through the relative motion of two differently charged generating elements, the generating elements having some separation distance (which may be zero or non-zero). The arrangements are co-operatively configured in such a way that the separation distances between their respective elements are reciprocally related: an increase in one leads to a related decrease in the other. By combining these two signal outputs, a single voltage, current or power output may be provided in a self-regulating manner by the device whose amplitude is substantially independent of any changes or variations in the separation distance between elements of either of the two arrangements.

Abstract: An automated method and system for stacking and loading wrapped facemasks into a carton in a facemask production line include conveying individual wrapped facemasks to a delivery location adjacent to a rotary wheel, the rotary wheel conveyor having individual pick-up devices spaced around a circumference thereof. Each wrapped facemask is picked-up with a respective pick-up device on the rotary wheel conveyor and transported to a first carton staging area at a first location on the circumference of the rotary wheel. At the first staging area, the facemasks are released from the rotary wheel conveyor and deposited into a carton.

Abstract: A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material.

Abstract: A bowl assembly for a base driven appliance, the base driven appliance providing a primary drive coupling for the accessory assembly. The accessory assembly including: a bowl element that defines a reservoir; and a gear-box element having a secondary drive coupling and a secondary driven coupling. The bowl element defames a lower recess that removably receives the gear-box element, such that the primary drive coupling can engage the secondary driven coupling when the bowl assembly is supported by the base driven appliance. The secondary driven coupling is couplable to an accessory element that is operated within the reservoir, and such that the accessory element is operable by rotation of the primary drive coupling.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: The invention provides an electroactive material (preferably electroactive polymer) sensor system, comprising an electroactive material sensor (22) and a control system (28) for performing measurements relating to the impedance of the electroactive material sensor at at least first and second different frequencies. From these measurements a temperature at the sensor and an external pressure or force applied to the sensor can be determined. The sensor can thus be used as a pressure sensor and as a temperature sensor. When used in combination with actuation, an electroactive material actuator with integrated temperature sensing functionality is able to measure the temperature at the exact actuator position, which is always closer than an external thermocouple.

Abstract: A method for validating that an integrated circuit die is not susceptible to a conductive metallic ion diffusion defect is disclosed. A test component is applied to a backside surface of the integrated circuit die to form a test assembly. The test component includes a conductive metal layer and a transport media layer for facilitating diffusion of conductive metallic ions. The test assembly is heated at a thermal activation temperature. The integrated circuit die is computer validated to determine whether or not the integrated circuit die has the conductive metallic ion diffusion defect.

Abstract: Validating programming code by providing a data schema including registered data types, identifying a data object as defined according to a registered data type of the schema; and checking attempts to access the data object according to the registered data types of the data schema, at compile time.