Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants.

Abstract: Pie crust protector or pie shield for protecting the outer edge of a pie crust during baking is disclosed. The pie crust protector includes an annular section with a first flange segment and a second flange segment, each of which encompasses first grooves and first cut sections. The first grooves and the first cut sections allow each of the first flange segment and the second flange segment to easily flex and receive a pie and/or a pie pan. The pie crust protector includes a C-cross member segmented on the top and bottom sides. The annular section encloses the outer edge of the pie on three sides and the C-cross member encloses the remaining portion of the pie. The pie crust protector protects the outer edge of the pie during long bake times in standard or convection ovens, regardless of the location of a heating element.

Abstract: Pie crust protector or pie shield for protecting the outer edge of a pie crust during baking is disclosed. The pie crust protector includes an annular section with a first flange segment and a second flange segment, each of which encompasses first grooves and first cut sections. The first grooves and the first cut sections allow each of the first flange segment and the second flange segment to easily flex and receive a pie and/or a pie pan. The pie crust protector includes a C-cross member segmented on the top and bottom sides. The annular section encloses the outer edge of the pie on three sides and the C-cross member encloses the remaining portion of the pie. The pie crust protector protects the outer edge of the pie during long bake times in standard or convection ovens, regardless of the location of a heating element.

Abstract: A blast movement monitor for measuring the movement of material within a body of material as a result of a blasting operation, the monitor including: a housing having an interior chamber defining an inner surface; and an internal communication device that is received immediately within the interior chamber of the housing, the internal communication device including: a body portion; an electric coil wound around the body portion; a circuit board electrically connected to the coil; a battery electrically connected to the circuit board; an end portion associated with one end of the body portion; and a cap associated with an opposing end of the body portion that encapsulates the body portion and sealingly houses the body portion; wherein the internal communication device is biased to facilitate self-righting of the internal communication device to a desired orientation within the interior chamber independent of the orientation of the monitor.

Abstract: A dissection puzzle comprising a set of pieces, each piece in the set having an obverse face and a reverse face and a plurality of straight edges about said faces, and wherein said set of pieces may be formed into an assembled puzzle of straight-sided geometric shape by arranging the pieces in edge-to-edge abutting relationship, the form of the pieces being selected such that the area of each piece is selected from a set areas of different rational ratios to the area of the assembled puzzle and characterised in that: the obverse face and the reverse face of each piece include markings selected from a predetermined set of markings such that when arranged to form the assembled puzzle and viewed from one side, each edge of each piece adjacent another piece is adjacent a piece having a different marking.

Abstract: A blast movement monitor for measuring the movement of material within a body of material as a result of a blasting operation, the monitor including: a housing having an interior chamber defining an inner surface; and an internal communication device that is received immediately within the interior chamber of the housing and which is adapted to transmit a signal to an external communication device and/or to detect a signal transmitted by the external communication device; wherein the internal communication device includes a body portion and opposing end portions, the end portions being configured such that they are complementary with the inner surface of the interior chamber and the internal communication device being biased to facilitate self-righting of the internal communication device to a desired orientation within the interior chamber independent of the orientation of the monitor.

Abstract: A method for measuring the movement of boundaries between different portions of a heterogeneous rock body is disclosed. The method comprises placing a plurality of blast movement monitors 109 in a rock body prior to blasting and noting the position of each blast movement monitor. The rock body is then blasted to break it up into a plurality of pieces. Thereafter the position of the blast movement monitors 109 is located and based on this the boundaries of rock portions can be adjusted to account for the blast. This leads to a more accurate reporting of different ore bodies to the appropriate processor in a heterogeneous rock body. An apparatus for carrying out the method is also disclosed. The apparatus comprises broadly a said monitor 109 and a receiver. The monitor 1 comprises a transmitter 109 received within a casing 111 that in turn is received within a housing 126. Further the casing 111 can move within the housing 126 and self right so that it always transmits its signal in an upright direction.

Abstract: A method for measuring the movement of boundaries between different portions of a heterogeneous rock body is disclosed. The method comprises placing a plurality of blast movement monitors 109 in a rock body prior to blasting and noting the position of each blast movement monitor. The rock body is then blasted to break it up into a plurality of pieces. Thereafter the position of the blast movement monitors 109 is located and based on this the boundaries of rock portions can be adjusted to account for the blast. This leads to a more accurate reporting of different ore bodies to the appropriate processor in a heterogeneous rock body. An apparatus for carrying out the method is also disclosed. The apparatus comprises broadly a said monitor 109 and a receiver. The monitor 1 comprises a transmitter 109 received within a casing 111 that in turn is received within a housing 126. Further the casing 111 can move within the housing 126 and self right so that it always transmits its signal in an upright direction.

Abstract: A game or puzzle comprising a plurality of polyomino pieces, each piece having on opposite faces one or more squares, said squares on each said piece and on opposite faces having markings wherein such said markings of said squares in total on both faces of said pieces comprise four or more different markings such that the pieces are capable of being assembled using their obverse faces only into a first set of one pattern comprising squares with the markings of the squares on the obverse faces of the assembled pieces forming a checkerboard pattern of two alternating markings which may be used for playing a checkers or chess type game, and the pieces may be further assembled into a second set of one or more patterns using the reverse faces of some of the pieces and the obverse faces of the remaining pieces, each pattern in the second set comprising squares forming a further checkerboard pattern of four or more markings, one of said markings being in an alternating checkerboard pattern with the remaining marking

Abstract: A method for preparing ketones in greater yield and selectivity compared to previous catalyzed reactions by acid-catalyzed condensation reaction using a metal-doped polysulfonated ion exchange resin catalyst is disclosed. For example, use of polysulfonated ion exchange resins having at least 5.0 milliequivalents sulfonic acid groups/gram catalyst and loaded with metal, such as palladium, provides enhanced yields of methyl isobutyl ketone from the condensation reaction of acetone compared to use of conventional monosulfonated ion exchange resin catalysts.

Abstract: A game or puzzle comprising a plurality of polyomino pieces, each piece having on opposite faces one or more squares, said squares on each said piece and on opposite faces having markings wherein such said markings of said squares in total on both faces of said pieces comprise four or more different markings such that the pieces are capable of being assembled using their obverse faces only into a first set of one pattern comprising squares with the markings of the squares on the obverse faces of the assembled pieces forming a checkerboard pattern of two alternating markings which may be used for playing a checkers or chess type game, and the pieces may be further assembled into a second set of one or more patterns using the reverse faces of some of the pieces and the obverse faces of the remaining pieces, each pattern in the second set comprising squares forming a further checkerboard pattern of four or more markings, one of said markings being in an alternating checkerboard pattern with the remaining marking

Abstract: Washed cleavage product (WCP) in a phenol manufacturing process is treated to remove sodium ions. The WCP is contacted with a cation exchange resin in hydrogen form, and then with anion exchange resin in free base or hydroxide form, to produce a WCP essentially free of sodium ions. The cation and anion exchange resins are regenerated with acid and caustic, respectively. The treatment improves productivity and product quality of new and existing phenol processes.

Abstract: Washed cleavage product (WCP) in a phenol manufacturing process is treated to remove sodium ions. The WCP is contacted with a cation exchange resin in hydrogen form, and then with anion exchange resin in free base or hydroxide form, to produce a WCP essentially free of sodium ions. The cation and anion exchange resins are regenerated with acid and caustic, respectively. The treatment improves productivity and product quality of new and existing phenol processes.

Abstract: A fishing lure has a hollow body that contains a battery and a selected recipient device (eg. a light emitting device, horn, vibrator motor). A switch interrupts a circuit to deactivate the light emitting device (or other recipient device) when the lure body is moved from a generally horizontal, “swimming” position to a more inclined position. The apparatus has a rechargeable battery that can be charged by connecting to hook eyelets on the lure body.

Abstract: A method for preparing ketones in greater yield and selectivity compared to previous catalyzed reactions by acid-catalyzed condensation reaction using a metal-doped polysulfonated ion exchange resin catalyst is disclosed. For example, use of polysulfonated ion exchange resins having at least 5.0 milliequivalents sulfonic acid groups/gram catalyst and loaded with metal, such as palladium, provides enhanced yields of methyl isobutyl ketone from the condensation reaction of acetone compared to use of conventional monosulfonated ion exchange resin catalysts.

Abstract: A game or puzzle including a plurality of polyomino pieces which have the obverse sides and the reverse sides marked with different markings, there being a least three markings in total on the obverse and reverse sides of the piece. The pieces may be assembled using both sides into different arrays of eight by eight squares defining checkerboard patterns for use in playing the game of chess or checkers. The pieces may also be assembled into a cube comprising four by four squares.