Abstract: A configurable fluid delivery system and methods for its use are disclosed. The system may include one or more control units, fluid delivery units, fluid actuator units, and disposable units. Data sources and sensors on each of the delivery units, actuator units, and disposable units may provide data to the control unit, thereby identifying the components along with the manner in which they may be configured. The control unit may notify a user regarding the status of any one or more of the delivery, actuator, and disposable units to indicate their appropriateness for delivering a fluid according to one or more selected procedures and protocols. Also disclosed are methods by which the configurable fluid delivery unit may provide data to a user to assist the user in assembling and testing a particular fluid delivery configuration for a specific use.

Abstract: A syringe for use with an injector includes a body having a rear end and a front end, a plunger movably disposed within the body, an attachment member associated with the body and adapted to releasably engage a syringe retaining mechanism of the injector regardless of the orientation of the syringe with respect to the injector, and an encoding device operable to provide syringe information to the injector.

Abstract: Systems and methods for enabling high fluid rate injections are disclosed. The system includes a hollow dip tube, an introducer and a sharp tip-end. The introducer has a hollow sleeve that includes an opening at a proximal end. The sharp-tip end is located at a distal end of the introducer and is configured to pierce a septum of a container. The introducer is configured to receive the dip tube through the opening. Fluid may be withdrawn from the container through the dip tube upon insertion. In some cases, the dip tube separates the tip-end from the introducer when it is inserted through the opening. In other cases, the tip-end remains seated in the introducer and allows fluid to pass through it as it is withdrawn from the container.

Abstract: Bent syringes, mounting systems for bent syringes, and devices incorporating bent syringes are described herein. The syringes include a bent cylindrical body bent about a radius and a plunger bent about the radius of the bent cylindrical body and configured and arranged to be received by the proximal open end of the bent cylindrical body and movably disposed within at least a portion of the bent cylindrical body.

Abstract: A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

Abstract: A syringe for use with an injector includes a body having a rear end and a front end, a plunger movably disposed within the body, an attachment member associated with the body and adapted to releasably engage a syringe retaining mechanism of the injector regardless of the orientation of the syringe with respect to the injector, and an encoding device operable to provide syringe information to the injector.

Abstract: A syringe system and components thereof are disclosed. The system may include a syringe body having a hollow lumen, a proximal open end, and a distal end. The syringe body may be configured to house a fluid therein. The syringe system may further include a plunger positioned in the hollow lumen of the syringe body, forming a seal with an inner wall of the syringe body. The plunger may include a removable piston having a shaft extending from the distal end towards the proximal open end, a stopper removably connected to a distal portion of the shaft, and at least one coupler attached to the distal portion of the shaft. The stopper may be configured to slidably move within the hollow lumen to facilitate movement of the fluid within the syringe body. The coupler may be configured to facilitate removal and attachment of the stopper from the piston.

Abstract: A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.

Abstract: A syringe shield used for containing radioactive drugs in order to reduce healthcare provider's exposure to radiation or to reduce or eliminate ambient light contamination to optically sensitive components in a syringe.

Abstract: A bellows assembly for a fluid delivery system is a multi-component device that includes a cylindrical pressure jacket and a bellows syringe that is received within the pressure jacket. The bellows syringe includes a cap member and a bellows member. The bellows syringe in one embodiment is adapted to be secured to the pressure jacket by the cap member. The cap member is formed with a discharge port, which may be formed as conventional luer fitting. The discharge port is disposed coaxially within an annular wall on the outward facing side of the cap member and may be recessed within the annular wall. The bellows member is a hollow body that includes a series of bellows sections or rings. A distal end of the bellow member is formed with a discharge neck terminating in a discharge port, and the proximal end is formed with a closed end wall.

Abstract: A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

Abstract: A system for delivering a slurry to a patient includes a fluid, a material that is non-dissolvable or immiscible in the fluid, thereby forming a slurry, a container adapted to contain the slurry and a supernate of the slurry, the container defining an outlet through which the slurry is delivered to the patient, a fluidizing system associated with the container, a pressurizing mechanism adapted to create a pressure to cause the slurry contained within the container to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system and the pressurizing mechanism. The fluidizing system is adapted to effect dilation of the slurry while maintaining at least a portion of the supernate.

Abstract: A displacement syringe having a housing with a distal tip and a proximal end; a moveable outer plunger within the housing having an elongated passageway; at least one moveable inner plunger within the passageway of the outer plunger; at least one first seal between the outer plunger and the housing; and at least one second seal between the inner plunger and the outer plunger is disclosed herein. The syringe may have a lock at the proximal end of the housing and/or a valve at the distal tip of the housing. The syringe may also have a plurality of inner plungers of various diameters. A transfer system and delivery system are also disclosed herein. Methods to accurately and efficiently deliver small volumes using the displacement syringe are also disclosed.

Abstract: A system for processing cells is disclosed. The system may include a container having an inner wall, a plunger adapted to be slidably positioned within the container, at least one inlet port through which a fluid can enter the container, at least one outlet port through which a fluid can exit the container, at least one effluent port through which an effluent can exit the container, a first check valve in fluid connection with the inlet port and a second check valve in fluid connection with the effluent port. The plunger may include a filter that allows fluid to pass therethrough but prevents cells from passing therethrough. Rearward motion of the plunger may be adapted to draw fluid into the system via the inlet port and forward motion of the plunger may be adapted to force effluent out of the system via the effluent port.

Abstract: A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movemen

Abstract: A valve system for use in a system including a first source of a first pressurized fluid and a second source of a second pressurized fluid includes a valve housing including a first inlet port adapted to be placed in fluid connection with the first source, a second inlet port adapted to be placed in fluid connection with the second source and an outlet port. The valve system further includes a backflow prevention system to prevent flow of the first pressurized fluid through the second inlet and to prevent flow of the second pressurized fluid through the first inlet port. The valve system is adapted to provide a fluid path between at least the first inlet port and the outlet port to enable fluid to be drawn from the outlet port to the first inlet port. Several of the valve systems of the present invention provide for flow from the first inlet port to the outlet port and concurrent flow from the second inlet port to the outlet port.

Abstract: A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.

Abstract: A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

Abstract: A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system.

Abstract: A battery charger system, for use with an injector system, comprises a power supply and a battery pack. The power supply converts AC power to DC power. The battery pack includes a battery and a charging module. The module monitors the operating mode of the injector system. When the battery pack is disconnected from the injection control unit, the module enables the power supply to charge the battery with DC power. When the battery pack is connected to the injection control unit: (A) upon detecting the injector system in an idle mode, the module routes DC power from the power supply to both the battery for charging thereof and the injection control unit for operation thereof; and (B) upon detecting the injector system in a non-idle mode, the module prevents the power supply from charging the battery and enables the battery to provide DC power to the injection control unit.