Abstract: Various examples are provided related to bimodal electron paramagnetic resonance (EPR). In one example, a bimodal resonator includes a detection coil; first and second excitation coils, where the excitation coils are non-parallel separated by a fixed angle; and excitation controllers coupled to the first and second excitation coils. The excitation controllers can adjust radio frequency (RF) fields generated by the first and second excitation coils to produce a resonator field substantially parallel with the detection coil. In another example, a method including generating a first RF field by exciting the first excitation coil; generating a second RF field by exciting the second excitation coil; and producing a resonator field substantially parallel with a detection coil of the bimodal resonator by adjusting the RE field of the first excitation coil, the RF filed of the second excitation coil, or both.

Abstract: Described herein are positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) systems and methods of use. In one example, a PET-EPRI system includes a PET-EPR insert, a PET scanner including one or more solid-state photodetectors, and a subject module that can house a subject for scanning. The PET-EPR insert includes an EPR resonator that can nest inside the PET scanner. The EPR resonator includes a resonator that can receive the subject module, a shield encircling the resonator and one or more rapid scan coils (RS-coils) positioned around the shield. The shield can prevent electrical coupling between the RS-coils and the resonator while being transparent to annihilation photons and magnetic field scans.

Abstract: Full-cycle rapid scan (RS) electron paramagnetic resonance (EPR) can be performed without the instability of prior art methods and with a higher scan rate than traditional half-scan methods. In particular, a full scan is performed, but the constant RF driving B-field can be mathematically represented as two step functions, each corresponding to one half of a full scan cycle. This mathematical representation can be carried through the deconvolution such that two deconvolutions, one for the up cycle and one for the down cycle, can be performed. The solutions to these two deconvolutions can then be summed to give a single spectrum having a higher signal-to-noise ratio than half-cycle RS scans.

Abstract: Described herein are PET-EPRI systems and methods of use.

Abstract: Full-cycle rapid scan (RS) electron paramagnetic resonance (EPR) can be performed without the instability of prior art methods and with a higher scan rate than traditional half-scan methods. In particular, a full scan is performed, but the constant RF driving B-field can be mathematically represented as two step functions, each corresponding to one half of a full scan cycle. This mathematical representation can be carried through the deconvolution such that two deconvolutions, one for the up cycle and one for the down cycle, can be performed. The solutions to these two deconvolutions can then be summed to give a single spectrum having a higher signal-to-noise ratio than half-cycle RS scans.