Abstract: An exchange hub having electronic connections to subscribers including prescribers, pharmacies and pharmacy benefit management services (PBMs) for the purpose of exchanging relevant pharmaceutical data is disclosed. The, exchange hub allows each of its subscribers to send communications that may include request and response transactions, an end point to end point message, or an upload of a data file. The communications may be opaque to the exchange hub or the contents may be modified for additional value. The communications may include a request for eligibility of benefits for a particular patients which will return an aggregation of all PBMs for which that patient is eligible. Additional patient information such as formularies or medication history may be requested. The exchange hub also may route prescription information between the prescriber and pharmacies.