Patents by Inventor Mark V. Cleve

Mark V. Cleve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of nucleic acids in cells by thermophilic strand displacement amplification
    Patent number: 5631147
    Abstract: Thermophilic Strand Displacement Amplification (tSDA) for amplification of nucleic acid target sequences in situ in cells in suspension, on slides or in tissues is described. Excellent specimen morphology is preserved, and either DNA targets, RNA targets, or both may be selectively amplified. In situ amplification by tSDA is compatible with immunochemical techniques, so that both amplification of target sequences and immunological staining can be performed on the same specimen.
    Type: Grant
    Filed: September 21, 1995
    Date of Patent: May 20, 1997
    Assignee: Becton, Dickinson and Company
    Inventors: Kenton L. Lohman, Natalie V. Ostrerova, Mark V. Cleve, Robert A. Reid