Abstract: The present invention relates generally to methods for preparing mechanically macerated demineralized bone materials that are useful in, or as, implants having a variety of orthopedic applications. More particularly, the demineralized bone materials prepared according to the present invention comprise web-like sections that are compression- and extrusion-resistant and thus, suitable for use in, or as, bone implants or bone grafting materials. Additionally, the web-like morphology increases the surface area of the graft and thereby facilitates the rehydration of the graft, should it be freeze dried. The increased surface area also allows for increased contact with autologous growth factors. The present invention further relates to the demineralized bone materials prepared by the disclosed methods and compositions comprising the same. Methods for preparing a bone void for orthopedic applications, such as bone implants, using the demineralized bone materials or compositions thus prepared are also provided.

Abstract: A cannulated medical instrument for insertion of a medical device over a guide wire generally includes a cannulated driver member configured to engage the medical device and insert the medical device at an insertion rate. A clasping device connects to the cannulated driver member. The clasping device moves the guide wire distally away from the cannulated driver member at an extraction rate upon rotation of the cannulated driver member.

Abstract: Long bone fracture fixation systems, and methods for using same, are described. The systems primarily include an intramedullary nail having an elongated throughbore and a first slot for receiving transcortical screws and another slot for receiving an insert. A modular sleeve having a throughbore and a pair of openings for receiving transcortical screws and another pair of dissimilarly shaped openings for receiving the insert are placed over the proximal portion of the intramedullary nail. The modular sleeve can be provided with various opening patterns for receiving transcortical screws at various angles relative to the intramedullary nail. The insert is then properly positioned and is held in place by a hollow set screw disposed within, and coaxial to, the throughbore of the intramedullary nail. In this manner, the throughbore of the intramedullary nail is unobstructed, thus allowing instrumentation to be freely inserted through the entire length of the throughbore.

Abstract: Long bone fracture fixation systems, and methods for using same, are described. The systems primarily include an intramedullary nail having an elongated throughbore and a first slot for receiving transcortical screws and another slot for receiving an insert. A modular sleeve having a throughbore and a pair of openings for receiving transcortical screws and another pair of dissimilarly shaped openings for receiving the insert are placed over the proximal portion of the intramedullary nail. The modular sleeve can be provided with various opening patterns for receiving transcortical screws at various angles relative to the intramedullary nail. The insert is then properly positioned and is held in place by a hollow set screw disposed within, and coaxial to, the throughbore of the intramedullary nail. In this manner, the throughbore of the intramedullary nail is unobstructed, thus allowing instrumentation to be freely inserted through the entire length of the throughbore.