Patents by Inventor Mark Varney
Mark Varney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7884124Abstract: This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O?X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.Type: GrantFiled: July 2, 2007Date of Patent: February 8, 2011Assignee: Sepracor Inc.Inventors: Michele L. R. Heffernan, Robert J. Foglesong, Seth C. Hopkins, Mustapha Soukri, Steven W. Jones, Kerry L. Spear, Mark A. Varney
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Publication number: 20100264042Abstract: A method of determining the general or a specific condition of a subject is disclosed, the method comprising measuring the concentration of each of a plurality of components in a single sample of the gas stream exhaled by the subject; and generating information regarding the concentration of each of the plurality of components such that the concentrations of the components are directly comparable. The method is particularly suitable for assessing the condition of the respiratory system of a subject. The method preferably employs electrochemical sensors to measure the concentration of the target components in the exhaled gas stream.Type: ApplicationFiled: October 24, 2008Publication date: October 21, 2010Applicant: ANAXSYS TECHNOLOGY LTDInventors: Mark Varney, Michael Garrett
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Publication number: 20100190861Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.Type: ApplicationFiled: January 15, 2010Publication date: July 29, 2010Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Larry R. Bush, Jianguo Ma, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, John E. Campbell
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Publication number: 20100175699Abstract: A sensor assembly for monitoring the respiration pattern of a subject is disclosed, the sensor comprising a sensor element for exposing to a gas stream exhaled by the subject comprising a first electrode, a second electrode and an active layer extending between the first and second electrodes to provide an electrical path therebetween, the sensor element being responsive to the concentration of water vapour in the gas stream exhaled by the subject, whereby the conductivity of the path between the electrodes varies in response to changes in the concentration of water vapour; a processor for determining the pattern of respiration of the subject; and means for displaying information relating to the determined respiration pattern to a user. The sensor assembly is particular suitable for measuring the respiration rate and/or depth of respiration of the subject. The sensor and method find particular application in the diagnosis and treatment of sleep apnea.Type: ApplicationFiled: April 10, 2008Publication date: July 15, 2010Applicant: ANAXSYS TECHNOLOGY LTDInventors: Mark Varney, Michael Garrett, Deryk Williams, John Beadle
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Publication number: 20100133120Abstract: An electrochemical sensor (40) is provided, the sensor comprising a working electrode (44); a counter electrode (46); and an ionic liquid medium extending between the working electrode and the counter electrode, the ionic liquid medium comprising an ionic liquid retained in a support material. The ionic liquid may comprise a cation selected from 1-alkyl-3-methylimidazolium ([CnMIM]), N-alkylpyridinium, tetraalkylammonium or tetraalkylphosphonium cations and an anion selected from hexafluorophosphate [PF6]; tetrafluoroborate [BF4]; trifluoromethylsulfonate [CF3SO3]; bis[(trifluoromethyl)sulfonyl]amide [(CF3SO2)2N]; trifluoroethanoate [CF3CO2]; acetate [CH3CO2]; nitrate, and halides, including fluoride [F] 1 chloride [Cl], and bromide [Br]. The sensor is particularly useful in the detection of gaseous components in the exhaled breath of a subject and for use in monitoring the lung function of the subject, for example to identify the onset of asthma and/or COPD.Type: ApplicationFiled: March 17, 2008Publication date: June 3, 2010Applicant: ANAXSYS TECHNOLOGY LTDInventors: Mark Varney, Micheal Garrett, Deryk Williams, Francis Marken
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Publication number: 20100050735Abstract: A sensor for sensing a target substance in a gas stream is provided, the sensor comprising: a sensing element disposed to be exposed to the gas stream, the sensing element comprising: a working electrode; a counter electrode; and a layer of ion exchange material extending between the working electrode and the counter electrode; whereby contact of the ion exchange layer with the gas stream forms an electrical contact between the working and counter electrodes.Type: ApplicationFiled: July 20, 2007Publication date: March 4, 2010Inventors: Mark Varney, Michael Garrett
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Publication number: 20090272656Abstract: A method for the determination of the carbon dioxide content of an exhaled gas stream is provided, the method comprising measuring the water vapour content of the exhaled gas stream, and determining the concentration of carbon dioxide in the exhaled gas stream from the measured water vapour content. A particular method comprises causing the gas stream to impinge on a sensing element comprising a working electrode and a counter electrode; applying an electric potential across the working electrode and counter electrode; measuring the current flowing between the working electrode and counter electrode as a result of the applied potential; and determining from the measured current flow an indication of the concentration of the water vapour in the gas stream. A sensor is also described.Type: ApplicationFiled: October 17, 2007Publication date: November 5, 2009Inventors: Mark Varney, Michael Garrett, Deryk Williams
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Publication number: 20090111817Abstract: One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is an antidepressant. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.Type: ApplicationFiled: July 5, 2006Publication date: April 30, 2009Applicant: SEPRACOR INC.Inventors: Judy Caron, Thomas Wessel, Karim Lalji, Mark A. Varney
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Publication number: 20090111818Abstract: One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is O-desmethylvenlafaxine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.Type: ApplicationFiled: July 5, 2006Publication date: April 30, 2009Applicant: SEPRACOR INC.Inventors: Judy Caron, Thomas Wessel, Karim Lalji, Mark A. Varney
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Publication number: 20090054798Abstract: An apparatus for monitoring the respiration of a subject, the apparatus comprises means for detecting the concentration of each of oxygen, carbon dioxide and nitric oxide in an inspired and/or exhaled gaseous stream of a subject; and a display for displaying the concentration of each of oxygen, carbon dioxide and nitric oxide. A method for monitoring the respiration of a subject comprises analysing the composition of the inspired and/or exhaled gas of the subject and determining the concentration of carbon dioxide, oxygen and nitric oxide in the gas; and displaying the results of the analysis on a display to provide an indication of the respiratory state of the subject. A method of determining the extent of resuscitation of a patient comprises measuring the concentration of carbon dioxide, oxygen and nitric oxide in the inspired gas stream and/or exhaled gas stream of the subject.Type: ApplicationFiled: November 22, 2005Publication date: February 26, 2009Applicant: ASTHMA ALERT LIMITEDInventors: Mark Varney, Michael Ernest Garrett, Deryk Williams
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Publication number: 20090005456Abstract: Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.Type: ApplicationFiled: June 2, 2008Publication date: January 1, 2009Applicant: SEPRACOR INC.Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Jianguo Ma, Seth Ribe, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, Rudy Schreiber, Kerry L. Spear
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Publication number: 20080293726Abstract: One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.Type: ApplicationFiled: July 6, 2006Publication date: November 27, 2008Applicant: SEPRACOR INC.Inventors: Judy Caron, Thomas Wessel, Karim Lalji, Mark A. Varney, Roger P. Bakale, Surendra P. Singh, H. Scott Wilkinson, Xiping Su, Zhengxu Steve Han, Stefan G. Koenig
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Publication number: 20080175903Abstract: The present disclosure provides a unit dosage form with an anxiolytic dosage of zopiclone particularly eszopiclone. Also provided is a method for treatment or prophylaxis of anxiety using a subsedative dosage of zopiclone particularly eszopiclone.Type: ApplicationFiled: December 1, 2007Publication date: July 24, 2008Applicant: Sepracor Inc.Inventors: Seth C. Hopkins, Mark A. Varney, Tushar Misra, Gary Maier, Judy Caron, Randall S. Wagner
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Publication number: 20080058395Abstract: This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein Q is a member selected from O, S, CR1 and N, X and Y are members independently selected from CR2, O, S, N and NR3.Type: ApplicationFiled: July 2, 2007Publication date: March 6, 2008Applicant: SEPRACOR INC.Inventors: Michele Heffernan, James Dorsey, Qun Fang, Robert Foglesong, Seth Hopkins, Michael Jones, Steven Jones, Cyprian Ogbu, Joe Perales, Mustapha Soukri, Kerry Spear, Mark Varney
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Publication number: 20080004327Abstract: This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O?X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.Type: ApplicationFiled: July 2, 2007Publication date: January 3, 2008Applicant: SEPRACOR INC.Inventors: Michele Heffernan, Robert Foglesong, Seth Hopkins, Mustapha Soukri, Steven Jones, Kerry Spear, Mark Varney
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Publication number: 20070203111Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.Type: ApplicationFiled: January 5, 2007Publication date: August 30, 2007Applicant: SEPRACOR INC.Inventors: Liming Shao, Fengjiang Wang, Scott Malcolm, Michael Hewitt, Larry Bush, Jianguo Ma, Mark Varney, Una Campbell, Sharon Engel, Larry Hardy, Patrick Koch, John Campbell
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Publication number: 20070197588Abstract: The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.Type: ApplicationFiled: December 21, 2006Publication date: August 23, 2007Applicant: SEPRACOR INC.Inventors: Liming Shao, Fengjiang Wang, Scott Malcolm, Michael Hewitt, Larry Bush, Mark Varney, Una Campbell, Sharon Engel, Larry Hardy, Patrick Koch, Jianguo Ma
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Patent number: 7213755Abstract: An add value terminal provides an automatic fare collection environment with a compact, easy to use, and easy to install device that re-values and issues transit fare smart cards exclusively utilizing credit and debit functions. The add value terminal alleviates long lines often associated with automatic vending machines that allow bill and coin transactions. The add value terminal also can be configured to sell tickets in out-of-station environments including malls, grocery stores, post offices, and airports.Type: GrantFiled: July 21, 2003Date of Patent: May 8, 2007Assignee: Cubic CorporationInventors: Matthew J. Newsome, Graham H. Hilton, Paula M. Miller, Jesse Shackleford, Chad S. Sanfilippo, Mark Varney, Kevin Bryant, Gavin Ford
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Publication number: 20050247574Abstract: A method for the electrochemical detection of carbon dioxide, which comprises causing at least a portion of the carbon dioxide to pass through a permeable membrane and dissolve in an aqueous electrolyte containing a metal ion and an organic ligand to form in situ in the electrolyte an equilibrium between the dissolved carbon dioxide species, the metal ion and the ligand concentrations and measuring the varying metal ion concentration and hence calculating the corresponding carbon dioxide concentration by means of measuring a current passing between electrodes present in the electrolyte. Also a gas detection apparatus comprising a housing, a gas permeable membrane, an aqueous electrolyte inside the housing with electrodes. The concentration of the gas is determined amperometrically.Type: ApplicationFiled: December 9, 2004Publication date: November 10, 2005Inventor: Mark Varney
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Patent number: 6956049Abstract: In accordance with the present invention, there are provided methods of modulating the activity of excitatory amino acid receptors using a specifically defined class of heterocyclic compounds. In one embodiment, there are provided methods of modulating metabotropic glutamate receptors. The present invention also discloses methods of treating disease using heterocyclic compounds.Type: GrantFiled: August 31, 1999Date of Patent: October 18, 2005Assignee: Merck & Co., Inc.Inventors: Nicholas D. P. Cosford, Ian A. McDonald, Stephen D. Hess, Mark A. Varney