Patents by Inventor Mark W. Duncan

Mark W. Duncan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MALDI-TOF MS Method And Apparatus For Assaying An Analyte In A Bodily Fluid From A Subject
    Publication number: 20160293394
    Abstract: A method for assaying an analyte in a bodily fluid from a subject includes collecting a sample of the bodily fluid comprising an analyte of interest from a subject. A sample with the bodily fluid comprising the analyte of interest suitable for analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) is then prepared. Mass spectrometry is then performed to determine mass-to-charge ratios and ion abundances of the bodily fluid or its components. The mass-to-charge ratio values and the ion abundance of each of these ratios are then analyzed using calibration standards to interpret a resulting mass spectrum and to provide quantitative information.
    Type: Application
    Filed: March 24, 2016
    Publication date: October 6, 2016
    Applicant: Virgin Instruments Corporation
    Inventors: Mark W. Duncan, Marvin L. Vestal, Stephen Hattan, Kenneth Parker
  • Biomarkers for follicular thyroid carcinoma and methods of use
    Patent number: 8455208
    Abstract: The present invention provides protein biomarkers for determining whether a thyroid nodule is malignant or benign and methods for using the same.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: June 4, 2013
    Assignee: The Regents of the University of Colorado
    Inventors: Stephen W. Hunsucker, Bryan R. Haugen, Mark W. Duncan, Romana Teodora Maier
  • Biomarkers for Follicular Thyroid Carcinoma and Methods of Use
    Publication number: 20120142030
    Abstract: The present invention provides protein biomarkers for determining whether a thyroid nodule is malignant or benign and methods for using the same.
    Type: Application
    Filed: April 14, 2008
    Publication date: June 7, 2012
    Applicant: The Regents of the University of Colorado, Body Co rporate
    Inventors: Stephen W. Hunsucker, Bryan R. Haugen, Mark W. Duncan, Romana Teodora Maier
  • Biomarkers for Diagnosis of Breast Cancer
    Publication number: 20110207156
    Abstract: The present invention provides methods and kits for determining breast cancer. The invention includes the identification and use of biomarkers that are present in different amount or differentially expressed in breast cancer versus normal controls.
    Type: Application
    Filed: October 29, 2009
    Publication date: August 25, 2011
    Applicant: The Regents of the University of Colorado
    Inventors: Mark W. Duncan, Lindsay Weitzel, Anthony Elias, Timothy Byers
  • Biomarkers for Babesia
    Publication number: 20090215086
    Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying babesia status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with babesia or not infected with babesia. The biomarkers can be detected by SELDI mass spectrometry.
    Type: Application
    Filed: December 12, 2006
    Publication date: August 27, 2009
    Inventors: Momar Ndao, Brian Ward, Peter Krause, Mark W. Duncan, Mike Edwards, Terence William Spithill
  • Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
    Publication number: 20040119010
    Abstract: The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.
    Type: Application
    Filed: October 30, 2003
    Publication date: June 24, 2004
    Applicant: The Regents of the University of Colorado
    Inventors: M. Benjamin Perryman, Steve M. Helmke, Mark W. Duncan