Patents by Inventor Mark W. Feinberg

Mark W. Feinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • An lncRNA integrates a DNA-PK-mediated DNA damage response and vascular senescence
    Publication number: 20220010310
    Abstract: Methods and compositions for use in treating subjects suffering from a disease associated with a malfunction in DNA repair response using compositions that comprise or encode SNHG12 long non-coding RNA.
    Type: Application
    Filed: November 12, 2019
    Publication date: January 13, 2022
    Inventors: Mark W. Feinberg, Stefan Haemmig
  • Enhancing dermal wound healing by downregulating microRNA-26a
    Patent number: 10260067
    Abstract: Methods for enhancing wound healing, e.g., in diabetic subjects, by administering an antagonist of miR-26a, e.g., an inhibitory nucleic acid that targets miR-26a.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: April 16, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Mark W. Feinberg
  • ENHANCING DERMAL WOUND HEALING BY DOWNREGULATING MICRORNA-26A
    Publication number: 20170298353
    Abstract: Methods for enhancing wound healing, e.g., in diabetic subjects, by administering an antagonist of miR-26a, e.g., an inhibitory nucleic acid that targets miR-26a.
    Type: Application
    Filed: October 1, 2015
    Publication date: October 19, 2017
    Applicant: The Brigham and Womens Hospital, Inc.
    Inventor: Mark W. Feinberg
  • Detection of organ rejection
    Patent number: 9790552
    Abstract: The present invention features methods and compositions for the non-invasive detection of organ rejection using a microRNA score.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: October 17, 2017
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventor: Mark W. Feinberg
  • Methods of treating vascular inflammatory disorders
    Patent number: 9534219
    Abstract: Provided are methods of treating or delaying the onset of a vascular inflammatory disease (e.g., acute lung injury) in a subject including administering to the subject a therapeutically effective amount of a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1). Also provided are methods of decreasing nuclear factor-?? (NF-??) signaling in an endothelial cell including administering to the subject a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1).
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: January 3, 2017
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Mark W. Feinberg, Xinghui Sun
  • Kruppel-like factor 10 (KLF10) as a biomarker of endothelial progenitor cell dysfunction
    Patent number: 9500658
    Abstract: The use of Kruppel-like Factor (KLF10) as a diagnostic and prognostic tool for peripheral artery disease and other disease conditions associated with reduced angiogenesis or endothelial progenitor cell dysfunction such as diabetes and stent thrombosis.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 22, 2016
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Mark W. Feinberg, Akm Khyrul Wara
  • Methods of using microRNA-26a to promote angiogenesis
    Patent number: 9322015
    Abstract: Methods for promoting angiogenesis, and for diagnosing the presence or risk of developing disorders associated with impaired angiogenesis or blood flow to a tissue in the body, using microRNA-26a (miR-26a).
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: April 26, 2016
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Mark W. Feinberg, Basak Icli
  • DETECTION OF ORGAN REJECTION
    Publication number: 20160010156
    Abstract: The present invention features methods and compositions for the non-invasive detection of organ rejection using a microRNA score.
    Type: Application
    Filed: July 1, 2015
    Publication date: January 14, 2016
    Inventor: Mark W. Feinberg
  • METHODS OF TREATING VASCULAR INFLAMMATORY DISORDERS
    Publication number: 20150152418
    Abstract: Provided are methods of treating or delaying the onset of a vascular inflammatory disease (e.g., acute lung injury) in a subject including administering to the subject a therapeutically effective amount of a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1). Also provided are methods of decreasing nuclear factor-?? (NF-??) signaling in an endothelial cell including administering to the subject a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1).
    Type: Application
    Filed: December 5, 2014
    Publication date: June 4, 2015
    Inventors: Mark W. Feinberg, Xinghui Sun
  • Methods of treating vascular inflammatory disorders
    Patent number: 8906875
    Abstract: Provided are methods of treating or delaying the onset of a vascular inflammatory disease (e.g., acute lung injury) in a subject including administering to the subject a therapeutically effective amount of a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1). Also provided are methods of decreasing nuclear factor-R? (NF-R?) signaling in an endothelial cell including administering to the subject a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1).
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: December 9, 2014
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Mark W. Feinberg, Xinghui Sun
  • DIAGNOSING, MONITORING AND TREATING INFLAMMATION
    Publication number: 20140194340
    Abstract: The present invention provides methods and compositions for treating chronic inflammatory disease in a subject and associated pharmaceutical compositions, medical devices and systems.
    Type: Application
    Filed: December 17, 2013
    Publication date: July 10, 2014
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventor: Mark W. Feinberg
  • Kruppel-like Factor 10 (KLF10) as a Biomarker of Endothelial Progenitor Cell Dysfunction
    Publication number: 20140162947
    Abstract: The use of Kruppel-like Factor (KLF10) as a diagnostic and prognostic tool for peripheral artery disease and other disease conditions associated with reduced angiogenesis or endothelial progenitor cell dysfunction such as diabetes and stent thrombosis.
    Type: Application
    Filed: March 9, 2012
    Publication date: June 12, 2014
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Mark W. Feinberg, Akm Khyrul Wara
  • Methods of Using microRNA-26a to Promote Angiogenesis
    Publication number: 20140121262
    Abstract: Methods for promoting angiogenesis, and for diagnosing the presence or risk of developing disorders associated with impaired angiogenesis or blood flow to a tissue in the body, using microRNA-26a (miR-26a).
    Type: Application
    Filed: March 9, 2012
    Publication date: May 1, 2014
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Mark W. Feinberg, Basak Icli
  • Diagnosing, monitoring and treating inflammation
    Patent number: 8691572
    Abstract: The present invention provides methods and compositions for treating chronic inflammatory disease in a subject and associated pharmaceutical compositions, medical devices and systems.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: April 8, 2014
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Mark W. Feinberg
  • METHODS OF TREATING VASCULAR INFLAMMATORY DISORDERS
    Publication number: 20130102546
    Abstract: Provided are methods of treating or delaying the onset of a vascular inflammatory disease (e.g., acute lung injury) in a subject including administering to the subject a therapeutically effective amount of a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1). Also provided are methods of decreasing nuclear factor-R? (NF-R?) signaling in an endothelial cell including administering to the subject a nucleic acid containing all or a part of the sequence of mature miR-181b (SEQ ID NO: 1).
    Type: Application
    Filed: March 9, 2011
    Publication date: April 25, 2013
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Mark W. Feinberg, Xinghui Sun
  • DETECTION OF ORGAN REJECTION
    Publication number: 20100086928
    Abstract: The present invention features methods and compositions for the non-invasive detection of organ rejection using a microRNA score.
    Type: Application
    Filed: December 20, 2007
    Publication date: April 8, 2010
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventor: Mark W. Feinberg
  • DIAGNOSING, MONITORING AND TREATING INFLAMMATION
    Publication number: 20100016938
    Abstract: The present invention provides methods and compositions for treating chronic inflammatory disease in a subject and associated pharmaceutical compositions, medical devices and systems.
    Type: Application
    Filed: May 11, 2009
    Publication date: January 21, 2010
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL , INC.
    Inventor: Mark W. Feinberg