Patents by Inventor Mark W. Grinstaff

Mark W. Grinstaff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210380655
    Abstract: Provided herein is a method to produce relaxin or relaxin analogues or variants and their use in methods of treatment, e.g., in the treatment of a stiffened fibrotic joint.
    Type: Application
    Filed: June 1, 2021
    Publication date: December 9, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Mark W. GRINSTAFF, Jack KIRSCH, William BLESSING
  • Publication number: 20210361745
    Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.
    Type: Application
    Filed: May 21, 2021
    Publication date: November 25, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, BETHISRAEL DEACONESS MEDICAL CENTER
    Inventors: Mark W. GRINSTAFF, William BLESSING, Amanda WILLIAMSON, Jack KIRSCH, Katherine COOK, Ara NAZARIAN, Edward K. RODRIGUEZ
  • Publication number: 20210275718
    Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.
    Type: Application
    Filed: April 23, 2021
    Publication date: September 9, 2021
    Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
  • Publication number: 20210259585
    Abstract: Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: James GALAGAN, Mark W. GRINSTAFF, Uros KUZMANOVIC, Mingfu CHEN, Margarita Alexandrovna TARARINA, Karen Nazaretian ALLEN
  • Patent number: 11027043
    Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: June 8, 2021
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
  • Publication number: 20210121263
    Abstract: The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.
    Type: Application
    Filed: December 14, 2020
    Publication date: April 29, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION
    Inventors: Mark W. GRINSTAFF, Boris Nicolas BLOCH, Jonah KAPLAN
  • Patent number: 10953107
    Abstract: Described herein are methods and compositions related to compositions comprising combinations of V/K-type and V/E-type docking peptides and uses thereof, e.g., to deliver therapeutic agents to treat certain conditions such as cancer, infection, or trauma.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 23, 2021
    Assignee: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Christopher Gromisch, Victoria Herrera, Nelson Ruiz-Opazo
  • Patent number: 10758403
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: September 1, 2020
    Assignee: HydroGlyde Coatings LLC
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Patent number: 10688216
    Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: June 23, 2020
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
  • Patent number: 10687976
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: June 23, 2020
    Assignee: HydroGlyde Coatings LLC
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Publication number: 20200170830
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Application
    Filed: February 5, 2020
    Publication date: June 4, 2020
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Patent number: 10646614
    Abstract: The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: May 12, 2020
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Mark W. Grinstaff, Cynthia Ghobril, Michel Christophe Wathier, Marlena Dagmara Konieczynska
  • Patent number: 10617794
    Abstract: Provided herein are methods comprising the use of a macroinitiator and application protocols to apply a hydrophilic coating to latex, or natural rubber, and compositions resulting from such methods. This coating results in e.g., an increased sense of lubrication when in contact with water or an aqueous solution.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: April 14, 2020
    Assignees: Trustees of Boston University, Boston Medical Center Corporation
    Inventors: Mark W. Grinstaff, Stacy L. Chin, Ruiqing Xiao, Benjamin Goldman Cooper, Karen Buch, Ducksoo Kim
  • Patent number: 10583034
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: March 10, 2020
    Assignee: HydroGlyde Coatings LLC
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Publication number: 20200056038
    Abstract: The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for biodegradable consumer plastics, adhesives, e.g., bioadhesives, pressure sensitive adhesives and thermos-responsive adhesives.
    Type: Application
    Filed: August 19, 2019
    Publication date: February 20, 2020
    Applicant: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Anjeza Beharaj
  • Publication number: 20200038233
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Application
    Filed: September 27, 2019
    Publication date: February 6, 2020
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Publication number: 20200008971
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 9, 2020
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Publication number: 20190381186
    Abstract: Described herein are methods and compositions related to the targeting of, e.g., therapeutic agents and uses thereof.
    Type: Application
    Filed: June 14, 2019
    Publication date: December 19, 2019
    Applicant: Trustees of Boston University
    Inventors: Mark W. GRINSTAFF, Christopher GROMISCH, Victoria HERRERA, Nelson RUIZ-OPAZO
  • Patent number: 10449084
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: October 22, 2019
    Assignee: HydroGlyde Coatings LLC
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Patent number: 10400064
    Abstract: The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for drug delivery, biodegradable consumer plastics, or solvents for Li-based batteries or supercapacitors.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: September 3, 2019
    Assignee: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Heng Zhang, Iriny Ekladious, Marlena D. Konieczynska