Patents by Inventor Mark W. Grinstaff

Mark W. Grinstaff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240197860
    Abstract: The technology described herein is directed to compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA (saRNA). Also described herein are compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA that is substituted with chemically modified nucleotides.
    Type: Application
    Filed: November 17, 2023
    Publication date: June 20, 2024
    Applicant: Trustees of Boston University
    Inventors: Joshua Edward MCGEE, Jack Rainier KIRSCH, Eric BRESSLER, Mark W. GRINSTAFF, Wilson WONG, Lidya Yidnekachew Sertse, Kexin Li
  • Patent number: 11883246
    Abstract: The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: January 30, 2024
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION
    Inventors: Mark W. Grinstaff, Boris Nicolas Bloch, Jonah Kaplan
  • Publication number: 20240024505
    Abstract: The disclosure relates generally to methods and compositions for generation or enhancement of partial or complete cellular signaling pathways
    Type: Application
    Filed: July 12, 2023
    Publication date: January 25, 2024
    Applicant: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Jack R. Kirsch, Amanda K. Williamson, Brett Tingley
  • Publication number: 20230381142
    Abstract: Provided herein are antileishmanial compounds, compositions comprising the antileishmanial compounds, and use thereof.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 30, 2023
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Scott E. SCHAUS, Lauren E. BROWN, Mark W. GRINSTAFF, Danielle M. FITZGERALD, Diana L. DIAZ, John A. KAVOURIS, Jair LAGE DE SIQUEIRA-NETO, James MCKERROW, Camila INDIANI DE OLIVEIRA
  • Patent number: 11826485
    Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: November 28, 2023
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
  • Patent number: 11819578
    Abstract: The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: November 21, 2023
    Assignees: Trustees of Boston University, The General Hospital Corporation
    Inventors: Eric M. Bressler, Sarah Adams, Yolonda Colson, Mark W. Grinstaff, Wilson Wai Chun Wong
  • Publication number: 20230190657
    Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 22, 2023
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Mark W. Grinstaff, William Blessing, Amanda Williamson, Jack Kirsch, Katherine Cook, Ara Nazarian, Edward K. Rodriguez
  • Publication number: 20230114205
    Abstract: The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.
    Type: Application
    Filed: October 7, 2022
    Publication date: April 13, 2023
    Applicants: Trustees of Boston University, The General Hospital Corporation
    Inventors: Eric M. Bressler, Sarah Adams, Yolonda Colson, Mark W. Grinstaff, Wilson Wai Chun Wong
  • Patent number: 11439685
    Abstract: The present invention provides formulations for the treatment of fibrotic diseases and disorders. In some embodiments, the formulation comprises a microparticle that includes an antifibrotic.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: September 13, 2022
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Mark W. Grinstaff, William Blessing, Amanda Williamson, Jack Kirsch, Katherine Cook, Ara Nazarian, Edward K. Rodriguez
  • Patent number: 11401374
    Abstract: The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for biodegradable consumer plastics, adhesives, e.g., bioadhesives, pressure sensitive adhesives and thermos-responsive adhesives.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: August 2, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Mark W. Grinstaff, Anjeza Beharaj
  • Patent number: 11331020
    Abstract: Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: May 17, 2022
    Assignee: Trustees of Boston University
    Inventors: James Galagan, Mark W. Grinstaff, Uros Kuzmanovic, Mingfu Chen, Margarita Alexandrovna Tararina, Karen Nazaretian Allen
  • Publication number: 20210380655
    Abstract: Provided herein is a method to produce relaxin or relaxin analogues or variants and their use in methods of treatment, e.g., in the treatment of a stiffened fibrotic joint.
    Type: Application
    Filed: June 1, 2021
    Publication date: December 9, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Mark W. GRINSTAFF, Jack KIRSCH, William BLESSING
  • Publication number: 20210361745
    Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.
    Type: Application
    Filed: May 21, 2021
    Publication date: November 25, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, BETHISRAEL DEACONESS MEDICAL CENTER
    Inventors: Mark W. GRINSTAFF, William BLESSING, Amanda WILLIAMSON, Jack KIRSCH, Katherine COOK, Ara NAZARIAN, Edward K. RODRIGUEZ
  • Publication number: 20210275718
    Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.
    Type: Application
    Filed: April 23, 2021
    Publication date: September 9, 2021
    Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
  • Publication number: 20210259585
    Abstract: Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: James GALAGAN, Mark W. GRINSTAFF, Uros KUZMANOVIC, Mingfu CHEN, Margarita Alexandrovna TARARINA, Karen Nazaretian ALLEN
  • Patent number: 11027043
    Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: June 8, 2021
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
  • Publication number: 20210121263
    Abstract: The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.
    Type: Application
    Filed: December 14, 2020
    Publication date: April 29, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION
    Inventors: Mark W. GRINSTAFF, Boris Nicolas BLOCH, Jonah KAPLAN
  • Patent number: 10953107
    Abstract: Described herein are methods and compositions related to compositions comprising combinations of V/K-type and V/E-type docking peptides and uses thereof, e.g., to deliver therapeutic agents to treat certain conditions such as cancer, infection, or trauma.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 23, 2021
    Assignee: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Christopher Gromisch, Victoria Herrera, Nelson Ruiz-Opazo
  • Patent number: 10758403
    Abstract: The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: September 1, 2020
    Assignee: HydroGlyde Coatings LLC
    Inventors: Stacy Lee Chin, Benjamin Goldman Cooper, Ruiqing Xiao, Mark W. Grinstaff
  • Patent number: 10688216
    Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: June 23, 2020
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff