Patents by Inventor Mark W. Knuth

Mark W. Knuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID BINDING PROTEIN FORMULATIONS AND USES THEREOF
    Publication number: 20240209355
    Abstract: Provided herein are methods and compositions relating to stable aqueous formulations, cell mediums, and ex vivo editing methods for gene editing by site-directed modifying polypeptides.
    Type: Application
    Filed: June 22, 2023
    Publication date: June 27, 2024
    Inventors: Aaron Cantor, Benjamin G. Gowen, Mark W. Knuth
  • Crystallization of histone deacetylase 2
    Patent number: 7507552
    Abstract: Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: March 24, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Mark T. Hilgers, Mark W. Knuth, Marc E. Navre, Bi Ching Sang, Robert J. Skene, Leslie W. Tari, Keith P. Wilson, Darbi Witmer, Hua Zou
  • Crystallization of aurora/LPL1P-related kinase
    Patent number: 7444273
    Abstract: Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: October 28, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Mark W. Knuth, Duncan E. McRee, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson, Robert A. Wijnands
  • Crystallization of MAPK/ERK Kinase 2
    Patent number: 7368269
    Abstract: Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: May 6, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Douglas R. Dougan, Mark W. Knuth, Michelle L. Kraus, Kheng Lim, Clifford D. Mol, Gyorgy Snell, Hua Zou
  • Crystallization of dipeptidyl peptidase IV (DPPIV)
    Patent number: 7344852
    Abstract: Provided are crystals relating to DPPIV and its various uses.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: March 18, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Kathleen Aertgeerts, Ciaran N. Cronin, David J. Hosfield, Mark W. Knuth, Duncan E. McRee, Sridhar Prasad, Bi Ching Sang, Robert J. Skene, Robert A. Wijnands, Sheng Ye
  • Crystallization of cathepsin S
    Patent number: 7319016
    Abstract: Provided are crystals relating to Cathepsin S and its various uses.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 15, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ellen Chien, Douglas R. Dougan, Mark W. Knuth, Duncan E. McRee, Bi Ching Sang, Robert J. Skene, Ronald V. Swanson, Leslie W. Tari, Robert A. Wijnands
  • Crystallization of AKT3
    Patent number: 7303892
    Abstract: Provided are crystals relating to AKT3 and its various uses.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: December 4, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Eric Adam, Oleg Brodsky, Mark W. Knuth, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson, Robert A. Wijnands
  • Purification of somatotropin from transformed microorganisms
    Patent number: 6916914
    Abstract: This invention discloses a commercially advantageous process for extraction and purification of protein from microorganisms. The initial steps of the process are useful for purifying many insoluble proteins while later steps are designed to renature denatured somatotropins produced by transformed microorganisms. The process is especially useful for purifying recombinantly-produced bovine somatotropin.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: July 12, 2005
    Assignee: Pharmacia & Upjohn Co.
    Inventors: Timothy W. Evans, Mark W. Knuth
  • High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
    Patent number: 6764689
    Abstract: A process for producing and purifying peptides and for producing peptide/protein antigens for antibody production is described. The process utilizes fusion proteins and specifically fusion proteins in which the fusion protein carrier segment includes an amino acid sequence at least about 65 amino acids long and in which the amino acid sequence does not contain negative or positive charged side chains of amino acids.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: July 20, 2004
    Assignee: Promega Corporation
    Inventors: Mark W. Knuth, Mary Haak-Frendscho, John W. Shultz, Scott A. Lesley, Catherine E. Villars
  • Purification of somatotropin from transformed microorganisms
    Patent number: 6586575
    Abstract: This invention discloses a commercially advantageous process for extraction and purification of protein from microorganisms. The initial steps of the process are useful for purifying many insoluble proteins while later steps are designed to renature denatured somatotropins produced by transformed microorganisms. The process is especially useful for purifying recombinantly-produced bovine somatotropin.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: July 1, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Timothy W. Evans, Mark W. Knuth
  • High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
    Patent number: 6069230
    Abstract: A process for pro and purifying peptides and for producing peptide/protein antigens for antibody production is described. The process utilizes fusion proteins and specifically fusion proteins in which the fusion protein carrier segment includes an amino acid sequence at least about 65 amino acids long and in which the amino acid sequence does not contain negative or positive charged side chains of amino acids.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: May 30, 2000
    Assignee: Promega Corporation
    Inventors: Mark W. Knuth, Mary Haak-Frendscho, John W. Shultz, Scott A. Lesley, Catherine E. Villars
  • Isolated agarase enzyme from flavobacterium SP. strain NR19, cloned genes therefor, and expression thereof in transformed host cells
    Patent number: 6001636
    Abstract: Novel purified agarase enzymes from Flavobacterium sp. strain NR19 and cloned genes encoding the agarase enzymes are disclosed. Transformed host cells which express the novel agarase enzymes in isolatable quantities are also described. Also disclosed are antibodies specifically reactive with the novel agarases.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: December 14, 1999
    Assignee: Promega Corporation
    Inventors: Mark W. Knuth, Kimberly K. Knoche, Susanne Selman, James R. Hartnett
  • High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
    Patent number: 5989554
    Abstract: A process for producing and purifying peptides and for producing peptide/protein antigens for antibody production is described. The process utilizes fusion proteins and specifically fusion proteins in which the fusion protein carrier segment includes an amino acid sequence at least about 65 amino acids long and in which the amino acid sequence does not contain negative or positive charged side chains of amino acids.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: November 23, 1999
    Assignee: Promega Corporation
    Inventors: Mark W. Knuth, Mary Haak-Frendscho, John W. Shultz, Scott A. Lesley, Catherine E. Villars
  • Isolated agarase enzyme from flavobacterium sp. strain NR19, cloned genes therefor, and expression thereof in transformed host cells
    Patent number: 5869310
    Abstract: Novel purified agarase enzymes from Flavobacterium sp. strain NR19 and cloned genes encoding the agarase enzymes are disclosed. Transformed host cells which express the novel agarase enzymes in isolatable quantities are also described. Also disclosed are antibodies specifically reactive with the novel agarases.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: February 9, 1999
    Assignee: Promega Corporation
    Inventors: Mark W. Knuth, Kimberly K. Knoche, Susanne Selman, James R. Hartnett
  • Use of agarase enzyme to isolate nucleic acids
    Patent number: 5814487
    Abstract: A process for isolating nucleic acids from agarose, and particularly regular agarose, is described wherein the agarose is augmented with a chaotropic substance and hydrolyzed by a novel purified agarase enzyme from Flavobacterium sp. strain NR19.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: September 29, 1998
    Assignee: Promega Corporation
    Inventors: Mark W. Knuth, Susanne Selman