Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

Abstract: Methods for classification of biological data including the use of mathematically based classification models are disclosed. In preferred embodiments, gene expression data derived from biological studies is used to classify events. The methods use a version of a linear discriminate model for deriving markers according to a technique whereby the model is limited to scoring the predictive ability of genes without making assumptions about inter-gene relationships, relative magnitudes or redundant information. In an associated method for building a fully informative database of biological information, biological studies are performed on a continual basis and linear discriminate models are used to provide rapid and efficient updates to gene markers.

Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

Abstract: An improved disk harrow C-spring with a tapered cross section which reduces the compressive stresses in the inside radius and improves vertical and side-to-side flexibility. The curved portion of the C-spring has a constant cross section at the top and around three-fourths of the bend. At a location on the bend 45 degrees down from the horizontal, the thickness tapers to a location forward of the bearing hanger. The cross section is constant from the end of the taper to the end of the spring. The tapered cross section allows a thicker section to be used on the most highly stressed areas in the upper quadrant of the curved portion of the C-spring. The lower quadrant taper results in uniform stress distribution along the entire C-spring with the maximum compressive stress on the inside radius reduced substantially over a conventional C-spring. In addition, the tapered design provides an increase in both vertical and side-to-side flexibility for improved operation in rocky soil.

Abstract: A cotton harvester with an offset head having four row units positioned for harvesting cotton planted in uniformly spaced narrow rows. The frame of the harvester is supported near its forward end by a pair of drive wheels adapted to run between two pairs of rows of cotton. The head is offset so that three rows of cotton are accommodated between the wheels and one row of cotton is accommodated outside one of the wheels. The machine drive and guide wheels can therefore be positioned between the rows for ease in steering and driving. A cotton basket on the harvester can be dumped toward the side which is unobstructed by a harvesting unit so the receiving implement can be positioned closer to the harvester and so the head which is offset in the opposite direction can act as a counterweight to balance the harvester as the basket is extended transversely for dumping.