Abstract: A system includes a tubing set and a drive assembly. The tubing set includes inlet tubing couplable to a source of fluid, a valve coupled to the inlet tubing, a syringe coupled to the inlet tubing via the valve, and outlet tubing coupled to the valve. The valve is configured to allow fluid to be drawn from the source of fluid via the inlet tubing into a syringe body of the syringe and to be expelled from the syringe body and through the outlet tubing, and to prevent fluid from being drawn from the outlet tubing into the syringe body and to prevent fluid expelled from the syringe body from flowing through the inlet tubing. The drive assembly is configured to reversibly receive the tubing set such that a drive mechanism is engaged with a plunger of the syringe to reciprocally translate the plunger relative to the syringe body.

Abstract: Systems, devices, and methods for providing alternative content in audio-video streams are disclosed. A manifest data structure including data reflective of a plurality of content segments is generated. At least one alternative content indicator, each indicating one of said plurality of content segments as being an alternative content segment is obtained. The manifest data structure is modified to remove data reflective of those of said plurality of content segments that are not indicated by said one of said alternative content indicators as being an alternative content segment. Upon receiving a request from a client device to view alternative content, the modified manifest data structure is sent to the client device.

Abstract: This disclosure relates generally to inhibitors of MHC-I downmodulation, and methods of treating or preventing an HIV infection by administering the inhibitors to a patient in need of treatment thereof.

Abstract: Systems, devices, and methods for providing alternative content in audio-video streams are disclosed. A manifest data structure including data reflective of a plurality of content segments is generated. At least one alternative content indicator, each indicating one of said plurality of content segments as being an alternative content segment is obtained. The manifest data structure is modified to remove data reflective of those of said plurality of content segments that are not indicated by said one of said alternative content indicators as being an alternative content segment. Upon receiving a request from a client device to view alternative content, the modified manifest data structure is sent to the client device.