Abstract: The present invention provides improved cell culture systems that allow optimum production of recombinant proteins. Among other things, the present invention provides methods of cell culture including a step of cultivating cells adapted to growth factor-free medium in a cell culture system that provides at least one growth factor.

Abstract: Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

Abstract: In one aspect of a multiple-access OFDM-CDMA system, the data spreading is performed in the frequency domain by spreading each data stream with a respective spreading code selected from a set of available spreading codes. To support multiple access, system resources may be allocated and de-allocated to users (e.g., spreading codes may be assigned to users as needed, and transmit power may be allocated to users). Variable rate data for each user may be supported via a combination of spreading adjustment and transmit power scaling. Interference control techniques are also provided to improve system performance via power control of the downlink and/or uplink transmissions to achieve the desired level of performance while minimizing interference. A pilot may be transmitted by each transmitter unit to assist the receiver units perform acquisition, timing synchronization, carrier recovery, handoff, channel estimation, coherent data demodulation, and so on.

Abstract: An apparatus and method for transmit power savings comprising determining a rate of a previous frame; determining if a current frame is an ALWAYS-ON frame, wherein the current frame temporally succeeds the previous frame; and either ignoring every other reverse link power control (RLPC) bits received on a forward power control subchannel (F-PCSCH) or applying every RLPC bits received on the F-PCSCH. In one aspect, the apparatus and method for transmit power savings comprising using a rate determination algorithm (RDA) to determine a rate of a previous frame; detecting a pilot gating pattern at the end of the previous frame; comparing the rate of the previous frame to a threshold; determining if a current frame is an ALWAYS-ON frame; and declaring the current frame to be a 0 bps frame and puncturing the F-PCSCH to a predetermined frequency.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: The invention covers a cartridge for use in a hemodialysis machine, the cartridge comprising a dialysate flow path including a dialyzer, the dialysate flow path for delivering a flow of dialysate through the dialyzer; a mixing pump defining a chamber having volume variable between a maximum volume and a minimum volume for receiving a predetermined volume of a first dialysate solution base, second dialysate solution base, and a volume of water; a first dialysate solution base supply conduit having a first positive displacement pump having a first inlet valve and a first outlet valve associated therewith; a second dialysate solution base supply conduit having a second positive displacement pump having a second inlet valve and a second outlet valve associated therewith; a first and second fluid conduit associated joining respective first and second positive displacement pumps with the mixing pump; and a third fluid conduit for connecting the mixing pump outlet to a dialyzer filter inlet.

Abstract: A cartridge for use in a hemodialysis machine, the cartridge comprising a dialysate flow path including a dialyser, the dialysate flow path for delivering a flow of dialysate to the dialyser; a first mixing pump comprising a chamber having a fixed volume between a concave recess and a flexible membrane, said chamber for receiving a predetermined volume of a first dialysate solution base, and a volume of water; a flow balancing pump comprising: a chamber having a fixed volume between a concave recess and a flexible membrane, and inlet through which it receives dialysate; a fluid flow path connecting the first mixing pump to the flow balancing pump; the cartridge further comprising a first check valve having an inlet in fluid communication with said fluid flow path, said check valve configured to open if the pressure in the fluid flow path exceeds a predetermined pressure to allow excess fluid in the fluid flow path to flow through the first check valve to a drain, and to close when the pressure in the fluid fl

Abstract: A pump for a dialysis machine, the pump having a pump chamber and a deformable membrane actuable to pump a fluid from the pump chamber, the pump chamber being substantially conical such that the membrane is actuated to extend into the conical chamber in order to pump the fluid from the chamber.

Abstract: A multi-part kit system comprising a solid part A which comprises at least one acetyl donor, a liquid part B in the form of an aqueous composition which comprises 3 to 35 wt. % of hydrogen peroxide and one or more parts C, wherein the solid part A and/or the part(s) C comprise at least one surfactant selected from the group consisting of anionic surfactants, amphoteric surfactants and nonionic surfactants, wherein the composition of the parts of the multi-part kit system is such, that directly after being mixed with each other and water in a specified ratio the pH of the mixture is in the range of 5.5 to 8.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Techniques for processing a data transmission at the transmitter and receiver. In an aspect, a time-domain implementation is provided which uses frequency-domain singular value decomposition and “water-pouring” results to derive time-domain pulse-shaping and beam-steering solutions at the transmitter and receiver. The singular value decomposition is performed at the transmitter to determine eigen-modes (i.e., spatial subchannels) of the MIMO channel and to derive a first set of steering vectors used to “precondition” modulation symbols. The singular value decomposition is also performed at the receiver to derive a second set of steering vectors used to precondition the received signals such that orthogonal symbol streams are recovered at the receiver, which can simplify the receiver processing. Water-pouring analysis is used to more optimally allocate the total available transmit power to the eigen-modes, which then determines the data rate and the coding and modulation scheme to be used for each eigen-mode.

Abstract: Transmitter and receiver units for use in an OFDM communications system and configurable to support multiple types of services. The transmitter unit includes one or more encoders, a symbol mapping element, and a modulator. Each encoder receives and codes a respective channel data stream to generate a corresponding coded data stream. The symbol mapping element receives and maps data from the coded data streams to generate modulation symbol vectors, with each modulation symbol vector including a set of data values used to modulate a set of tones to generate an OFDM symbol. The modulator modulates the modulation symbol vectors to provide a modulated signal suitable for transmission. The data from each coded data stream is mapped to a respective set of one or more “circuits”. Each circuit can be defined to include a number of tones from a number of OFDM symbols, a number of tones from a single OFDM symbol, all tones from one or more OFDM symbols, or some other combination of tones.

Abstract: The present invention discloses ?-diketones, ?-diketones or ?-hydroxyketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract: Techniques to process data for transmission in a time division duplexed (TDD) communication system. In one aspect, the frequency response of a forward link is estimated at a base station based on reverse link transmissions (e.g., pilots) from a terminal. Prior to a data transmission on the forward link, the base station determines a reverse transfer function based on the pilots transmitted by the terminal, “calibrates” the reverse transfer function with a calibration function to derive an estimate of a forward transfer function, and preconditions modulation symbols based on weights derived from the forward transfer function. In another aspect, the terminal estimates the “quality” of the forward link and provides this information to the base station. The base station then uses the information to properly code and modulate data prior to transmission such that the transmitted data can be received by the terminal at the desired level of performance.

Abstract: Improved methods for manufacturing silicon carbide rings using chemical vapor deposition. Cylindrical tubes are used as deposition substrates and the resulting material deposited on the inside surface of cylindrical tubes or on the outside surface of cylindrical mandrels, or both, is sliced or cut into the desired ring size and shape. The resulting rings have a crystal growth that is oriented substantially planar to the finished article. The invention also relates to nitrogen doped silicon carbide material, as well as to silicon carbide structures having axes of grain growth substantially parallel to the plane of the structure and to each other, and having rotational orientation that is substantially random with respect to the axes of grain growth of the grains.

Abstract: Techniques to schedule terminals for data transmission on the downlink and/or uplink in a MIMO-OFDM system based on the spatial and/or frequency “signatures” of the terminals. A scheduler forms one or more sets of terminals for possible (downlink or uplink) data transmission for each of a number of frequency bands. One or more sub-hypotheses may further be formed for each hypothesis, with each sub-hypothesis corresponding to (1) specific assignments of transmit antennas to the terminal(s) in the hypothesis (for the downlink) or (2) a specific order for processing the uplink data transmissions from the terminal(s) (for the uplink). The performance of each sub-hypothesis is then evaluated (e.g., based on one or more performance metrics). One sub-hypothesis is then selected for each frequency band based on the evaluated performance, and the one or more terminals in each selected sub-hypothesis are then scheduled for data transmission on the corresponding frequency band.

Abstract: In one aspect of a multiple-access OFDM-CDMA system, data spreading is performed in the frequency domain by spreading each data stream with a respective spreading code selected from a set of available spreading codes. To support multiple access, system resources may be allocated and de-allocated to users (e.g., spreading codes may be assigned to users as needed, and transmit power may be allocated to users). Variable rate data for each user may be supported via a combination of spreading adjustment and transmit power scaling. Interference control techniques are also provided to improve system performance via power control of the downlink and/or uplink transmissions to achieve the desired level of performance while minimizing interference. A pilot may be transmitted by each transmitter unit to assist the receiver units perform acquisition, timing synchronization, carrier recovery, handoff, channel estimation, coherent data demodulation, and so on.

Abstract: Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

Abstract: The improved jump ropes devices described herein generally include a source of rhythmic sound, a sensor for determining the motion of the jump rope, and a visual output (e.g., feedback) for indicating how well a user is moving or jumping in time to the rhythmic component of the sound. The device may also include a controller for receiving input from the source of rhythmic sound and the sensor, and controlling the visual output. Methods of using the devices are also described.