Abstract: A film composite with protection against tampering includes a base film, which is arranged as the lowermost layer in the film composite, and a cover layer, which is arranged as the uppermost layer in the film composite. The film composite further includes an intermediate film, which is arranged between the base film and the cover layer, and a laser-inscribable layer, which is arranged in the film composite between the base film and the intermediate film. Lines of weakening are provided in the film composite, which run within the base film and within the intermediate film.

Abstract: An imaging needle apparatus, associated system, and method of use are described. The apparatus includes various interchangeable modules, including a trocar assembly, a blunt cannula assembly, and an arthroscope assembly, such as a nano-arthroscope. For example, using the imaging needle apparatus, a doctor can treat a patient by inserting the trocar assembly into the patient's body, inserting the blunt cannula assembly into the body via the trocar assembly, removing the trocar assembly, and inserting the arthroscope assembly into the blunt cannula assembly. Further, the imaging needle apparatus, in some embodiments, includes a light engine that provides a light source for a camera cannula of the apparatus, such as a camera cannula that is part of the arthroscope assembly.

Abstract: Disclosed herein are intravaginal ring (IVR) devices comprising barriers that may be metal, polymeric or combinations of metal and polymeric. The IVRs are useful for contraception, treating and/or preventing sexually transmitted diseases, and treating and/or preventing bacterial infections. The IVR's are resistant to distortion due to absorption of vaginal fluids. This allows the IVRs to perform better over time as compared to other intravaginal rings made with copolymeric silicone.

Abstract: The present disclosure generally relates to compositions and techniques for vaginal insertion. In some embodiments, a composition such as a gel may be applied to the vagina of a subject that is relatively viscous, for example, with a viscosity at room temperature of at least 1.5 million cP. The composition may also contain an active ingredient, e.g., dinoprostone, diclofenac, and/or salts thereof. Compositions having such relatively high viscosities may be useful, for example, to prevent the composition from readily exiting the vagina or degrading too quickly. This may, for example, allow the composition to release the active ingredient over a relatively long period of time to the vagina. In some embodiments, such compositions may be prepared by removing air from the composition to increase its viscosity or cause the composition to form a gel, etc.

Abstract: A pharmaceutical composition for use in the treatment of bacterial vaginosis, wherein said composition comprises a poloxamer, a stabilization polymer, and an active ingredient for treating the bacterial vaginosis, preferably clindamycin, wherein said composition has a viscosity of at least 1.5 million mPa·s.

Abstract: Methods of treating cancer with a precision genome engineered NeoTCR Product are described herein.

Abstract: In one aspect, the present invention provides recombinant polynucleotides. In some embodiments, the recombinant polynucleotides comprise a cytomegalovirus (CMV) genome, or a portion thereof, and a nucleic acid sequence encoding an antigen, wherein the CMV genome or portion thereof comprises a mutation within a interleukin-10-like gene sequence. Methods for preventing and treating diseases such as infectious diseases and cancer are also provided herein.

Abstract: Described herein are methods and compositions for treating a beta-thalassemia.

Abstract: A film composite with protection against tampering includes a base film, which is arranged as the lowermost layer in the film composite, and a cover layer, which is arranged as the uppermost layer in the film composite. The film composite further includes an intermediate film, which is arranged between the base film and the cover layer, and a laser-inscribable layer, which is arranged in the film composite between the base film and the intermediate film. Lines of weakening are provided in the film composite, which run within the base film and within the intermediate film.

Abstract: An apparatus includes a slotted tube having a plurality of first slots and a plurality of second slots; an imager disposed in the slotted tube, the imager having a plurality of corners arranged in the plurality of first slots; and a plurality of light guides disposed in the plurality of second slots.

Abstract: A film structure with protection against manipulation includes a top film, a laser-inscribable layer which is arranged on the bottom side of the top film, and also a bottom film and a connecting layer for connecting the bottom film to the top film and the laser-inscribable layer. The connecting layer is arranged between the laser-inscribable layer and the bottom film. The film structure has an inscribed region and an uninscribed region. The top film is fused with the bottom film in the inscribed region of the film structure. As a result, it is virtually impossible to separate the top film with the inscribed layer from the bottom film without destruction in the event of a manipulation attempt.

Abstract: Techniques for distributed network connectivity monitoring of provider network edge location resources from cellular networks are described. A central service transmits test suites of commands to agents executed by test devices, which can execute the commands to test network characteristics between the test devices and target locations via one or multiple cellular communications networks. Results of the testing are sent back to the central service for processing, and the resultant metrics can be used for intelligent latency-based routing of clients, latency-based placement of resources, and/or performance monitoring of deployed resources.

Abstract: A method for secure anonymous payment processing of Services or Virtual Assets. Initially, a Buyer selects an offered Service or Virtual Asset from a Web Site or via a Mobile Application. The Buyer is then challenged to provide a Secondary Factor Authentication to verify the Buyer's identity via a software application such as Google Authenticator, or via a hardware solution such as Yubico or Symantec. Once the Buyer is authenticated, the system allows for the input of the public cryptocurrency addresses. Sellers are similarly authenticated and can add public cryptocurrency addresses, schedules and pricing structures to build offers for sale.

Abstract: Techniques for distributed network connectivity monitoring of provider network edge location resources from cellular networks are described. A central service transmits test suites of commands to agents executed by test devices, which can execute the commands to test network characteristics between the test devices and target locations via one or multiple cellular communications networks. Results of the testing are sent back to the central service for processing, and the resultant metrics can be used for intelligent latency-based routing of clients, latency-based placement of resources, and/or performance monitoring of deployed resources.

Abstract: Techniques for distributed network connectivity monitoring of provider network edge location resources from cellular networks are described. A central service transmits test suites of commands to agents executed by test devices, which can execute the commands to test network characteristics between the test devices and target locations via one or multiple cellular communications networks. Results of the testing are sent back to the central service for processing, and the resultant metrics can be used for intelligent latency-based routing of clients, latency-based placement of resources, and/or performance monitoring of deployed resources.

Abstract: An imaging apparatus includes a hub; a needle extending from the hub, a probe provided within the needle and configured to extend and retract, an imager disposed in the probe, and an interposer provided within the needle. The imager is configured to generate an imaging signal. The interposer includes a substrate and a conductive line patterned on the substrate. The interposer is configured to receive the image signal from the imager via the conductive line.

Abstract: An apparatus includes a slotted tube having a plurality of first slots and a plurality of second slots; an imager disposed in the slotted tube, the imager having a plurality of corners arranged in the plurality of first slots; and a plurality of light guides disposed in the plurality of second slots.

Abstract: An apparatus includes a trimmed imager including an imager chip and an encapsulation layer, the imager chip have a polygonal cross-section with a first number of corners, the encapsulation layer being disposed around the polygonal cross-section of the imager chip and having a second number of corners that is greater than the first number of corners; and a slotted tube having a plurality of first slots, the corners of the encapsulation layer being disposed in the plurality of first slots.

Abstract: Disclosed herein are intravaginal ring (IVR) devices comprising barriers that may be metal, polymeric or combinations of metal and polymeric. The IVRs are useful for contraception, treating and/or preventing sexually transmitted diseases, and treating and/or preventing bacterial infections. The IVR's are resistant to distortion due to absorption of vaginal fluids. This allows the IVRs to perform better over time as compared to other intravaginal rings made with copolymeric silicone.

Abstract: Methods of treating cancer with a precision genome engineered NeoTCR Product are described herein.