Abstract: A controller coupled to plural mobile devices through a mobile communications environment including multiple available networks at a location remote from the plural mobile devices. The plural mobile devices are simultaneously connected to plural networks and collecting network data for each simultaneously connected plural multiple networks. The controller includes a receiver receiving from each mobile device the collected network data, where each mobile device is connected to the receiver via an active one of the simultaneously connected plural multiple networks for transmitting the collected network data; a processor configured to evaluate the collected network data from each mobile device and, based upon respective rules established for each mobile device, to produce respective sets of operating parameters for the plural mobile devices; and a transmitter to transmit to each mobile device the respective sets of operating parameters.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: Provided is an optical modulator including a substrate, and a plurality of meta units provided on the substrate and spaced apart from each other, wherein at least one of the plurality of meta units includes a metal layer provided on the substrate, a dielectric layer provided an upper surface and side surfaces of the metal layer, and an antenna provided on an upper surface of the dielectric layer, the antenna including phase change material, wherein a refractive index of the phase change material changes based on a voltage applied to the metal layer to modulate incident light.

Abstract: Methods of selectively depositing a carbon-containing layer are described. Exemplary processing methods may include flowing a first precursor over a substrate comprising a metal surface and a non-metal surface to form a first portion of an initial carbon-containing film on the metal surface. The methods may include removing a first precursor effluent from the substrate. A second precursor may then be flowed over the substrate to react with the first portion of the initial carbon-containing layer. The methods may include removing a second precursor effluent from the substrate. The methods may include pre-treating the metal surface of the substrate to form a metal oxide surface on the metal surface.

Abstract: An eyewear system including an eyewear frame and an application module. The eyewear frame including a docking station, and an electronic connector including a first set of preconfigured application connection points. The application module adapted to be mounted to the docking station, and including an electronic device configured to perform a function, and a second set of preconfigured application connection points corresponding to at least some of the first set of preconfigured application connection points. The second set of preconfigured application connection points including at least two different sub-function connections used to support the function of the electronic device.

Abstract: A food recycler includes a case, a control system within the case, and a set of user interface components that are usable to at least cause the control system to initiate a food recycling cycle. The food recycler also includes a motor within the case and a bucket that has a volumetric capacity between 2.51 and 10 liters. A filter system configured to accommodate air filters is also included in the case of the food recycler. To remove water from waste food items, the food recycler includes a drying component.

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: To provide enhanced search capabilities in a process control system, a knowledge repository is generated that includes both contextual data and time series data. The contextual data organizes process plant-related data according to semantic relations between the process plant-related data and the process plant entities. When a user submits a process plant search query related to process plant entities within a process plant, search results are obtained by identifying a data set from the knowledge repository. The contextual data categorizes process parameters so that users can search for a particular process parameter category. Users can tag previous searches to execute them once again at a later time.

Abstract: This invention in one aspect relates to a mixed-kernel heterojunction transistor, comprising a monolayer film formed of an atomically thin material, and a network of carbon nanotubes (CNTs) vertically stacked over the monolayer film to define an overlap region of the CNT network with the monolayer film, and non-overlap regions of the monolayer film and the CNT network, wherein the overlap region is a mixed-kernel van der Waals heterojunction.

Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A method of aligning a plurality of targets is provided. The method includes generating a plurality of targets. A third phase includes the plurality of targets. The method further includes combining a first phase, a second phase, and the third phase in a volume. The first phase, the second phase, and the third phase are substantially immiscible, and the third phase is in fluid communication with the first phase and the second phase, and the first phase, the second phase, and the third phase are operable to be in a configuration of the third phase between the first phase and the second phase in the volume.

Abstract: Consolidated, porous core layers that are lightweight while retaining the mechanical properties of heavier core layers are described. The consolidated, porous core layer can include a porous web formed from reinforcing materials held in place by a thermoplastic material. The consolidated, porous core layer can also include a lofting agent or other additives to provide for a desired thickness or properties.

Abstract: Methods and systems for generating a model to be used for evaluating credit and loan applications are provided. The method includes: training a first model by using all features included in a universe of candidate features; measuring a first metric that relates to an accuracy of the first model and a second metric that relates to a disparity of the first model; constructing a graph based on pairwise correlations of the features; clustering the features into feature sets; estimating a respective disparity contribution associated with each feature set; selecting feature sets to be included in a second model; training, the second model; measuring the first metric and the second metric with respect to the second model; and determining whether the second model satisfies a predetermined accuracy level and a predetermined disparity reduction with respect to the first model.

Abstract: Systems and methods for frequency management, including: an online media service configured to: receive a request for a media item, the request including a recipient identifier; identify a set of candidate media items ranked by a set of matching criteria; a frequency management service configured to: perform a query against a lookup service, where the query includes (i) an entity identifier of at least one candidate media item of the set of candidate media items, and (ii) the recipient identifier; receive a response from the lookup service including a quantity of impressions associated with the entity identifier and the recipient identifier; identify a predefined frequency threshold; determine that the frequency threshold is exceeded and exclude the at least one candidate media item from a result set based on the determination; and provide the result set including an identifier of at least one other candidate media item.

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Abstract: A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.

Abstract: A food recycler can include a case having a case volume between 8.79 liters and 35 liters, a control system, a user interface in electrical communication with the control system, and a bucket being configured with a bucket volume, wherein a ratio of the bucket volume to the case volume is between 0.0717 and 0.2857. The recycler can include a motor in communication with the control system, the motor being configured adjacent at least in part to the bucket, a gearbox configured below the bucket and in mechanical communication with the motor, a filter system having at least one filter and configured to receive air from a top portion of the bucket and a drying component configured to remove water from waste food items.

Abstract: The invention provides anti-CfaE antibodies and methods of using the same.

Abstract: There is disclosed squaraine compounds of formula I: wherein each of Y1 and Y2 is independently chosen from an optionally substituted amino group and an optionally substituted aryl group. Also described are organic optoelectronic devices comprising a Donor-Acceptor heterojunction that is formed from one or more of the squaraine compounds. A method of making the disclosed device, which may include one or more sublimation step for depositing said squaraine compound, is also disclosed.