Abstract: The use of nondestructive inspection (NDI) capabilities for the detection of fatigue cracks extending from fastener holes in multi-layered metallic structures without removing the fastener; including at least the use of a probe guide containing a UT sensor and either an inertial measurement unit (IMU) or a rotary encoder, and either of these options could be applied in testing of either raised head fasteners or flush fasteners.

Abstract: A low-cost ultrasonic system and method that can be used during powder based fusion additive manufacturing to control the microstructural features of parts built in a metallic system. The system and method include the application of laser acoustic emission technology to monitor the metallic microstructure during a build. The system and method can be built into or added onto existing laser-based powder based fusion additive manufacturing machines.

Abstract: A method for treatment or prevention of a disease or disorder of an eye comprises (a) charging a dispenser with a suitable liquid medicament, (b) disposing the dispenser in operative juxtaposition with the eye, and (c) actuating the dispenser to release a therapeutically effective amount of the medicament into the eye. The dispenser comprises an electrically energizable droplet generating device, such as a thermal resistor bubble jet device, together with means for electrically energizing and means for actuating the device. The device, when actuated, is adapted to issue droplets of the liquid medicament at a rate of about 1 to about 300 ?l s?1 whereby a therapeutically effective amount of not more than about 50 ?l of the medicament is released into the eye in not more than about 1 second. The dispenser further comprises a standoff configured to engage a facial surface proximal to the eye, thereby placing the dispenser in operative juxtaposition with the eye.

Abstract: The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.