Patents by Inventor Mark Wayne LEE

Mark Wayne LEE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic-fused heteroaryl or aryl compounds
    Patent number: 12202836
    Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.
    Type: Grant
    Filed: June 28, 2023
    Date of Patent: January 21, 2025
    Assignee: Pfizer Inc.
    Inventors: John David Trzupek, Katherine Lin Lee, Mark Edward Bunnage, Seungil Han, David Hepworth, Frank Eldridge Lovering, John Paul Mathias, Nikolaos Papaioannou, Betsy Susan Pierce, Joseph Walter Strohbach, Stephen Wayne Wright, Christoph Wolfgang Zapf, Lori Krim Gavrin, Arthur Lee, David Randolph Anderson, Kevin Joseph Curran, Christoph Martin Dehnhardt, Eddine Saiah, Joel Adam Goldberg, Xiaolun Wang, Horng-Chih Huang, Richard Vargas, Michael Dennis Lowe, Akshay Patny
  • Process and device for the production of polyhedral boranes
    Patent number: 9598352
    Abstract: The present invention provides methods and devices for producing polyhedral boron compounds. The process is generally an anhydrous, one-pot process that comprises a pyrolytic reaction of a tetraborohydride with a quaternary amine salt to form the polyhedral borane. In another aspect of the present invention, polyhedral boranes are produced, without isolation of the Lewis base-borane complex.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: March 21, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Mark Wayne Lee, Marion Frederick Hawthorne
  • Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
    Patent number: 9382267
    Abstract: The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biological properties of the inventive cluster boron compounds, in terms of biological inhibition and antiproliferative effect, are greater than other small molecule inhibitors of Nampt.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: July 5, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Mark Wayne Lee, Jr., Yulia Sevryugina
  • Combinatorial therapy for treatment of osteoarthritis of the knee
    Patent number: 9226938
    Abstract: Embodiments of the present invention generally relate to methods of knee rehabilitation. Embodiments generally include the use of viscosupplementation delivered intra-articularly in conjunction with rehabilitative therapy and an unloading knee brace. The injection of the viscosupplementation is guided such that the entire dose is delivered to the joint and can flow tricompartmentally.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: January 5, 2016
    Assignee: RMG REHABILITATION MANAGEMENT GROUP, LP
    Inventors: Mark Wayne Lee, John Samuel Vick
  • SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
    Publication number: 20150322093
    Abstract: The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biological properties of the inventive cluster boron compounds, in terms of biological inhibition and antiproliferative effect, are greater than other small molecule inhibitors of Nampt.
    Type: Application
    Filed: November 28, 2012
    Publication date: November 12, 2015
    Inventors: Mark Wayne Lee, Jr., Yulia Sevryugina
  • MOBILE BASED EXERCISE AND REHABILITATION PRESCRIPTION TOOL AND APPLICATION
    Publication number: 20150269851
    Abstract: Embodiments generally relate to methods of visual delivery of prehab and rehabilitation. Embodiments generally include the use a remote device to receive visual instruction for prehab and rehabilitation. The visual instruction can be create during the interaction between the patient and the skilled provider. The visual instruction is created, modified or utilized by the patient under the direction of a skilled provider. Further, the visual instruction is modified based on feedback from the patient.
    Type: Application
    Filed: March 18, 2015
    Publication date: September 24, 2015
    Inventors: Mark Wayne LEE, Michael SLONIEWSKY
  • PROCESS AND DEVICE FOR THE PRODUCTION OF POLYHEDRAL BORANES
    Publication number: 20140378707
    Abstract: The present invention provides methods and devices for producing polyhedral boron compounds. The process is generally an anhydrous, one-pot process that comprises a pyrolytic reaction of a tetraborohydride with a quaternary amine salt to form the polyhedral borane. In another aspect of the present invention, polyhedral boranes are produced, without isolation of the Lewis base-borane complex.
    Type: Application
    Filed: November 16, 2012
    Publication date: December 25, 2014
    Inventors: Mark Wayne Lee, Marion Frederick Hawthorne
  • COMBINATORIAL THERAPY FOR TREATMENT OF OSTEOARTHRITIS OF THE KNEE
    Publication number: 20140276312
    Abstract: Embodiments of the present invention generally relate to methods of knee rehabilitation. Embodiments generally include the use of viscosupplementation delivered intra-articularly in conjunction with rehabilitative therapy and an unloading knee brace. The injection of the viscosupplementation is guided such that the entire dose is delivered to the joint and can flow tricompartmentally.
    Type: Application
    Filed: August 2, 2013
    Publication date: September 18, 2014
    Applicant: RMG Rehabilitation Management Group, LP
    Inventors: Mark Wayne LEE, John Samuel VICK