Patents by Inventor Mark Welch

Mark Welch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Subtilisin variants
    Publication number: 20030049827
    Abstract: New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.
    Type: Application
    Filed: April 2, 2001
    Publication date: March 13, 2003
    Inventors: Jon E. Ness, Mark Welch, Lorraine J. Giver, Joel R. Cherry, Torben V. Borchert, Willem P.C. Stemmer, Jeremy Minshull
  • Oligonucloetide mediated nucleic acid recombination
    Patent number: 6521453
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: February 18, 2003
    Assignee: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 6479652
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: November 12, 2002
    Assignee: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Biosensors, reagents and diagnostic applications of directed evolution
    Publication number: 20020127623
    Abstract: Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.
    Type: Application
    Filed: July 31, 2001
    Publication date: September 12, 2002
    Applicant: Maxygen, Inc.
    Inventors: Jeremy Minshull, S. Christopher Davis, Mark Welch, Sun Ai Raillard, Kurt Vogel, Claus Krebber
  • Use of codon-varied oligonucleotide synthesis for synthetic shuffling
    Patent number: 6436675
    Abstract: Methods of providing shuffling libraries that include codon-varied oligonucleotide sequences are described. Codon-varied oligonucleotides are synthesized using trinucleotide or mononucleotide phosphoramidite sequences, and are derived from homologous or non-homologous nucleic acid sequences, or combinations of such sequences. Various methods of recombining codon-varied oligonucleotide sequences to expedite artificial evolution are also described. The present invention additionally relates to various integrated systems that are optionally used to automate these recombination methods.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: August 20, 2002
    Assignee: Maxygen, Inc.
    Inventors: Mark Welch, Jon Ness, Claes Gustafsson, Willem P. C. Stemmer, Jeremy Minshull
  • Nucleotide incorporating enzymes
    Publication number: 20020102577
    Abstract: Nucleotide incorporating enzyme variants having improved properties including the ability to utilize non-natural or rare nucleotide analogues in the synthesis of polynucleotides are provided. Methods for producing such nucleotide incorporating enzyme variants are provided, as are kits and integrated systems including the nucleotide incorporating enzyme variants.
    Type: Application
    Filed: July 31, 2001
    Publication date: August 1, 2002
    Inventors: Sun Ai Raillard, Mark Welch, Jon Ness
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 6426224
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: July 30, 2002
    Assignee: MaxyGen, Inc.
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 6423542
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: July 23, 2002
    Assignee: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 6376246
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: April 23, 2002
    Assignee: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 6368861
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: April 9, 2002
    Assignee: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 6319714
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: November 20, 2001
    Assignee: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P.C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Integrated systems and methods for diversity generation and screening
    Publication number: 20010039014
    Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
    Type: Application
    Filed: January 10, 2001
    Publication date: November 8, 2001
    Applicant: Maxygen, Inc.
    Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P.C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
  • Safety monitor
    Patent number: 5774038
    Abstract: The present invention relates to a improved safety monitor (10) which comprises a main monitor (12) and a remote monitor (14) which are in two way communication with each other. The main monitor (12) has a main monitor detector (12J) and a main monitor fire/smoke alarm (12K) integrally electronically connected to a main monitor microprocessor (12F). The main monitor detector (12J) is selected from a group consisting of monitor carbon monoxide detector, monitor carbon dioxide detector, and monitor radon detector. The main monitor detector (12J) and the main monitor fire/smoke alarm (12K) send a warning signal to the remote monitor (14) to alert the user of an adverse condition and which type. A charger base (16) is provided to hold the main monitor (12) and the remote monitor (14) as well as charge the main monitor battery (12I) and remote monitor battery (14I).
    Type: Grant
    Filed: July 1, 1996
    Date of Patent: June 30, 1998
    Inventors: Dana L. Welch, Mark A. Welch, Shirley A. McCoy