Abstract: Methods of treating a subject for a bone marrow failure syndrome, e.g., DBA, are provided. Aspects of the methods include administering to the subject an effective amount of a Nemo-Like Kinase (NLK) inhibitor. Also provided are compositions that find use in practicing embodiment of the invention.

Abstract: A helmet includes an outer shell and an impact absorbing layer adjacent to the outer shell. The helmet also includes a fit system mounted to the impact absorbing layer. The fit system includes a rear portion that includes a rotational mount having a ball and an extension mounted to the ball. The fit system also includes a rear mount that includes a plurality of grooves. Each groove in the plurality of grooves is configured to receive the rotational mount of the rear portion of the fit system.

Abstract: A steering column assembly includes a housing, a shaft, a sensor, a motor, an elongate rod, a nut member, an actuator housing, and end stops. The shaft may be attached to an end of a steering wheel. The sensor may generate an electrical signal in response to rotation of the rotatably mounted shaft. The motor may apply a torque to the rotatably mounted shaft. The elongate rod may be configured to rotate with the rotatably mounted shaft and may include an externally screw-threaded portion having a nut member mounted thereon. The actuator housing may define a chamber to house the motor and a cavity which restricts rotation of the nut member with respect to the housing. The rotation of the elongate rod causes axial displacement of the nut member. The end stops may engage with the nut member.

Abstract: An apparatus including a hub shell. The hub shell can include a hub body; a first spoke flange; and a second spoke flange. The first spoke flange and the a second spoke flange can include a fiber reinforced plastic. The fiber reinforced plastic can include fibers having a range of lengths between 0.2 and 3 inches.

Abstract: A steering column assembly includes a bracket for securely fixing a steering lock mechanism to the shroud of the steering shaft. The lock mechanism includes a bolt that projects in a locked position to act upon the shaft to limit rotation. The bracket is secured to the shroud in such a way that it is free to move relative to the shroud against a spring force. This helps the lock resist an attack using a high impact force.

Abstract: An apparatus including a hub shell. The hub shell can include a hub body; a first spoke flange; and a second spoke flange. The first spoke flange and the a second spoke flange can include a fiber reinforced plastic. The fiber reinforced plastic can include fibers having a range of lengths between 0.2 and 3 inches.

Abstract: An apparatus including a bicycle wheel rim. At least a portion of the bicycle wheel rim can include a braking material. The braking material can have a roughness of about 1 micron to about 80 microns.

Abstract: This invention relates to a method of lubricating an internal combustion engine comprising at least one of a crankcase, a gear and a wet-clutch, said method comprising supplying to said crankcase, gear, and wet-clutch a lubricating composition containing: (a) an oil of lubricating viscosity; (b) a boron containing compound; and (c) a friction modifier.

Abstract: This invention relates to a method of lubricating an internal combustion engine comprising at least one of a crankcase, a gear and a wet-clutch, said method comprising supplying to said crankcase, gear and wet-clutch a lubricating composition comprising: (a) an oil of lubricating viscosity; and (b) a viscosity modifier with a number average molecular weight from 1000 to 75,000, wherein the lubricating composition has a SAE viscosity grade from XW—Y, wherein X is from 0 to 20 and Y is from 20 to 50; and wherein the lubricating composition has a phosphorus content from a metal hydrocarbyl dithiophosphate of 0.12 wt % or less.

Abstract: The present invention provides a method of asphaltene control in a hydrocarbon fluid, the method employing a composition comprising: a dispersant of formulae (I) or (II), including salts thereof, wherein T or T? is hydrogen or a polymerizing terminating group; A is C16-20 alkylene or alkenylene group; B is C10-20 alkylene or alkenylene group; Z and Z? are the residue of a polyamine or polyimine; n is 2 to 50; m is 0 to 25; p and p? are 2 or more, in one embodiment not greater than 2000 and in another embodiment not greater than 1000; A? is C8-20 alkylene or alkenylene group; n? is 2 to 10; and the weight ratio of T-(O-A-CO)n (O—B—CO)m to Z or T?-(O-A?-CO)n to Z? is at least 5:1.

Abstract: An assembly comprises a male component and a female component which connect together to form a mechanical connection, the female component being adapted to at least partially receive an end portion of the male component. The female component has at least one bore which is adapted to receive a clamping pin which can be tightened to clamp the female component around the male component. A guide is provided which is carried by the male component and which defines at least one blocking region and one opening region, the opening region being aligned with the at least one bore in the female component to permit insertion of the clamping pin into the bore when the male component and female component are correctly aligned and the blocking region otherwise preventing insertion of the clamping pin when the male component is inserted into the female component with an incorrect alignment. The guide assists in achieving correct alignment of the male and female components during assembly.

Abstract: A catheter protector designed to be of assistance to patients using a Peripherally insterted central catheter. The catheter is inserted into a vein in the patients arm, usually at the elbow. The catheter has an attached tube which is usually pinched off. The protector can be an elastic tubular sleeve with a zipper or other attachment means at its lower end running longitudinally to a point one-half to three-quarters of the way up the bottom half of the tube. The zipper or attachment is opened, and the sleeve is slipped over the catheter. The attached tube can then be coiled up inside the sleeve and the zipper closed. The device protects the site and tube against pulling and contamination. The zipper or attachement can be opened any time to administer drugs or replace the catheter. The device can optionally contain an inner plastic layer with an optionally inner layer of gauze to further protect the insertion site. The invention can be worn 24 hours a day including wear during bathing.

Abstract: A catheter protector designed to be of assistance to patients using a Peripherally insterted central catheter. The catheter is inserted into a vein in the patients arm, usually at the elbow. The catheter has an attached tube which is usually pinched off. The protector can be an elastic tubular sleeve with a zipper or other attachment means at its lower end running longitudinally to a point one-half to three-quarters of the way up the bottom half of the tube. The zipper or attachment is opened, and the sleeve is slipped over the catheter. The attached tube can then be coiled up inside the sleeve and the zipper closed. The device protects the site and tube against pulling and contamination. The zipper or attachement can be opened any time to administer drugs or replace the catheter. The device can optionally contain an inner plastic layer with an optionally inner layer of gauze to further protect the insertion site. The invention can be worn 24 hours a day including wear during bathing.