Abstract: A silicon photonic device includes a substrate formed from a silicon-containing material and patterned to comprise a first waveguide and a second waveguide defining a first trench extending between the first waveguide and the second waveguide. The first waveguide and second waveguide have upper surfaces exposed for bonding to an epitaxially grown layer. The first trench being exposed to the epitaxially grown layer. A support structure is formed within the first trench and extends upward to an upper surface at a height of the upper surfaces of the first waveguide and second waveguide. The support structure is optically non-functional.

Abstract: Novel and known substituted purine compounds and salts thereof act as adenosine A2a receptor (A2aR) antagonists for cancer immunotherapy, depression, anxiety, multiple sclerosis, NASH, scleroderma, ADHD, Alzheimer's and Parkinsons. Pharmaceutical compositions comprising such compounds, and methods of their use in treating depression are also taught.

Abstract: The present disclosure is directed to a mammalian cell comprising an arthropod chemosensory receptor and its uses in methods of identifying repellents and attractants or traps for use in an arthropod control article comprising an arthropod control composition. The cell may be contained in a cell-based assay or disposed on a solid support.

Abstract: Compositions of particles having at least 95% by weight of cisplatin and a specific surface area (SSA) of at least 3.5 m2/g. methods for their use. and methods for their production are provided.

Abstract: The use of glutamate 2b receptor antagonists and sigma receptor agonists as antitussives to treat or prevent a cough is disclosed. In preferred embodiments, the glutamate 2b receptor antagonist is ifenprodil or radiprodil. Preferred sigma receptor agonists include fluvoxamine, fluoxetine, excitalpram, and donepezil.

Abstract: Purine compounds and salts thereof act as adenosine A2a receptor (A2aR) antagonists for treating cancer immunotherapy, depression, anxiety, multiple sclerosis, NASH, scleroderma, ADHD, Alzheimer's and Parkinson's. Pharmaceutical compositions comprising such compounds, and methods of their use in treating depression are also taught. Form. (I) & (II).

Abstract: The use of glutamate 2b receptor antagonists and sigma receptor agonists as antitussives to treat or prevent a cough is disclosed. In preferred embodiments, the glutamate 2b receptor antagonist is ifenprodil or radiprodil. Preferred sigma receptor agonists include fluvoxamine, fluoxetine, excitalpram, and donepezil.

Abstract: A suspension system for skateboards that provides a low profile, high strength suspension system to support a typical roller skate which incorporates one independent and/or offset style suspension and one offset style suspension which includes a flat plate next to a cover with apertures; two support posts secured and configured perpendicularly to the flat plate, where each post has either a drive stud at one end and an aperture and bearing at an opposite end to the flat plate and drive stud; a torsion arm with a socket to connect to the drive stud; and a hub base that encircles the torsion arm opposite the socket which secures the hub base to the torsion arm while the hub base is removably secured to a stub shaft; a way to attach the flat plate and a second way for removably connecting the cover to the skate base plate.

Abstract: A lamp body to be releasably coupled to a mounting surface. The lamp body comprises a mount post and a cantilevered lock. The mount post is configured to be received in a mounting hole in the mounting surface, where the mount post is configured to slide between a releasing portion of the mounting hole and a locking portion of the mounting hole. The cantilevered lock is configured to releasably engage with a stop on the mounting surface when the mount post slides into the locking portion of the mounting hole to retain the mount post within the locking portion of the mounting hole.

Abstract: The present disclosure generally provides methods for identifying compounds that attenuate the bitter taste of active pharmaceutical ingredients (APIs). In some aspects, the disclosure provides methods of identifying compounds that attenuate the bitter taste of APIs by determining whether the compounds modulate certain T2R bitter taste receptors. In some other aspects, the disclosure provides uses of such identified compounds to attenuate the bitter taste of an ingestible composition that comprises one or more APIs, such as liquid or solid dosage forms for oral administration. In some further aspects, the disclosure provides flavored products, such as pharmaceutical products, that incorporate such ingestible compositions.

Abstract: There is provided a system (900) and a vehicle (1). The system (900) comprises a front crossmember (810) for the vehicle (1), and a bumper rail (840) for positioning a front bumper assembly (8, 8A) of the vehicle (1). The front crossmember (810) comprises: a first body fixing point (812) securable to a vehicle body (100) of the vehicle (1) at a first lateral side of the vehicle body (100); a second body fixing point (812) securable to the vehicle body (100) at a second lateral side of the vehicle body (100); and bumper rail fixing points (824) configured to receive the bumper rail (840). The bumper rail (840) comprises: bumper assembly positioning points (858A, 858B) for setting a position of the front bumper assembly (8, 8A) in a direction; and a ranging sensor mount (854) to support a ranging sensor (860).

Abstract: A lamp body to be releasably coupled to a mounting surface. The lamp body comprises a mount post and a cantilevered lock. The mount post is configured to be received in a mounting hole in the mounting surface, where the mount post is configured to slide between a releasing portion of the mounting hole and a locking portion of the mounting hole. The cantilevered lock is configured to releasably engage with a stop on the mounting surface when the mount post slides into the locking portion of the mounting hole to retain the mount post within the locking portion of the mounting hole.

Abstract: A heat extraction system for extracting heat from a reservoir, the system including a co-axial tool configured to be placed underground, the co-axial tool having an outer pipe and an inner pipe located within the outer pipe, each of the outer pipe and the inner pipe being connected to a shoe so that a fluid flows through an annulus defined by the inner and outer pipes, reaches the shoe, and flows through a bore of the inner pipe; and a power generator fluidly connected to a chemical processing unit to receive a fluid, and also fluidly connected with a first port to the inner pipe and with a second port to the outer pipe of the co-axial tool. A temperature difference of the fluid at the power generator and at the co-axial tool drives the power generator to generate energy.

Abstract: An electronic access control system and method that enables conditional access to electronic locking systems according to user-based and situation-based safety parameters. Aspects of the present disclosure provide for a mobile access interface whereby the network operations center can assess a safety risk for a service site based on a combination of user-generated inputs, sensor inputs and/or external data inputs. The system may comprise a dynamic rules engine configured to dynamically determine safety and compliance associated with an access-restricted area. If the access-restricted area is safe, the system may enable access according to one or more access protocols. If the access-restricted area is unsafe, or the user requesting access is not in compliance with one or more static or dynamic safety parameters, the system may disable standard access protocols and deny access to the requesting party.

Abstract: Compounds for the prevention and treatment of cancer have a first binding peptide from a urokinase-type plasminogen receptor (uPAR) antagonist operatively linked to an antibody peptide operatively linked to a second binding peptide from an endostatin or plasminogen derived peptide sequence.

Abstract: The present disclosure generally relates to the expression of T1R1+3 taste receptors in eukaryotic cells, such as U2OS cells. The disclosure also relates to the expression of a chimeric T1R3 taste receptor subunit to enable the T1R1 taste receptor subunit to achieve a higher level of sensitivity to umami compounds. Also disclosed are methods of expressing T1R1+3 taste receptors in such cells, and methods of screening for substances that modulate T1R1+3 receptor sensing, and which, therefore, may be useful as modulators of umami taste.

Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

Abstract: Iguratimod, Repirinast, Lobenzarit, Actarit, Ifenprodil, Bemithyl, Bromantane, Emoxypine, Udenafil, and/or Istradefylline are used for the treatment or prophylaxis of renal fibrosis, kidney disease, or chronic kidney disease in a subject.

Abstract: A heat extraction system for extracting heat from a reservoir, the system including a co-axial tool configured to be placed underground, the co-axial tool having an outer pipe and an inner pipe located within the outer pipe, each of the outer pipe and the inner pipe being connected to a shoe so that a fluid flows through an annulus defined by the inner and outer pipes, reaches the shoe, and flows through a bore of the inner pipe; and a power generator fluidly connected to a chemical processing unit to receive a fluid, and also fluidly connected with a first port to the inner pipe and with a second port to the outer pipe of the co-axial tool. A temperature difference of the fluid at the power generator and at the co-axial tool drives the power generator to generate energy.

Abstract: A geothermal plant, for extracting energy from a geothermal reservoir located below the ocean bottom, includes a floating platform; a riser that extends from a well drilled into the geothermal reservoir, to the floating platform; an electrical pump having a mechanical actuation part located in a bore of the riser, and an electronic part located outside the riser, wherein the electrical pump is configured to pump a geothermal liquid from the geothermal reservoir to the floating platform; and a power plant located on the floating platform and configured to use a steam produced by the geothermal liquid to generate electrical power. The electrical pump is placed at a depth of the riser where the geothermal liquid is in a single-phase.