Abstract: A delivery pen includes a reservoir including a non-circular shape, a plunger positioned in the reservoir, and a screw mechanism at least partially inserted within the reservoir. The screw mechanism includes a drive shaft including one or more protruding member at a proximal end and an elongated member extending longitudinally from the proximal end, an inner screw concentrically engaging the elongated member, an outer housing including a circular section rotatably engaging the one or more protruding member and a non-circular section sized to fit within the reservoir, and a pusher disposed between the inner screw and the outer housing to linearly translate the plunger so as to dispense a medication from the reservoir.

Abstract: The invention provides an antifungal composition comprising an antifungal compound of formula R—S+(R?)2 or R—N+(R?)3 wherein R is C17-C32 straight chain or branched alkyl; and each R? is independently methyl, ethyl, propyl, isopropyl or butyl; and uses of said composition as antifungal agents.

Abstract: A pump subsystem for fluid delivery (e.g., in a wearable patch pump) is provided wherein pumping action is generated by linear piston movement that pulls a plug, which is interconnected to the piston between two mechanical extremes or end stops in a telescopic or variable volume fluid chamber. Such interconnection enables piston and plug to move a certain distance with respect to each other that corresponds to a predefined swept volume of the pump subsystem. Telescoping-like effect of relative piston and plug movement provides for intake and discharge of fluid with respect to the fluid chamber. Movement of plug within piston can be enabled by the friction of seals placed on the plug, which serve to provide resistance to piston motion and therefore force translation motion of the plug to lag relative to the piston translation motion during portions of the pump cycle.

Abstract: A floating barrier system has a plurality of connected floating barrier units. Capture net segments are positioned on the floating barrier units by support post members, forming a barrier to vessel passage. Lanyards attach the ends of the capture net segments to the floating barrier units. Upon a vessel striking the capture net segments with sufficient force, the capture nets detach from the support post members and/or pull the support post members over, and the forces from the vessel are transferred via the lanyards to the floating barrier unit. The vessel is prevented from fully passing over the floating barrier unit, thus itself forming a barrier to passage by other vessels.

Abstract: Pump subsystem for fluid delivery (e.g., in a wearable patch pump) comprises a fluid chamber with pumping motion and a valve shaft assembly with valving motion, both being driven by the same drive mechanism. Fluid chamber has variable volume chamber provided by a piston driven by the drive mechanism and translated relative to a plug in the pump housing. Piston extends the fluid chamber during an intake stroke and retracts the fluid chamber during a discharge stroke. Valve assembly has at least one valve shaft controllably translated by the drive mechanism to selectively align a first throughway with an opening in the pump chamber and a fluid intake port for an intake stroke to draw fluid into the fluid chamber, and align a second throughway with the opening in the pump chamber and a fluid discharge port for an discharge stroke to discharge fluid from the fluid chamber.

Abstract: The present disclosure relates to systems and methods for providing cybersecurity functionality to computer implemented inventions such as Internet of Thing (IoT) systems and object devices, and more specifically, to an improved cybersecurity system, method and capabilities for the protecting IoT and similar devices through non-discriminatory vendor/supplier independent distribution of secure predetermined IoT syndication data to unidentified and non-registered IoT devices, through the use of a passive data distribution technology and out-of-band, system-to-device distribution channel and no peer-to-peer stateless relationship with the receiving device and using Quality of Service (QoS) and enabling the determination as to whether there is any suspicious activity occurring and prohibiting the IoT device from taking any customer-defined action without have a separately provided authentication.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger and plunger driver assembly comprising nested, telescopic screws comprising an innermost screw keyed to a first side of the plunger or intermediate pusher to prevent rotation. In a fully retracted position, the nested screws do not extend into the reservoir. The nested screws all have right handed threads and employ the same pitch in their respective inner thread and outer thread designs. The outermost screw is connected to a motor for controllable rotation. The decreasing torque ratios from the outermost to innermost screw member and anti-rotation feature allows the innermost screw to advance the plunger into the reservoir before the adjacent concentric screw member commences rotating and advancing within its corresponding screw, and so on, to translate the plunger and expel fluid in a fluid chamber defined on the other, second side of the plunger.

Abstract: Certain embodiments of the invention provide ionizable lipids having optimized clearance properties. Certain embodiments of the invention also provide nucleic acid-lipid particles comprising ionizable lipids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.

Abstract: Certain embodiments of the invention provide a cationic lipid of formula (I): wherein R1, R2, R3 and R4 are defined as described herein, as well as methods of making these lipids. Certain embodiments of the invention also provide nucleic acid-lipid particles comprising a cationic lipid of formula (I), methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.

Abstract: This invention presents a portable, battery-operated ultraviolet biofluid and fluid irradiating device, designed for deactivating pathogens in biofluids and non-terrestrial ice slurry or soil using UV LEDs. Ideal for battlefield, emergency scenarios, and low gravity or no gravity scenarios such as space travel and non-terrestrial environments. It features a microcassette for biofluid handling and PCR analysis with or without necessity for adjuvants. The device is compact, lightweight, rugged, and suitable for rapid transfusions, revolutionizing field medical care with its innovative and versatile technology which may further be adapted for non-terrestrial ice/fluid processing.

Abstract: The invention provides PEG-conjugated lipids of formula (I): A-B-C (I) wherein A, B, and C have any of the values defined in the specification, as well as compositions comprising the PEG-conjugated lipids of formula (I), nucleic acid lipid nanoparticles comprising the PEG-conjugated lipids of formula (I), and methods of using the PEG-conjugated lipids of formula (I), the compositions, and the nucleic acid nanoparticles.

Abstract: A catheter insertion device is provided as an external applicator attachable to a medicine delivery device. The medicine delivery device has an internal module therein that comprises an insertion needle hub and needle, and a catheter hub and catheter. An external applicator comprises a drive and spring that drive a drive pin into the medicine delivery device to force the needle hub and catheter hub downward until the catheter hub locks in the downward position and the needle hub returns into the external applicator. An automatic release feature automatically disengaged the external applicator from the medicine delivery device when insertion is complete.

Abstract: Certain embodiments of the invention provide a cationic lipid of formula (I): wherein R1, R2, R3 and R4 are defined as described herein, as well as methods of making these lipids. Certain embodiments of the invention also provide nucleic acid-lipid particles comprising a cationic lipid of formula (I), methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.

Abstract: The invention provides compounds of formula (I) and salts thereof, wherein R1, L1, A, RA, n, L2, and R2 have any of the values defined in the specification, as well as compositions comprising the compounds and methods for their use.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger and plunger driver assembly comprising nested, telescopic screws comprising an innermost screw keyed to a first side of the plunger or intermediate pusher to prevent rotation. In a fully retracted position, the nested screws do not extend into the reservoir. The nested screws all have right handed threads and employ the same pitch in their respective inner thread and outer thread designs. The outermost screw is connected to a motor for controllable rotation. The decreasing torque ratios from the outermost to innermost screw member and anti-rotation feature allows the innermost screw to advance the plunger into the reservoir before the adjacent concentric screw member commences rotating and advancing within its corresponding screw, and so on, to translate the plunger and expel fluid in a fluid chamber defined on the other, second side of the plunger.

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: A fluid delivery device (FDD) has a reservoir, a driver assembly, and a controller to controllably deliver fluid from the reservoir into a patient. The controller is configured to support dosing control and other operations of the fluid delivery device by a connected auxiliary device such as a smartphone or other portable remote control device. Active safety features are provided for commands to the fluid delivery device that comprise: (1) at least anomaly detection for inputted FDD commands and prompt for confirmation of anomalous commands prior to commanded operation of the FDD; and (2) an optional secondary communication path or modality for the confirmation that is different from a first communication path or modality used to communicate the command to the FDD.

Abstract: The disclosure provides driver components and methods of operating same that provide a reduced form factor for pen-type injection devices. In particular, various multi-piece telescoping plunger rod configurations are disclosed that can be implemented within pen-type injection devices to achieve such improvements. Driver components replace a single plunger rod having fixed length with telescoping pieces that are controlled to at least partially extend axially to dispense fluid from the reservoir or cartridge.

Abstract: A device assembly having a syndicated data service interface that is communicatively coupled to a vendor-specific syndicated data application platform and having an installed vendor specific syndicated data application, with the interface receiving point-to-multipoint non-addressed transport bearer channels of different syndicated data channel transport networks initially only including the monitoring of the syndicated data channels and not decoding the syndicated data messages or syndicated data informational data contained therein, identifying from the transport bearer channels a received syndicated data channel having an syndicated data channel identifier of the specific syndicated data device, and reading the syndicated data messages within the received syndicated data channel and extracting the syndicated data supplier-independent informational data from the syndicated data message and providing the extracted syndicated data informational data to at least one of the installed vendor specific syndicated d

Abstract: The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).