Abstract: A one-sided fastener assembly for use in coupling an assembly stack-up includes a sleeve comprising an outer cylindrical surface and an inner tapered surface oriented at a first angle with respect to the outer surface. The inner tapered defines an opening extending through the sleeve. The fastener assembly also includes a core extending along an axis and configured for insertion into the opening. The core includes an outer tapered surface oriented at a second angle with respect to the axis configured for engagement with the sleeve inner tapered surface such that insertion of the core into the sleeve causes radial expansion of the sleeve creating an interference fit with the assembly stack-up to complete installation of the one-sided fastener assembly.

Abstract: Release mechanism for medical device includes a bushing having a proximal end, a distal end and a channel extending therethrough. Plurality of extend proximally from the distal end are biased toward a release configuration in which engagement surfaces at distal ends thereof retract radially into the channel. A core pin insertable through the channel applies a radially expansive pressure to move the arms radially outward to a locking configuration. Engagement surfaces of the first and second arms connect to a retaining surface of a tissue treatment device containing capsule, which extends at an angle relative to the engagement surfaces selected so that a first portion of a force transmitted along an axis of the bushing moves the arms radially inward toward the release configuration before a second portion of the force exceeds a threshold level associated with the removal of a tissue treatment device from gripped tissue.

Abstract: The application discloses integrated air suspension and platform lifting systems that utilize an existing air supply for lifting one or more platforms installed in a trailer or hauling vehicle. An apparatus for lifting a rear gate or platform of a trailer or a hauling vehicle is disclosed that includes an actuating mechanism operable to pivot the platform between a lowered position (e.g., where the end of the platform is in contact with the ground) and a range of raised positions (e.g., where the platform is raised to meet an elevated platform such as a loading dock). The lifting mechanisms for raising and lowering the platform(s) may utilize a pressurized gas supply from a compressor. In some embodiments, the lifting mechanism may be supplied with pressurized air from a compressor of a brake system of a tractor. In some embodiments a separate locking mechanism is provided to hold the platform in place after the lifting system has moved it into a desired position.

Abstract: The preferred embodiment of the present invention provides a system and method for programming and/or charging one or more audio/video devices such that the audio/video devices will be programmed and charged to receive transmitted audio and video signals associated with an event, allowing a user to use the audio/video device to observe the sights and sounds of the event. A preferred embodiment of the present invention includes a cart with a docking port for each of a plurality of personal audio/video devices, a charger configured to charge the power source of each personal audio/video display device, and programming logic configured to program each of the personal audio/video devices.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: A two-piece, one-sided-installation fastener system may have an internally-threaded sleeve having a shank and a sleeve head. The fastener system may include an externally-threaded core bolt having a frangible driving provision and a core bolt head.

Abstract: A joint fastening system employs a lock bolt having a pull stem and locking threads inserted through a bore in a joint having fay sealant between layers. A collar is received over the pull stem to engage the threads, the collar producing tension on the threads to generate clamp force sufficient for fay sealant squeeze out.

Abstract: Implantable medical devices and methods for making and using the same are disclosed. An example implantable medical device may include a stent having a first configuration and a second expanded configuration. The stent may define a plurality of nodes. The stent may have a cover member disposed adjacent the nodes. The cover member may be configured to cover at least some of the nodes when the stent is in the expanded configuration.

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract: A system and method for providing content for access by a portable device at an event are provided. The system includes an interface to receive signals from a plurality of sources. The plurality of sources are located at an event and remote from the event. The signals define event content and non-event content. The system further includes a processor for processing the received signals to generate combined signals based upon the received signals from the plurality of sources. The system also includes a transmitter for transmitting to a plurality of portable devices at the event the combined signals. The combined signals are configured to allow a user to select content using the portable device receiving the combined signals.

Abstract: A foot for a pan support of a home appliance is provided. The foot includes an insertion portion at a first end of the foot for inserting into a recess in the pan support; and a lower portion adjacent the insertion portion, the lower portion having a compression edge at a second end of the foot opposite the first end in a longitudinal direction of the foot. The compression edge is adapted to deform under the weight of the pan support when the foot is received by a flat receiving surface of the home appliance.

Abstract: A two-piece, one-sided-installation fastener system may have an internally-threaded sleeve having a shank and a sleeve head. The fastener system may include an externally-threaded core bolt having a frangible driving provision and a core bolt head.

Abstract: A lung volume reduction system includes a percutaneously, laparoscopically or thorocospically insertable delivery element comprising a control end which remains outside the body and an insertion end which, when in an operative position, is adjacent to an external surface of a target portion of a lung and a constriction element deployable from the distal end of the delivery element to apply compressive force to an external surface of the target portion of the lung to constrict at least one airway therein and collapse the target portion of the lung.

Abstract: Implantable medical devices and methods for making and using the same are disclosed. An example implantable medical device may include a stent having a first configuration and a second expanded configuration. The stent may define a plurality of nodes. The stent may have a cover member disposed adjacent the nodes. The cover member may be configured to cover at least some of the nodes when the stent is in the expanded configuration.

Abstract: The application discloses integrated air suspension and platform lifting systems that utilize an existing air supply for lifting one or more platforms installed in a trailer or hauling vehicle. An apparatus for lifting a rear gate or platform of a trailer or a hauling vehicle is disclosed that includes an actuating mechanism operable to pivot the platform between a lowered position (e.g., where the end of the platform is in contact with the ground) and a range of raised positions (e.g., where the platform is raised to meet an elevated platform such as a loading dock). The lifting mechanisms for raising and lowering the platform(s) may utilize a pressurized gas supply from a compressor. In some embodiments, the lifting mechanism may be supplied with pressurized air from a compressor of a brake system of a tractor. In some embodiments a separate locking mechanism is provided to hold the platform in place after the lifting system has moved it into a desired position.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.

Abstract: Embodiments of the disclosure include devices and systems for using an end effector. In an embodiment, a medical device may include an articulation section. The articulation section may be operatively associated with an elongate articulation member configured to move the articulation section, wherein the articulation section can be configured to receive part of a conductive member. The medical device may also include an end effector. The end effector may include an electrode and a non-conductive section encasing a junction between the electrode and the conductive member, wherein the non-conductive section can be moveably coupled to the articulation section and can be fixedly coupled to the elongate articulation member.

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract: The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provided cationic lipids that are useful for preparing the compositions of the invention.

Abstract: A system and method for providing content for access by a portable device at an event are provided. The system includes an interface to receive signals from a plurality of sources. The plurality of sources are located at an event and remote from the event. The signals define event content and non-event content. The system further includes a processor for processing the received signals to generate combined signals based upon the received signals from the plurality of sources. The system also includes a transmitter for transmitting to a plurality of portable devices at the event the combined signals. The combined signals are configured to allow a user to select content using the portable device receiving the combined signals.