Abstract: The present disclosure relates to a method of identifying an agent-of-interest that alters binding or activity of a client protein to a chaperone, co-chaperone, or chaperone-co-chaperone complex, the method including: determining a three-dimensional (3D) structure of a client protein-of-interest; evaluating the 3D structure of the client protein-of-interest to identify an unstable substructure of the 3D structure of the client protein-of-interest; and determining an amino acid sequence of the unstable substructure of the 3D structure of the client protein-of-interest to identify an agent-of-interest that alters binding or activity of a client protein to a chaperone, co-chaperone, or chaperone-co-chaperone complex.

Abstract: In one embodiment, a method is provided for performing computed tomography (CT) imaging. The method includes obtaining EKG gating information from an object and obtaining attenuation measurements from the object utilizing a detector that is rotated in a scan plane around the object. The method further includes performing a first reconstruction based on a first portion of the attenuation measurements that are collected by a first region of the detector, where the first reconstruction is performed independent of the EKG gating information to obtain a first reconstruction data set. A second reconstruction is performed based on a second port of the attenuation measurements that are collected by a second region of the detector, where the second reconstruction is performed based on the EKG gating information to obtain a second reconstruction data set.

Abstract: In one embodiment, a method is provided for performing computed tomography (CT) imaging. The method includes obtaining EKG gating information from an object and obtaining attenuation measurements from the object utilizing a detector that is rotated in a scan plane around the object. The method further includes performing a first reconstruction based on a first portion of the attenuation measurements that are collected by a first region of the detector, where the first reconstruction is performed independent of the EKG gating information to obtain a first reconstruction data set. A second reconstruction is performed based on a second port of the attenuation measurements that are collected by a second region of the detector, where the second reconstruction is performed based on the EKG gating information to obtain a second reconstruction data set.

Abstract: A multi-sector back-off logic algorithm for obtaining optimal slice-sensitive computed tomography (“CT”) profiles. The systems and methods of the present invention improving the temporal resolution of a CT system by checking for Z location errors between sectors and automatically backing-off to an alternative multi-sector algorithm when necessary (i.e., selecting an optimized maximum number of sectors to reconstruct), providing less Z location error. Based upon this Z location error, the systems and methods of the present invention also calculating the maximum number of sectors that should be used for reconstruction “on-the-fly” (i.e., on a per image basis across an entire series of images). These systems and methods utilizing the Recommended Protocol for Cardiac Reconstruction Algorithms.

Abstract: A multi-sector back-off logic algorithm for obtaining optimal slice-sensitive computed tomography (“CT”) profiles. The systems and methods of the present invention improving the temporal resolution of a CT system by checking for Z location errors between sectors and automatically backing-off to an alternative multi-sector algorithm when necessary (i.e., selecting an optimized maximum number of sectors to reconstruct), providing less Z location error. Based upon this Z location error, the systems and methods of the present invention also calculating the maximum number of sectors that should be used for reconstruction “on-the-fly” (i.e., on a per image basis across an entire series of images). These systems and methods utilizing the Recommended Protocol for Cardiac Reconstruction Algorithms.

Abstract: In one aspect, the present invention is a method for scanning an object with a multi-slice CT imaging system having multiple detector rows each having an isocenter. The method includes steps of helically scanning an object with the multi-slice CT imaging system to obtain data segments including peripheral data segments, combining data from a first peripheral data segment with an opposite, second peripheral segment to form a data set for reconstruction of an image slice; and reconstructing the combined data into image slices.

Abstract: In one aspect, the present invention is a method for producing CT images of a patient's heart suitable for calcification scoring, in which the heart has a cardiac cycle. The method includes steps of acquiring data representative of a first scout-scanned CT image of physical locations of the patient's body including at least a portion of the patient's heart at phases &phgr;1(L) of the cardiac cycle, acquiring data representative of a second scout-scanned CT image of the physical locations of the patient's body including at least a portion of the patient's heart at phases &phgr;2(L) of the cardiac cycle different from &phgr;1(L) at physical positions L of interest, and determining a difference image from the acquired data representative of the first scout-scanned CT image and the acquired data representative of the second scout-scanned CT image data. It is not necessary that &phgr;1(L) and &phgr;2(L) be constant as a function of position L.