Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. He conjugates are useful to treat certain diseases, such as acromegaly.

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: An apparatus and related methods for constructing articles with cured pressure-sensitive adhesives comprising (i) a coater that applies a curable adhesive to a membrane; (ii) a cross-linking apparatus adapted to receive said membrane with said curable adhesive, said cross-linking apparatus comprising a light source positioned a first predetermined height above an aperture plate having an aperture therethrough, wherein said aperture plate is positioned a second predetermined height, said first predetermined height and said second predetermined height selected to define an exposure area of light emitted from said light source on to said curable adhesive to form a composite product; and (iii) a roll adapted to receive said composite product, said roll adapted to control a speed at which said membrane with said curable adhesive is exposed to light from said light source.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.

Abstract: A collapsible protective helmet (10) comprises an impact-resistant base body (11) intended to encircle the head of a wearer and an impact-resistant crown (12) coupled to the base body by coupling means to be movable between a protective position in which the crown is supported by the base body in an orientation in which the crown covers the top of the head of the wearer and a stored position inverted relative to the protective position in which the crown is supported by, but nested in, the base body. The helmet further comprises releasable locking means for locking the base body (11) and crown (12) together in each of the two positions of the crown.

Abstract: An apparatus (200) and method for preparing a cylindrical object having a protective surface coating, such as a necked can (100), for decorating thereon using a printing technique. According to the method, a primer is applied onto the surface coating, and the primer is then dried to form a surface for decorating the object. The apparatus comprises a priming station (260) for applying a primer onto said surface coating, and a drying station (270) for drying the primer.

Abstract: The present disclosure provides an apparatus for handling objects. The apparatus comprises a carrying device (104) that is configured to move along a track (102). A handling device (224) is adapted to hold an object (108) and is mounted to the carrying device (104) such that it is rotatable with respect to the carrying device about a handling axis (226). A drive device (310) is disposed at a position along the track (102) and configured to produce a torque around a drive axis. The carrying device (104) can be moved along the track (102) in a direction perpendicular to the drive axis into and out of a drive position. In the drive position, the handling axis (226) of the handling device (224) is in substantial alignment with the drive axis of the drive device (310) whereupon the drive device induces a torque in the handling device (224) causing the handling device to rotate, thereby causing the object (108) held by the handling device to rotate.

Abstract: The invention provides an antifungal composition comprising an antifungal compound of formula R—S+(R?)2 or R—N+(R?)3 wherein R is C17-C32 straight chain or branched alkyl; and each R? is independently methyl, ethyl, propyl, isopropyl or butyl; and uses of said composition as antifungal agents.

Abstract: Certain embodiments of the invention provide a cationic lipid of formula (I): wherein R1, R2, R3 and R4 are defined as described herein, as well as methods of making these lipids. Certain embodiments of the invention also provide nucleic acid-lipid particles comprising a cationic lipid of formula (I), methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.

Abstract: A printing system for printing on an outer surface of a tubular object is provided. The printing system comprises at least one printing station for printing on the outer surface of the tubular object (100); and at least one holding device for holding the tubular object during a printing process. The holding device comprises: a substantially annular gripper ring (200) adapted to be partially inserted into a tubular object. The gripper ring comprises a radially compressible portion (201) configured to securely engage with an inner surface of the tubular object. The radially compressible portion exerts a radially outward mechanical restoring force when compressed.

Abstract: A system for transmitting rotational motion between a driving element and a driven element comprises a driving element that is coupled to a torque input that causes the driving element to rotate about a drive axis. The driving element comprises a first magnetic element. A driven element is configured to rotate about a driven axis. The driven element comprises a second magnetic element. Both the first magnetic element and second magnetic element are susceptible to a magnetic field, and at least one of the first and second magnetic element produces a magnetic field. A magnetic interaction between the first magnetic element and the second magnetic element couples the rotational motion of the driving element and the rotational motion of the driven element. The driving and driven elements are coupled at a predetermined rotational orientation with respect to each other.

Abstract: The invention provides PEG-conjugated lipids of formula (I): A-B-C (I) wherein A, B, and C have any of the values defined in the specification, as well as compositions comprising the PEG-conjugated lipids of formula (I), nucleic acid lipid nanoparticles comprising the PEG-conjugated lipids of formula (I), and methods of using the PEG-conjugated lipids of formula (I), the compositions, and the nucleic acid nanoparticles.

Abstract: A device assembly having a syndicated data service interface that is communicatively coupled to a vendor-specific syndicated data application platform and having an installed vendor specific syndicated data application, with the interface receiving point-to-multipoint non-addressed transport bearer channels of different syndicated data channel transport networks initially only including the monitoring of the syndicated data channels and not decoding the syndicated data messages or syndicated data informational data contained therein, identifying from the transport bearer channels a received syndicated data channel having an syndicated data channel identifier of the specific syndicated data device, and reading the syndicated data messages within the received syndicated data channel and extracting the syndicated data supplier-independent informational data from the syndicated data message and providing the extracted syndicated data informational data to at least one of the installed vendor specific syndicated d

Abstract: The invention provides conjugates that comprise a bivalent targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates, compositions comprising the bidentate targeting ligands and the conjugates, as well as methods for targeting therapeutic nucleic acids with the bidentate conjugates. The conjugates are useful to target therapeutic nucleic acids.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger, and plunger driver assembly comprising double-acting, telescoping lead screws that is located behind and outside of the barrel. Simultaneously and counter-rotating sleeve screw and center screw telescope out of a nested configuration of the plunger driver assembly and into the reservoir at a rate of double their individual and equal pitch and lead parameters when the sleeve screw is rotated. A threaded nut and gear anchor disposed on an end of the barrel receive the sleeve screw and the threaded nut causes the sleeve screw to translate and rotate in response to motor operation. A distal end of the center screw can be keyed to a plunger pusher for anti-rotation constraint when the motor is imparting rotation on the threaded nut and sleeve screw.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger and plunger driver assembly comprising nested, telescopic screws comprising an innermost screw keyed to a first side of the plunger or intermediate pusher to prevent rotation. In a fully retracted position, the nested screws do not extend into the reservoir. The nested screws all have right handed threads and employ the same pitch in their respective inner thread and outer thread designs. The outermost screw is connected to a motor for controllable rotation. The decreasing torque ratios from the outermost to innermost screw member and anti-rotation feature allows the innermost screw to advance the plunger into the reservoir before the adjacent concentric screw member commences rotating and advancing within its corresponding screw, and so on, to translate the plunger and expel fluid in a fluid chamber defined on the other, second side of the plunger.

Abstract: Methods and systems for installing and verifying installation of a fastener assembly using predictive verification. A method includes receiving, at a processor, at least one fastener assembly hole characteristic of a fastener assembly hole. The method further includes determining, via the processor, whether the at least one fastener assembly hole characteristic is within a predetermined range of fastener assembly hole variable and, upon determining the at least one fastener assembly hole characteristic is within the predetermined range of fastener assembly hole variables, transmitting instructions, via the processor, to a fastening device to initiate installation of a fastener assembly in the fastener assembly hole. The processor then receives at least one installation value of the fastener assembly and determines via the processor, whether the installation value is within a predetermined range of fastener installation variables.

Abstract: An improved syndicated data system and method providing a plurality of intelligent devices with syndicated vendor-independent data from a syndication data server having informational data that is supplier-independent, formatting the received informational data into syndicated data messages, creating syndicated data channels, transmitting by broadcasting over a point-to-multipoint non-addressed transport bearer channel, with the devices monitoring the received point-to-multipoint non-addressed transport bearer channels of the different syndicated channel transport networks, identifying a received channel by comparing to the stored message or channel selection criteria to the received channel or IoT message contained therein, successful reading the syndicated data messages within the received syndicated channel, extracting the supplier-independent informational data from the syndicated data message and providing the extracted syndicated informational data to an installed vendor specific syndicated data applicat

Abstract: A device assembly having a syndicated data service interface that is communicatively coupled to a vendor-specific syndicated data application platform and having an installed vendor specific syndicated data application, with the interface receiving point-to-multipoint non-addressed transport bearer channels of different syndicated data channel transport networks initially only including the monitoring of the syndicated data channels and not decoding the syndicated data messages or syndicated data informational data contained therein, identifying from the transport bearer channels a received syndicated data channel having an syndicated data channel identifier of the specific syndicated data device, and reading the syndicated data messages within the received syndicated data channel and extracting the syndicated data supplier-independent informational data from the syndicated data message and providing the extracted syndicated data informational data to at least one of the installed vendor specific syndicated d

Abstract: A modular animal pen system comprises front and rear panels and opposed side panels extending between the front and rear panels to form a primary enclosure. The front panel has adjacent doorway apertures formed therein to receive respective selectively closable gates, and a mullion is disposed between the doorway apertures. The mullion has a first slot, and a second slot in the rear panel is in registration with the first slot. The animal pen system further comprises a removable divider panel whose longitudinal ends are sized to fit removably within the respective slots so that the divider panel can divide the primary enclosure into two secondary enclosures. The side and divider panels may be formed by interchangeable profile panels, and the front and rear panels may be formed by interchangeable face panels connectable end-to-end to form a junction slot therebetween sized to receive the longitudinal ends of the profile panels.