Abstract: Polymeric nanoparticles comprising a defined set of biologically active agents that provide for targeted stimulation of non-responsive T cells, e.g. T cells involved in cancer, are provided.

Abstract: The present invention provides a system, apparatus and method for modularly adapting a network node architecture to function in one of a plurality of potential node types. The architecture includes a configurable switching element, integrated optics, and a plurality of modules that allow a “type” of node to be adapted and configured within the base architecture. The module interfaces may be optical or electrical and be used to construct various different types of nodes including regenerators, add/drop nodes, terminal nodes, and multi-way nodes using the same base architecture.

Abstract: A digital optical network (DON) is a new approach to low-cost, more compact optical transmitter modules and optical receiver modules for deployment in optical transport networks (OTNs). One important aspect of a digital optical network is the incorporation in these modules of transmitter photonic integrated circuit (TxPIC) chips and receiver photonic integrated circuit (TxPIC) chips in lieu of discrete modulated sources and detector sources with discrete multiplexers or demultiplexers.

Abstract: A digital optical network (DON) is a new approach to low-cost, more compact optical transmitter modules and optical receiver modules for deployment in optical transport networks (OTNs). One important aspect of a digital optical network is the incorporation in these modules of transmitter photonic integrated circuit (TxPIC) chips and receiver photonic integrated circuit (TxPIC) chips in lieu of discrete modulated sources and detector sources with discrete multiplexers or demultiplexers.

Abstract: A digital optical network (DON) is a new approach to low-cost, more compact optical transmitter modules and optical receiver modules for deployment in optical transport networks (OTNs). One important aspect of a digital optical network is the incorporation in these modules of transmitter photonic integrated circuit (TxPIC) chips and receiver photonic integrated circuit (RxPIC) chips in lieu of discrete modulated sources and detector sources with discrete multiplexers or demultiplexers.

Abstract: The present invention provides a system, apparatus and method for modularly adapting a network node architecture to function in one of a plurality of potential node types. The architecture includes a configurable switching element, integrated optics, and a plurality of modules that allow a “type” of node to be adapted and configured within the base architecture. The module interfaces may be optical or electrical and be used to construct various different types of nodes including regenerators, add/drop nodes, terminal nodes, and multi-way nodes using the same base architecture.

Abstract: A method and apparatus for playing a wagering game using cards having numeric value associated therewith is disclosed. In one embodiment each player is dealt four cards which are set into a two card high hand and a two card low hand. A comparison occurs to determine one or more winning hands, tie hands, or losing hands. In one embodiment the ranking is based on, in numeric order, the highest pair, followed by the least significant digit of the numerical sum of the two or more cards with the goal being closest to be closest to nine, and finally, the case of ties, the hand having the highest ranking single card. In one embodiment the player or the player/banker must win both the front hand and the back hand to collect or win the wager.

Abstract: A method and apparatus of playing a game based on numerical outcomes is disclosed. In one embodiment, the game is played utilizing a playing surface, a pair of dice, and a marker used to indicate wagers corresponding to the realized numerical outcome. In one embodiment, the method of play comprises one or more players placing wagers on betting locations associated with numerical outcomes being realized, a dealer generating a numerical outcome, and the dealer collecting losing wagers and paying out winning wagers based on a comparison of the bets in relation to the numerical outcome. The betting locations may be grouped into a one roll region, a before a predetermined number region, an odds betting region, and a hardway betting region.

Abstract: A game based on a comparison of the numerical outcomes of one or more hands is disclosed. In one embodiment, the game is played on a gaming table having a dealer station and multiple bettor stations. In one embodiment, the method of play comprises bettors placing bets as to the outcome of a comparison between one or more hands in relation to a target value. Thereafter, a dealer deals cards to one or more hands and tracks the point values of each hand in relation to a numeric threshold. Cards are dealt to a hand until the value of the hand meets or exceeds the numeric threshold. Thereafter, a comparison between the value of each hand and the target values occurs to determine which hand is closest to the target value or if a tie has occurred. Awards are made to betters placing wagers or bets on the correct outcomes.

Abstract: A method and apparatus for wagering on a contest by making two or more event outcome selections from a group of two more events is disclosed. In one embodiment, a game card is provided having two or more event blocks containing events. A bettor submits a game card with a wager to become eligible to win a pool of wagers generated by multiple game card submissions. For the events on the game card, the bettor selects event outcomes. Upon occurrence of the contest, the event outcome selections on the game cards are compared to actual outcome resulting from the contest and points are assigned to accurate outcome selections. The game cards' point totals are compared; a bettor with the highest point totals is designated the winner. In one embodiment, the wagers are allocated to a general pool and a perfect ticket pool.

Abstract: A digital optical network (DON) is a new approach to low-cost, more compact optical transmitter modules and optical receiver modules for deployment in optical transport networks (OTNs). One important aspect of a digital optical network is the incorporation in these modules of transmitter photonic integrated circuit (TxPIC) chips and receiver photonic integrated circuit (TxPIC) chips in lieu of discrete modulated sources and detector sources with discrete multiplexers or demultiplexers.