Abstract: A novel pathogenesis underlying certain types of seizures and migraines is disclosed and the validated set of premises presented enable the deductive conclusion to be made that drugs that reduce the amount of calcium ions (Ca++) released from bone reduce seizure and migraine risk. The premises validated as true in the specifications include: 1) Known seizure and migraine triggers increase osteoclast mediated release of Ca++ from bone. 2) Increased Ca++ released from bone increases seizure and migraine risk by a) depolarization of nerve membranes, b) enhanced calcium channel mediated neurotransmitter release and increases muscle contractility by c) enhanced neurotransmitter release at the neuromuscular junction and d) enhanced removal of the tropomyosin block between actin and myosin. 3) Conversely, reducing Ca++ released from bone reduces seizure and migraine risk. 4) Cinacalcet reduces Ca++ released from bone. Therefore, cinacalcet reduces migraine risk.

Abstract: Novel etiology and pathogenesis of premenstrual headache and premenstrual migraine are presented and novel treatment methods are provided. Present invention identifies how declining estrogen results in a transient elevation in extracellular calcium concentrations via osteoclast upregulation. The elevated extracellular calcium pathogenesis is then traced, from bone to brain, and includes depolarization of nerves, hyperactive neurotransmitter release, and hyperactive muscle contractility. Treatment methods are provided that target the earliest steps of the underlying etiology, in order to provide the most efficacious treatment possible. The treatment methods presented include use of compounds such as calcitonin and SERMs such as raloxifene.

Abstract: The present invention discloses that prior art protocols that administer HER receptor blockers concurrently with phase specific cytotoxic chemotherapeutics result in antagonistic function that prevents subsequent administrations of phase specific cytotoxic from functioning. The present invention provides protocols that allow the two classes of drugs to function synergistically. Moreover, the present invention also identifies that gompertzian tumor growth results in heterogeneity of cell cycle times in a tumor and that chemotherapeutic depopulation of the tumor results in accelerating cell cycle times, both of which preclude synchronicity of successive administrations of S-Phase cytotoxics relative to the progression of the S-Phase in the cancer cell population under prior art protocols. Present invention provides novel “synchronous” protocols for S-Phase cytotoxics, using HER blockers, to overcome this problem. Present invention also discloses how to integrate protocols of U.S. Pat. No.

Abstract: The present invention discloses protocols for HER cancers that are also endocrine dependent in a manner that provides dual action by using both HER antibodies and endocrine blockers/downregulators and insures function of S-Phase cytotoxics by administration of endocrines prior to administration of the S-Phase cytotoxic.

Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation for chemical debridement of cells in the lungs of COPD patients are disclosed.

Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation to inhibit inflammatory responses in the respiratory tract are disclosed.

Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation, to inhibit proliferation of, or reduce viability of, neoplasms in the lungs are disclosed. Methods for chemical debridement of diseased cells in the lungs of COPD patients as well as inhibition of inflammatory responses in the lungs are also disclosed.

Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to achieve apoptotic ablation of internal organs or internal non-malignant cell populations are disclosed.

Abstract: The invention discloses compositions and methods for increasing chemotherapeutic specificity to endocrine dependent cancers, and reducing systemic toxicity, through administration of endocrine hormones in conjunction with administration of phase specific chemotherapeutics. The invention also discloses why prior art phase specific chemotherapeutic regimens fail to achieve high cure rates for cancer. The failure relates to the Gompertzian acceleration, or reduction in cancer cell cycle time, induced by the chemotherapeutic reduction of tumor size, which in turn results in the cancer's lack of phase synchronicity to subsequent administrations of the phase specific chemotherapeutic(s).

Abstract: A device for localized delivery of drugs into a user definable, three dimensional area within a tissue mass comprising a means for securely housing a plurality of hypodermic needles, a means of impaling and retracting the hypodermics into a tissue mass, and a means of injecting the contents of the hypodermics as they are being retracted.

Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to chemexfoliate selected epidermal cell populations are disclosed.

Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to inhibit proliferation of psoriatic cell populations in the epidermis are disclosed.

Abstract: Sesquiterpenoid compounds and method for using such compounds to inhibit proliferation of malignant cells without inducing appreciable systemic cytotoxicity are disclosed. The compositions and methods presented also greatly reduce the duration of administration regimens compared to prior art and provide novel synergistic uses in combination with prior art chemotherapeutics.

Abstract: An apparatus for culturing and harvesting fungal spores and airborne particulates made up of a culture chamber with a means of issuing positive air pressure attached to one side and a harvesting chamber attached to the opposite side with means of dissipating the positive air pressure and means of collecting fungal spores and mycotoxins. Also a hydrophilic culture device made up of a plurality or horizontal and vertical planar members residing in a pan that can be inserted in the culture chamber.

Abstract: A photography booth including a plurality of vertical and horizontal frame elements attached to one another to form a generally cylindrical frame structure capable of detachably mounting a resilient sheet of material so as to form the resilient sheet of material into a cylindrical wall segment, capable of rotationally mounting a circular floor member within the cylindrical wall segment, having a camera mounting and positioning device, and having means for positioning a plurality of adjustable light sources.

Abstract: A framework residing in a cat litter box with sprockets, chains, and chain guides allowing a blade and basket mechanism to move horizontally through a cat litter box removing the cat excrement. The blade and basket are then elevated to a point at which they dump the cat excrement into an inclined chute. The cat excrement travels down the chute and into a disposable receptacle such as a plastic bag.

Abstract: A foot actuated toilet seat lifting, anti-slamming, and reseating device that functions exceptionally well over a wide range of user foot pressure variations or abruptness. The base member is substantially a lever pivotally attached to a fulcrum. The lever has a resilient material attached at the foot receiving end, an adjustable lifting rod pivotally attached at the opposite end, and a pneumatic device adjustably and pivotally attachable in between. Both the rod and pneumatic device extend upward and are pivotally attached to the toilet seat by a bracket. The pneumatic device does not provide resistance as the seat is lifted, dampens then stops the seat at the desired lift climax preventing slamming, and then provides a gentle return of the seat without slamming even if the users foot is abruptly removed. The resilient material on the foot receiving end feels good as well as aiding damping at lift climax, and aiding in return of the seat.