Abstract: A photoionization detector includes a housing, electrical contacts within the housing and an easily removable and replaceable photoionization chamber within the housing. The photoionization chamber includes a cathodic electrode and an anodic electrode which may be coated with a thin layer of material. The photoionization chamber and the associated cathodic electrode and anodic electrode are removable from within the housing as a unit. The photoionization chamber makes electrical connection with the contacts when seated within the housing regardless of the orientation of the photoionization chamber about an axis.