Patents by Inventor Markian R. Bochan

Markian R. Bochan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pro-apoptotic bacterial vaccines to enhance cellular immune responses
    Patent number: 8481056
    Abstract: Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of enhancing antigen presentation by intracellular bacteria in a manner that improves vaccine efficacy. After identifying an enzyme that has an anti-apoptotic effect upon host cells infected by an intracellular microbe, the activity of the enzyme is reduced, thereby modifying the microbe so that it increases immunogenicity. Also, the present invention provides a method of incrementally modifying enzyme activity to produce incrementally attenuated mutants of the microbe from which an effective vaccine candidate can be selected.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: July 9, 2013
    Assignee: Vanderbilt University
    Inventors: Douglas S. Kernodle, Markian R. Bochan
  • Pro-Apoptotic Bacterial Vaccines To Enhance Cellular Immune Responses
    Publication number: 20120276144
    Abstract: Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of enhancing antigen presentation by intracellular bacteria in a manner that improves vaccine efficacy. After identifying an enzyme that has an anti-apoptotic effect upon host cells infected by an intracellular microbe, the activity of the enzyme is reduced, thereby modifying the microbe so that it increases immunogenicity. Also, the present invention provides a method of incrementally modifying enzyme activity to produce incrementally attenuated mutants of the microbe from which an effective vaccine candidate can be selected.
    Type: Application
    Filed: September 19, 2011
    Publication date: November 1, 2012
    Inventors: Douglas S. Kernodle, Markian R. Bochan
  • Pro-apoptotic bacterial vaccines to enhance cellular immune responses
    Patent number: 8021671
    Abstract: Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of enhancing antigen presentation by intracellular bacteria in a manner that improves vaccine efficacy. After identifying an enzyme that has an anti-apoptotic effect upon host cells infected by an intracellular microbe, the activity of the enzyme is reduced, thereby modifying the microbe so that it increases immunogenicity. Also, the present invention provides a method of incrementally modifying enzyme activity to produce incrementally attenuated mutants of the microbe from which an effective vaccine candidate can be selected.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: September 20, 2011
    Assignees: Vanderbilt University, The United States of America as represented by The Department of Veteran' Affairs
    Inventors: Douglas S. Kernodle, Markian R. Bochan
  • Pro-apoptotic bacterial vaccines to enhance cellular immune responses
    Publication number: 20040109875
    Abstract: Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of enhancing antigen presentation by intracellular bacteria in a manner that improves vaccine efficacy. After identifying an enzyme that has an anti-apoptotic effect upon host cells infected by an intracellular microbe, the activity of the enzyme is reduced, thereby modifying the microbe so that it increases immunogenicity. Also, the present invention provides a method of incrementally modifying enzyme activity to produce incrementally attenuated mutants of the microbe from which an effective vaccine candidate can be selected.
    Type: Application
    Filed: January 20, 2004
    Publication date: June 10, 2004
    Inventors: Douglas S. Kernodle, Markian R Bochan