Abstract: The present invention relates to a method for manufacturing coated paperboard suitable for packaging paperboard applications. The method comprises coating a first surface of the paperboard web by applying a) a first coating composition in a precoating unit for forming a precoating layer comprising inorganic mineral pigment particles and least one binder for sealing the first surface of the paperboard web; and b) a second coating composition in a curtain coating unit for forming at least one barrier coating layer on the first surface of the paperboard web; and c) a third coating composition comprising a polymer dispersion in the curtain coating unit for forming at least one heat sealable coating layer on the first surface of the paperboard web. The temperature of the coated paperboard web is controlled and adjusted, and the paperboard web is cooled in at least one cooling unit.

Abstract: Systems and methods are disclosed. An example method of determining the concentration of at least one analyte in a plurality of samples by sequentially subjecting each sample to an analysis cycle includes contacting the sample or a sample-derived solution with a sensor surface supporting a species capable of specifically binding the analyte or an analyte-binding species, detecting the amount of binding to the sensor surface, and regenerating the sensor surface to prepare it for the next analytical cycle, and based on the detected binding to the sensor surface determining the concentration of analyte in each sample using virtual calibration data calculated for each analysis cycle from real calibration data obtained by contacting the solid phase with samples containing known concentrations of analyte.

Abstract: A method of determining the concentration of at least one analyte in a plurality of samples by sequentially subjecting each sample to an analysis cycle comprises contacting the sample or a sample-derived solution with a sensor surface supporting a species capable of specifically binding the analyte or an analyte-binding species, detecting the amount of binding to the sensor surface, and regenerating the sensor surface to prepare it for the next analytical cycle, and based on the detected binding to the sensor surface determining the concentration of analyte in each sample using virtual calibration data calculated for each analysis cycle from real calibration data obtained by contacting the solid phase with samples containing known concentrations of analyte.

Abstract: A method of screening a plurality of fluid samples for the presence of species capable of specifically binding to a binding partner immobilized on a sensing surface of a sensor is disclosed. The method comprises contacting each sample with the sensing surface and a reference surface, and subjecting the sensing surface responses obtained for all samples to a computational process which comprises fitting al responses to a model equation for the relationship between a response at the sensing surface and the corresponding response at the reference surface. In an iterative process residuals above a pre-determined threshold value are removed, the model equation is adjusted, and all remaining samples are refitted to the adjusted model equation until the model equation at least substantially converges. Residuals above the predetermined threshold value are considered as species specifically binding to the binding partner.

Abstract: A method for estimating a risk of relapse of addictive behavior related to exposure to an addictive stimulus, the method including the steps of, at multiple points in time, requesting the individual to measure exposure to the stimulus or answering a questionnaire, measuring the individual's exposure to the stimulus and collecting the individual's questionnaire answers, transmitting a result from the measurement device to a central server unit, storing the result in the central server unit, estimating a risk of relapse based on a combination of the received result and historic results, determining a next point in time for requesting the individual to do at least one of conducting a measurement of the individual's exposure to the stimulus and answering a questionnaire, based on the estimated risk, and if the estimated risk is greater than a predefined level, transmitting a message to a third party informing about the estimated risk.

Abstract: The present invention relates to a method for manufacturing coated paperboard suitable for packaging paperboard applications. The method comprises coating a first surface of the paperboard web by applying a) a first coating composition in a precoating unit for forming a precoating layer comprising inorganic mineral pigment particles and least one binder for sealing the first surface of the paperboard web; and b) a second coating composition in a curtain coating unit for forming at least one barrier coating layer on the first surface of the paperboard web; and c) a third coating composition comprising a polymer dispersion in the curtain coating unit for forming at least one heat sealable coating layer on the first surface of the paperboard web. The temperature of the coated paperboard web is controlled and adjusted, and the paperboard web is cooled in at least one cooling unit.

Abstract: A method of screening a plurality of fluid samples for the presence of species capable of specifically binding to a binding partner immobilized on a sensing surface of a sensor is disclosed. The method comprises contacting each sample with the sensing surface and a reference surface, and subjecting the sensing surface responses obtained for all samples to a computational process which comprises fitting al responses to a model equation for the relationship between a response at the sensing surface and the corresponding response at the reference surface. In an iterative process residuals above a pre-determined threshold value are removed, the model equation is adjusted, and all remaining samples are refitted to the adjusted model equation until the model equation at least substantially converges. Residuals above the predetermined threshold value are considered as species specifically binding to the binding partner.

Abstract: A method of determining the concentration of at least one analyte in a plurality of samples by sequentially subjecting each sample to an analysis cycle comprises contacting the sample or a sample-derived solution with a sensor surface supporting a species capable of specifically binding the analyte or an analyte-binding species, detecting the amount of binding to the sensor surface, and regenerating the sensor surface to prepare it for the next analytical cycle, and based on the detected binding to the sensor surface determining the concentration of analyte in each sample using virtual calibration data calculated for each analysis cycle from real calibration data obtained by contacting the solid phase with samples containing known concentrations of analyte.

Abstract: A method of determining the concentration of a virus or antigen thereof in a sample comprises the steps of: providing a sensor surface having immobilized thereto a virus antigen or a virus antigen analogue, mixing the sample with a known amount of antibody to the virus antigen to obtain a predetermined concentration of antibody to the antigen in the sample mixture, contacting the sample mixture with the sensor surface to bind free antibody in the mixture to the sensor surface, measuring the response of the sensor surface to the binding of free antibody, and determining the concentration of the virus or antigen in the sample from a calibration curve prepared by measuring the responses obtained for mixtures containing the predetermined concentration of antibody and different concentrations of virus.

Abstract: A wet end of a paper or board machine has at least one vertical, self-supporting installation module (10a, 10b) to be positioned into connection with the machine which module is supported from its lower end by foundation structures of the machine construction and which extends at least to the height of a second maintenance platform (50b) of the machine, which installation module (10) includes at least valves (40) and pipes (30) related to the hydraulic and/or pneumatic actuators of the machine.

Abstract: A wet end of the machine comprises at least one vertical, self-supporting installation module (10a, 10b) to be positioned into connection with the machine which module is supported from its lower end by foundation structures of the machine construction and which extends at least to the height of a second maintenance platform (50b) of the machine, which installation module (10) includes at least valves (40) and pipes (30) related to the hydraulic and/or pneumatic actuators of the machine.

Abstract: A method for manufacturing a web of paper and paperboard, in which method a spray-coating technique is used for applying a web treatment substance to at least one surface of a moving web. The qualities of the web treatment substance are selected such that at least the droplet size and viscosity of the web treatment substance are controlled such as to make the thickness of the applied web treatment substance essentially equal in at least two randomly selected sample areas. According to the invention, the applied coating conforms with the surface contour of the base sheet. A paper manufactured using the method.

Abstract: A method and apparatus for assaying a drug candidate with a biosensor having one or more sensing surface-bound biomolecules associated therewith are disclosed. The method comprises the steps of measuring the binding interaction between the drug candidate and the one or more sensing surface-bound biomolecules of the biosensor to obtain an estimate of at least one binding interaction parameter of the drug candidate, and then comparing the estimated binding interaction parameter against a mathematical expression correlated from binding interaction data associated with known drug compounds to determine an estimate of at least pharmacokinetic parameter of absorption, distribution, metabolism, or excretion (ADME) that is related to the drug candidate. The present invention allows for the simultaneous measurement of different pharmacokinetic parameters of the drug candidate, as well as an indication of the drug candidate's solubility, by use of a single analytical instrument.

Abstract: A method and apparatus for assaying a drug candidate with a biosensor having one or more sensing surface-bound biomolecules associated therewith are disclosed. The method comprises the steps of measuring the binding interaction between the drug candidate and the one or more sensing surface-bound biomolecules of the biosensor to obtain an estimate of at least one binding interaction parameter of the drug candidate, and then comparing the estimated binding interaction parameter against a mathematical expression correlated from binding interaction data associated with known drug compounds to determine an estimate of at least pharmacokinetic parameter of absorption, distribution, metabolism, or excretion (ADME) that is related to the drug candidate. The present invention allows for the simultaneous measurement of different pharmacokinetic parameters of the drug candidate, as well as an indication of the drug candidate's solubility, by use of a single analytical instrument.

Abstract: A method is disclosed for manufacturing a web of paper and paperboard, in which method a spray-coating technique is used for applying a web treatment substance to at least one surface of a moving web. The qualities of the web treatment substance are selected such that at least the droplet size and viscosity of the web treatment substance are controlled such as to make the thickness of the applied web treatment substance essentially equal in at least two randomly selected sample areas. By the definition of the invention, this means that the applied coating conforms with the surface contour of the base sheet. The publication also discloses a paper manufactured using the method.

Abstract: A method and apparatus for assaying a drug candidate with a biosensor having one or more sensing surface-bound biomolecules associated therewith are disclosed. The method comprises the steps of measuring the binding interaction between the drug candidate and the one or more sensing surface-bound biomolecules of the biosensor to obtain an estimate of at least one binding interaction parameter of the drug candidate, and then comparing the estimated binding interaction parameter against a mathematical expression correlated from binding interaction data associated with known drug compounds to determine an estimate of at least pharmacokinetic parameter of absorption, distribution, metabolism, or excretion (ADME) that is related to the drug candidate. The present invention allows for the simultaneous measurement of different pharmacokinetic parameters of the drug candidate, as well as an indication of the drug candidate's solubility, by use of a single analytical instrument.

Abstract: Surface regeneration of affinity biosensors and characterization of biomolecules associated therewith by multivariate technique employing cocktails of regeneration agents to optimize regeneration of biosensor surface and/or characterize biomolecules associated therewith. Kits and stock solutions for use in the context of this invention, as well as associated computer algorithms are also disclosed.