Patents by Inventor Markku I. Linnoila

Markku I. Linnoila has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatization of amines for electrochemical detection
    Patent number: 4908322
    Abstract: Primary and secondary amines in biological fluids are selectively derivitized by reaction with esters of N-hydroxysuccinimide or N-hydroxysulfosuccinimide to form an N-acylated derivative. Those N-acylated derivatives may then be extracted into a polar organic phase and extracted. Non-electroactive amines may be made suitable for coulometric analysis by selecting the ester used so as to attach an electroactive group to the amine. For example, histamine may be reacted with the Bolton-Hunter reagent to form a suitable derivative in high yield.
    Type: Grant
    Filed: December 27, 1988
    Date of Patent: March 13, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kenneth A. Jacobson, Kenneth L. Kirk, Markku I. Linnoila, Thomas Miller, Kazunori Mine