Patents by Inventor Marko Blazlc

Marko Blazlc has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230272442
    Abstract: The present invention provides a 5-methylfolate producing microorganism which a) has been modified to have a decreased expression and/or activity of a polypeptide having both dihydrofolate synthase activity and folylpolyglutamate synthetase activity compared to an otherwise identical microorganism (reference microorganism); b) has been (further) modified to express a heterologous polypeptide having only dihydrofolate synthase activity; c) has been (further) modified to have an increased expression level of at least one enzyme (such as at least two, at least three, at least four, at least five, at least six, at least seven or at least eight) enzymes involved in the biosynthesis of a 5-methylfolate compared to an otherwise identical microorganism (reference microorganism); and/or d) has been (further) modified to have a decreased expression and/or activity of a polypeptide having 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity compared to an otherwise identical microorganism (ref
    Type: Application
    Filed: June 30, 2021
    Publication date: August 31, 2023
    Inventors: Mingan Shi, Xin Xiong, Jia Sun, Jing Zuo, Yunchong Xia, Zailing Zhu, Zhigang Cai, Guoying Zhang, Marko Blazlc, Tina Kogej, Gregor Kosec, Mirjan Svageij, Jaka Horvat, Stefan Fujs