Patents by Inventor Marko Derek

Marko Derek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
    Patent number: 7435805
    Abstract: The present disclosure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also relates to a process for the preparation of 11-O-alkyl macrolides and azalides by regioselective 11-O-alkylation of macrolides and azalides having a vicinal diol system, using diazoalkanes in the presence of transition-metal halides or boric acid as catalysts. In another aspect, the disclosure relates to uses of the 11-O-alkyl macrolides and azalides as antibacterial agents or intermediates for the synthesis of other antibacterial agents.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: October 14, 2008
    Assignee: GlaxpSmithkline Istrazivacki
    Inventors: Davor Kidemet, Gorjana Lazarevski, Marko Derek, Marija Leljak
  • Macrolides
    Patent number: 7262172
    Abstract: The invention relates to novel semi-synthetic macrolides of formula (I) having antibacterial activity.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: August 28, 2007
    Assignees: Glaxo Group Limited, GlaxoSmithKline istrazivacki center Zagret d.o.o.
    Inventors: Suleman Alihodzic, Andrea Berdik, Francesca Cardullo, Antun Hutinec, Gorjana Lazarevski, Sergio Lociuro, Zorica Marusic-Istuk, Stjepan Mutak, Alfonso Pozzan, Marko Derek
  • O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
    Publication number: 20050164958
    Abstract: The present disclsoure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also relates to a process for the preparation of 11-O-alkyl macrolides and azalides by regioselective 11-O-alkylation of macrolides and azalides having a vicinal diol system, using diazoalkanes in the presence of transition-metal halides or boric acid as catalysts. In another aspect, the disclosure relates to uses of the 11-O-alkyl macrolides and azalides as antibacterial agents or intermediates for the synthesis of other antibacterial agents.
    Type: Application
    Filed: May 21, 2004
    Publication date: July 28, 2005
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Davor Kidemet, Gorjana Lazarevski, Marko Derek, Marija Leljak
  • Macrolides
    Publication number: 20040254124
    Abstract: The present invention relates to a compound of formula (I) wherein R1 is hydrogen or together with R2 is oxo; R2 represents hydroxy, OC(O)XR7, OC(O)NHXR7 or R2 together with R1 is an oxo group; R3 is hydrogen or a hydroxyl protecting group; R4 is hydrogen or XR7; R5 is hydrogen, XR7,, C(O)XR7 or C(O)NHXR7; R6 is hydrogen or R5 and R6 taken together with the intervening atoms form a cyclic carbonate having the following structure and pharmaceutically acceptable salts and solvates thereof and solvates thereof; to processes for their preparation and their use in the therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.
    Type: Application
    Filed: February 25, 2004
    Publication date: December 16, 2004
    Inventors: Suleman Alihodzic, Andrea Berdik, Francesca Cardullo, Antun Hutinec, Gorjana Lazarevski, Sergio Lociuro, Zprica Marusic-Istuk, Stjepan Mutak, Alfonso Pozzan, Marko Derek