Abstract: In a first aspect, the invention relates to the use of a UV-polymerizable composition as an embedding medium for biological samples. The UV-polymerizable composition is a composition with a refractive index ranging from n=1.45 to n=1.6 after a polymerization process. In another aspect, the invention relates to a method for producing embedded biological samples using said UV-polymerizable composition and to the embedded biological samples themselves. The biological samples can be used in a wide variety of areas, such as diagnostics among others, and are suitable in particular for RNA-based diagnostics.

Abstract: The invention relates to a device for examining samples (1) in a liquid (5), comprising a movable shaft (2), to which the sample (1) is fastened, and a cuvette (4), wherein the device further comprises a bath (3), which surrounds the movable shaft (2), and wherein the bath (3) is fillable with the liquid (5), the movable shaft (2) is configured to receive the sample (1) at the upper side (24) thereof, the movable shaft (2) reaches into the cuvette (4) from below, wherein said cuvette is open at least toward the bottom and configured to be immersed into the liquid (5) in the bath (3) with the underside thereof, and, moreover, means are provided to generate a pressure difference between the interior of the cuvette (4) and the region outside of the cuvette (4) such that the fill level (21) of the liquid (5) in the cuvette (4) is adjustable. Moreover, the invention relates to a method for examining samples (1) in a liquid (5).

Abstract: In a first aspect, the invention relates to the use of a UV-polymerizable composition as an embedding medium for biological samples. The UV-polymerizable composition is a composition with a refractive index ranging from n=1.45 to n=1.6 after a polymerization process. In another aspect, the invention relates to a method for producing embedded biological samples using said UV-polymerizable composition and to the embedded biological samples themselves. The biological samples can be used in a wide variety of areas, such as diagnostics among others, and are suitable in particular for RNA-based diagnostics.

Abstract: The invention relates to a device (10; 210; 310; 410; 510) for tomographic image recording. The device comprises a sample retainer (14), a light source (12), and a detector unit (16). The light source (12) is designed to produce a pencil beam (38), which has a beam direction (40) and which passes through a sample volume of the sample retainer (14) provided in order to accommodate a sample, and has an optical control element (30), which is able to move the pencil beam (38) passing through the sample retainer (14) transversely to the beam direction (40) while the beam direction (40) remains substantially unchanged. The detector unit (16) is designed to detect at least a portion of scattered radiation (64; 64?) escaping from a section of the pencil beam (38) within the sample volume or the sample retainer (14) in a non-spatially-resolved manner.

Abstract: The invention relates to a device (10; 210; 310; 410; 510) for tomographic image recording. The device comprises a sample retainer (14), a light source (12), and a detector unit (16). The light source (12) is designed to produce a pencil beam (38), which has a beam direction (40) and which passes through a sample volume of the sample retainer (14) provided in order to accommodate a sample, and has an optical control element (30), which is able to move the pencil beam (38) passing through the sample retainer (14) transversely to the beam direction (40) while the beam direction (40) remains substantially unchanged. The detector unit (16) is designed to detect at least a portion of scattered radiation (64; 64?) escaping from a section of the pencil beam (38) within the sample volume or the sample retainer (14) in a non-spatially-resolved manner.