Patents by Inventor Marko Sysi-Aho

Marko Sysi-Aho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF CERAMIDES AND LPLs IN DIAGNOSING CVD
    Publication number: 20190086386
    Abstract: The present invention inter alia provides a method, and use thereof, of predicting CV events such as AMI, ACS, stroke, and CV death by determining the concentration of at least one ceramide of Formula I or one lysophospholipid of Formula II and/or III and at least one lysophospholipid of Formula IV, V, VI, VII and/or VIII in a biological sample and comparing those concentrations to a control. Finding an increased concentration of the at least one Formula I ceramide or Formula II and/or III lysophospholipid and a decreased concentration of the at least one Formula IV, V, VI, VII and/or VIII lysophospholipid indicates that the subject has an increased risk of developing one or more CV events. The present disclosure also provides a method, and use thereof, of diagnosing subjects suffering acute ischemia. Also provided are kits and compositions comprising the same for use in predicting and/or diagnosing CV events.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Inventors: Marko Sysi-Aho, Mika Hilvo, Kim Ekroos, Reini Hurme, Reijo Laaksonen, Virve Vaeisaenen
  • USE OF CERAMIDES AND LPLs IN DIAGNOSING CVD
    Publication number: 20170160264
    Abstract: The present invention inter alia provides a method, and use thereof, of predicting CV events such as AMI, ACS, stroke, and CV death by determining the concentration of at least one ceramide of Formula I or one lysophospholipid of Formula II and/or III and at least one lysophospholipid of Formula IV, V, VI, VII and/or VIII in a biological sample and comparing those concentrations to a control. Finding an increased concentration of the at least one Formula I ceramide or Formula II and/or III lysophospholipid and a decreased concentration of the at least one Formula IV, V, VI, VII and/or VIII lysophospholipid indicates that the subject has an increased risk of developing one or more CV events. The present disclosure also provides a method, and use thereof, of diagnosing subjects suffering acute ischemia. Also provided are kits and compositions comprising the same for use in predicting and/or diagnosing CV events.
    Type: Application
    Filed: December 7, 2016
    Publication date: June 8, 2017
    Inventors: Marko Sysi-Aho, Mika Hilvo, Kim Ekroos, Reini Hurme, Reijo Laaksonen, Virve Väisänen
  • METHOD FOR DIAGNOSING RISK OF TYPE 1 DIABETES AND FOR PREVENTING ONSET OF TYPE 1 DIABETES
    Publication number: 20130108598
    Abstract: The invention comprises methods for diagnosing the risk of onset of type 1 diabetes and for preventing the onset of type 1 diabetes. The genetic background, metabolomes, antibodies and diversity of gut microbiota of an individual can be used for diagnosis.
    Type: Application
    Filed: May 2, 2011
    Publication date: May 2, 2013
    Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTT
    Inventors: Matej Oresic, Maria Saarela, Johanna Maukonen, Marko Sysi-Aho
  • BIOFLUID METABOLITE PROFILING AS A TOOL FOR EARLY PREDICTION OF AUTOIMMUNITY AND TYPE 1 DIABETES RISK
    Publication number: 20090318392
    Abstract: The invention concerns a method for diagnosing a child's susceptibility for developing type 1 diabetes by using a serum metabolite as biomarker. The invention concerns also a method for prevention of the onset of type 1 diabetes in a child.
    Type: Application
    Filed: September 10, 2007
    Publication date: December 24, 2009
    Applicant: ZORA BIOSCIENCES OY
    Inventors: Matej Oresic, Olli Simell, Tuulikki Seppänen-Laakso, Marko Sysi-Aho