Patents by Inventor Marko Uutela
Marko Uutela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090202491Abstract: A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.Type: ApplicationFiled: December 8, 2008Publication date: August 13, 2009Inventors: Ulf Eriksson, Kari Alitalo, Marko Uutela
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Patent number: 7476654Abstract: A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.Type: GrantFiled: March 8, 2005Date of Patent: January 13, 2009Assignee: Ludwig Institute for Cancer ResearchInventors: Kari Alitalo, Ulf Eriksson, Marko Uutela
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Publication number: 20080261888Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.Type: ApplicationFiled: April 21, 2008Publication date: October 23, 2008Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
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Patent number: 7408040Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.Type: GrantFiled: May 31, 2005Date of Patent: August 5, 2008Assignees: Helsinki University Licensing, Ltd., Luddig Institute for Cancer ResearchInventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
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Publication number: 20070142282Abstract: The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.Type: ApplicationFiled: August 15, 2006Publication date: June 21, 2007Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA LTD.Inventors: Kari Alitalo, Tuomas Tammela, Salla Keskitalo, Katri Pajusola, Markku Jeltsch, Seppo Yla-Herttuala, Terhi Karpanen, Ulf Eriksson, Marko Uutela
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Publication number: 20070042413Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.Type: ApplicationFiled: August 22, 2006Publication date: February 22, 2007Applicants: Ludwig Institute for Cancer Research, Licentia Ltd.Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
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Patent number: 7148037Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.Type: GrantFiled: March 4, 2002Date of Patent: December 12, 2006Assignees: Ludwig Institute for Cancer Research, Licentia Ltd.Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
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Patent number: 7105481Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.Type: GrantFiled: October 1, 2002Date of Patent: September 12, 2006Assignees: Ludwig Institute for Cancer Research, Licentia Ltd.Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
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Publication number: 20060030695Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.Type: ApplicationFiled: May 31, 2005Publication date: February 9, 2006Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
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Publication number: 20050260161Abstract: A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.Type: ApplicationFiled: March 8, 2005Publication date: November 24, 2005Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, Licentia Ltd.Inventors: Karl Alitalo, Ulf Eriksson, Marko Uutela
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Publication number: 20050209136Abstract: PDGF-D, a new member of the PDGFVEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.Type: ApplicationFiled: March 8, 2004Publication date: September 22, 2005Applicant: Ludwig Institute for Cancer ResearchInventors: Ulf Eriksson, Marko Uutela, Kari Alitalo
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Patent number: 6706687Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, is described, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.Type: GrantFiled: November 10, 1999Date of Patent: March 16, 2004Assignees: Ludwig Institute for Cancer Research, Helsinki UniversityInventors: Ulf Eriksson, Karin Aase, Xuri Lee, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
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Publication number: 20030073637Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.Type: ApplicationFiled: October 1, 2002Publication date: April 17, 2003Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
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Publication number: 20020164687Abstract: PDGF-C, a new member of the PDGF/VEGF family of growth factors, is described, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.Type: ApplicationFiled: May 10, 2001Publication date: November 7, 2002Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin, Christer Betsholtz
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Publication number: 20020164710Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.Type: ApplicationFiled: March 4, 2002Publication date: November 7, 2002Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin