Abstract: Disclosed herein are methods of ameliorating or inhibiting critical limb ischemia or a condition associated with critical limb ischemia in a subject, whereby such methods comprise identifying a subject having a peripheral vascular disease, peripheral arterial disease, critical limb ischemia or a condition associated with critical limb ischemia and providing to said subject a composition comprising: a cell population, wherein the cell population comprises bone marrow total nucleated cells and red blood cells, an anticoagulant, and autologous plasma, wherein the composition has a viscosity of 1.5 to 5.0 centipoise (cP) measured at 37° C., wherein the composition comprises a viable cell dose and, wherein said composition is administered to said subject intramuscularly through a standard terminally-ported cannula needle, or a cannula side-ported needle or catheter comprising a plurality of ports and a closed end.