Abstract: The present invention relates to an oral thin film comprising at least one matrix polymer and at least one active pharmaceutical ingredient, wherein the at least one active pharmaceutical ingredient is an acid or a base, characterised in that the at least one active pharmaceutical ingredient is present in the form of a mixture which comprises the at least one active pharmaceutical ingredient both in the form of the free acid or base and in the form of a pharmaceutically acceptable salt, a method for producing said oral thin film, and the use of such an oral thin film as a medicament.

Abstract: An electronic communication network comprises a server platform and client data processing devices. Each client data processing device is configured to submit electronic messages to the server platform, provided with a timestamp. The server platform is configured to process incoming electronic messages strictly in a sequence corresponding to the timestamp. The electronic communication network comprising at least one switch, wherein the switch is arranged to receive electronic messages from a plurality of the client data processing devices. the switch comprises a buffer and is configured to store the electronic messages produced by the client data processing devices in the buffer, and to transfer the electronic messages in a manner sorted according to the timestamp provided to each electronic message by the time generator of the client data processing device submitting the electronic message, so that the electronic message with the oldest time is transferred first.

Abstract: An enzymatically catalyzed method for producing L-glufosinate or a phosphoester of L-glufosinate can be performed. An activated L-homoserine HA is reacted with a substrate S selected from methylphosphinic acid and the esters of methylphosphinic acid. The method makes accessible new substrates in the enzymatic production of L-glufosinate and its phosphoesters.

Abstract: An apparatus for dispensing a mixture of a diluent and an additive for sanitation, cosmetic or cleaning applications. The apparatus includes a mixing unit for creating a mixture of the diluent and the additive, a diluent supply supplying the diluent to the mixing unit, an additive supply supplying the additive to the mixing unit, an outlet for dispensing the mixture. The diluent supply includes a pump arranged to increase the pressure of the diluent before the diluent enters the mixing unit.

Abstract: A system for actively attenuating acoustic vibrations of a rail for rail traffic is provided including at least one sensor for detecting at least a vertical acoustic vibration of the rail, at least one actuator for exciting at least a vertical counter-vibration of the rail and at least one control unit communicatively connected to the at least one sensor and the at least one actuator for controlling the at least one actuator depending on the vibration detected by the sensor, the counter-vibration being adapted to destructively interfere with the detected vibration, and the at least one actuator being mechanically coupled to the rail and to a carrier element supporting the rail. Also provided is a carrier element for the system and a method for actively attenuating acoustic vibrations of a rail for rail traffic.

Abstract: The present invention relates to a method for producing a multi-layer oral thin film comprising the steps of a) providing a solution, an emulsion, a foam or a suspension comprising at least one first polymer, b) processing the solution, the emulsion, the foam or the suspension from step a) in order to obtain a polymer film, c) applying a powder comprising at least one second substance, which preferably differs from the first polymer, to the polymer film, and d) forming a composite between the polymer film and the powder applied in step c), to a multi-layer oral thin film obtainable by this method, and to the use of a multi-layer oral thin film obtainable by this method as a medicament.

Abstract: The present invention relates to a multi-layer thin film comprising at least two layers arranged one on top of the other which each comprise at least one polymer, these at least two layers being connected to one another by at least one stitched seam using at least one thread, and to a method for producing such a thin film and to the use thereof as a medicament.

Abstract: A disc brake for utility vehicles includes a brake disc, a first brake lining on a first side of the brake disc and a second brake lining on a second side of the brake disc opposite the first side. A spreading device is also provided which generates a force that moves the first and the second brake lining away from one another.

Abstract: An apparatus for dispensing a mixture of a diluent and an additive for sanitation, cosmetic or cleaning applications. The apparatus includes a mixing unit for creating a mixture of the diluent and the additive, a diluent supply supplying the diluent to the mixing unit, an additive supply supplying the additive to the mixing unit, an outlet for dispensing the mixture. The diluent supply includes a pump arranged to increase the pressure of the diluent before the diluent enters the mixing unit.

Abstract: The invention relates to crystalline folate salts. The salt consists of a folate anion and an organic cation. The folate anion is 5-methyl-(6S)-tetrahydrofolic acid, and the cation is an organic compound which is an alkanolamine selected from the group consisting of choline, N-methylaminoethanol, 2-amino-2-methylpropanol and 2-dimethylaminoethanol.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

Abstract: A flap device for a motor vehicle comprises a flap housing that can be flowed through by a gas flow; a flap shaft that is rotatably supported about an axis of rotation in the flap housing and that supports a flap for blocking, directing or throttling the gas flow; and an actuating drive for rotating the flap shaft.

Abstract: The invention relates to crystalline folate salts. The salt consists of a folate anion and an organic cation. The folate anion is 5-methyl-(6S)-tetrahydrofolic acid, and the cation is an organic compound which is an alkanolamine selected from the group consisting of choline, N-methylaminoethanol, 2-amino-2-methylpropanol and 2-dimethylaminoethanol.

Abstract: A universal quantum computing system uses electro-nuclear wavefunctions of rare-earth ions embedded in an insulating solid state matrix. Each rare-earth ion represents a nuclear qubit that can be selectively operated as a passive or active qubit. The passive qubit is a passive electronic doublet at a non-degenerate ground state that stores the quantum information in the two different nuclear spin states possible in the non-degenerate ground state causing two different passive-state electro-nuclear wavefunctions. The active qubit is an active electronic doublet at a non-degenerate excited state that stores the quantum information in the two different nuclear spin states possible in the non-degenerate excited state. A laser source generates laser pulses to optically excite the rare-earth ions from the non-degenerate ground state into the non-degenerate excited state and vice versa, to locally control the electronic dipolar interaction in a tunable manner among at least two active qubits.

Abstract: The invention relates to amorphous folate salt. The salt consists of a folate anion and an organic cation. The folate anion is selected from the group consisting of 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5,10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group arginine, choline, acetylcholine, 1,1-dimethyl-biguanidin phenylethylbiguanidin, betaine-methylester and dimethylaminoethanol. The cation is an organic compound with a complementary pharmacological activity.

Abstract: A self-regulating damper unit comprising a cylinder having a first working chamber and a second working chamber, a piston, a piston rod, and a through-hole between the first working chamber and the second working chamber. The damper unit also comprises a shiftable weight which modifies a passage cross-section of the through-hole. The shiftable weight is movably mounted such that retardation of the piston causes enlargement of the passage cross-section. A seat belt unit comprises a seat belt and the damper unit.

Abstract: The invention relates to amorphous folate salt. The salt consists of a folate anion and an organic cation. The folate anion is selected from the group consisting of 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5,10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group arginine, choline, acetylcholine, 1,1-dimethyl-biguanidin and phenylethylbiguanidin. The cation is an organic compound with a complementary pharmacological activity.

Abstract: The present invention relates to a process for producing an oral thin film comprising microparticles, comprising the steps of: a) producing a solution comprising a hydrophobic polymer, a hydrophobic pharmaceutically active ingredient and hydrophobic solvent, b1) providing a hydrophilic polymer and providing a hydrophilic solvent immiscible with the solvent from a), or b2) providing a solution comprising a hydrophilic polymer and a hydrophilic solvent immiscible with the solvent from a), c1) mixing the solution from a) with the hydrophilic polymer from b1) followed by the addition of the hydrophilic solvent from b1) immiscible with the solvent from a) to obtain an emulsion, or c2) mixing the solution from a) and the solution from b2) to obtain an emulsion, and d) spreading and drying the emulsion from c1) or c2) to obtain an oral thin film comprising microparticles.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

Abstract: The present disclosure relates to a hearing device, comprising at least one electronic component and at least two parts of a housing, at least one of them configured as a molded interconnect device comprising at least one electrically conductive trace and at least one pin seat, the molded interconnect device mechanically connected to another one of the parts of the housing or to a frame by at least one assembly pin held in the at least one pin seat, wherein the at least one assembly pin also directly or indirectly electrically connects the at least one electrically conductive trace to the at least one electronic component.