Abstract: The present invention relates to a method for the diagnosis, prognosis, risk assessment, risk stratification, monitoring, therapy guidance and/or therapy control of a fungal infection, in particular invasive fungal infections (IFI) and/or the ruling in or ruling out of an fungal infection and/or the differential diagnosis of a fungal colonization vs. an invasive fungal infection in a subject, wherein in particular the subject has an increased risk of getting or having a fungal infection and/or the subject is in a critical disease state, particularly has an existing infection and/or a state of sepsis, particularly a septic shock. The method of the invention comprises determining the level of at least one marker selected from the group of ICAM1, AHSG, CPN1, FABP1, HRG, PIGR, RAP1A, THBS1, VCL, ET-1. Furthermore, the invention relates to a diagnostic assay and a kit for carrying out the method.

Abstract: A roof cargo tray for a motor vehicle includes a loading surface, which is formed by two outer longitudinal profiles, a plurality of inner longitudinal profiles, two side profiles, a front transverse profile and a rear transverse profile. The side profiles and the transverse profiles delimit the loading surface of the roof cargo tray laterally. The inner longitudinal profiles have identical profile cross sections and include a longitudinal groove and a surface which is located opposite the longitudinal groove and is of closed design. At least one of the inner longitudinal profiles is arranged in a first orientation such that, when the roof cargo tray has been mounted on the motor vehicle, the longitudinal groove faces upward, and wherein at least one of the inner longitudinal profiles is arranged in a second orientation, which is rotated through 180° about a longitudinal axis and in which the longitudinal groove faces downward.

Abstract: A roof rack has at least one lighting device, which is arranged in a protected manner on a rack part. In order to improve the roof rack functionally and/or in respect of its appearance, the rack part includes a fairing having at least two light passage openings, which are assigned to the lighting device.

Abstract: A device for electrical and mechanical connection of a first element and a second element includes first and second connection elements and a connection module. The first connection element includes a first interface configured to be electrically and mechanically connected to the first element. The second connection element includes a second interface configured to be connected electrically and mechanically to the second element. The connection module is configured to provide an electrical and mechanical connection between a first connection region of the first connection element and a second connection region of the second connection element. The connection module is configured to passively open the electrical and mechanical connection between the first connection region of the first connection element and the second connection region of the second connection element in response to a triggering temperature being reached.

Abstract: Described herein are compositions and methods for inhibiting, degrading, knocking down or knocking out pip4k2c nucleic acids or Pip4k2c protein. Such compositions and methods are useful for treating and inhibiting the onset of cancer.

Abstract: A device for electrical and mechanical connection of a first element and a second element includes first and second connection elements and a connection module. The first connection element includes a first interface configured to be electrically and mechanically connected to the first element. The second connection element includes a second interface configured to be connected electrically and mechanically to the second element. The connection module is configured to provide an electrical and mechanical connection between a first connection region of the first connection element and a second connection region of the second connection element. The connection module is configured to passively open the electrical and mechanical connection between the first connection region of the first connection element and the second connection region of the second connection element in response to a triggering temperature being reached.

Abstract: A laminated vehicle glass has an outer glass, an intermediate layer arrangement, an inner glass, a first color carrier and a second color carrier. The outer glass is at least partly adhesively bonded to the inner glass via the intermediate layer arrangement. The first color carrier is formed as a print with a first printing ink on the inner side of the outer glass. The second color carrier is formed as a print with a printing ink or as a film and has a second color. The second color carrier is provided in at least some regions on the side of the first color carrier that faces away from the outer glass. The first color and second color are different, at least in some regions. The second color is provided in a frame-like region of the laminated vehicle glass.

Abstract: A roof rack has at least one lighting device, which is arranged in a protected manner on a rack part. In order to improve the roof rack functionally and/or in respect of its appearance, the rack part includes a fairing having at least two light passage openings, which are assigned to the lighting device.

Abstract: A roof cargo tray for a motor vehicle includes a loading surface, which is formed by two outer longitudinal profiles, a plurality of inner longitudinal profiles, two side profiles, a front transverse profile and a rear transverse profile. The side profiles and the transverse profiles delimit the loading surface of the roof cargo tray laterally. The inner longitudinal profiles have identical profile cross sections and include a longitudinal groove and a surface which is located opposite the longitudinal groove and is of closed design. At least one of the inner longitudinal profiles is arranged in a first orientation such that, when the roof cargo tray has been mounted on the motor vehicle, the longitudinal groove faces upward, and wherein at least one of the inner longitudinal profiles is arranged in a second orientation, which is rotated through 180° about a longitudinal axis and in which the longitudinal groove faces downward.

Abstract: The invention relates to a method for the diagnosis and/or risk stratification of invasive fungal infections (IFI)/invasive fungal diseases (IFD) and in particular associated with sepsis or septic shock, wherein a determination of the marker proadrenomedullin (proADM) or a partial peptide or fragment thereof, in particular midregional proadrenomedullin (MR-proADM), or contained in a marker combination (panel, cluster), is carried out from a patient to be examined. Furthermore, the invention relates to a diagnostic assay and a kit for carrying out the method.

Abstract: The invention relates to a method of controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein which comprises a minimal degron structural motif. In particular, the polypeptide sequence comprises a chimeric antigen receptor therefore the present invention is useful in methods of cell and gene therapy where the activity of the chimeric antigen receptor needs to be controlled.

Abstract: The present invention relates to a method for the diagnosis, prognosis, risk assessment, risk stratification, monitoring, therapy guidance and/or therapy control of a fungal infection, in particular invasive fungal infections (IFI) and/or the ruling in or ruling out of an fungal infection and/or the differential diagnosis of a fungal colonization vs. an invasive fungal infection in a subject, wherein in particular the subject has an increased risk of getting or having a fungal infection and/or the subject is in a critical disease state, particularly has an existing infection and/or a state of sepsis, particularly a septic shock. The method of the invention comprises determining the level of at least one marker selected from the group of ICAM1, AHSG, CPN1, FABP1, HRG, PIGR, RAP1A, THBS1, VCL, ET-1. Furthermore, the invention relates to a diagnostic assay and a kit for carrying out the method.

Abstract: A tire pressure monitoring unit is mounted on a vehicle wheel having a pressure and acceleration sensor. A method for assigning wheel positions includes pressure and acceleration data determined from the sensors. The pressure data and at least one piece of information derived from the acceleration data are transmitted wirelessly in a data telegram together with a characteristic identifier. Information concerning the reliability of the information derived from the acceleration data is acquired in the tire pressure monitoring unit on the basis of the measurements and is transmitted with the data telegram. A central evaluation unit considers a plurality of data telegrams and, taking account of data from the ABS sensors, assigns the individual tire pressure monitoring units to wheel positions. Data telegrams in which the reliability is higher receive a greater weighting, and data telegrams in which the reliability is smaller receive a smaller weighting.

Abstract: A folding top for a vehicle includes a folding top fabric for covering a vehicle interior in a closed position and opening up the vehicle interior in an open position. The folding top has an A pillar portion for mechanical connection to an A pillar of the vehicle, a C pillar portion for mechanical connection to a C pillar of the vehicle, a B pillar portion between the A pillar portion and the C pillar portion for lateral connection to a B pillar of the vehicle. A tensioning cable extends from the A pillar portion via the B pillar portion into the C pillar portion on each side of the folding top fabric in order to tension the folding top fabric in the closed position.

Abstract: The present disclosed subject matter relates to a housing for a firearm with an exchangeable barrel, comprising a bushing into which the barrel root of the exchangeable barrel may be inserted in the axial direction. The bushing has a slot in the axial direction and a clamping device for bringing the slot from a starting position into a narrowed position. The bushing is configured to receive the barrel root in a press-fitting manner when the slot is in the starting position and has a spreading device for bringing the slot from the starting position into an expanded position.

Abstract: The invention relates to a method for the diagnosis and/or risk stratification of invasive fungal infections (IFI)/invasive fungal diseases (IFD) and in particular associated with sepsis or septic shock, wherein a determination of the marker proadrenomedullin (proADM) or a partial peptide or fragment thereof, in particular midregional proadrenomedullin (MR-proADM), or contained in a marker combination (panel, cluster), is carried out from a patient to be examined. Furthermore, the invention relates to a diagnostic assay and a kit for carrying out the method.

Abstract: A laminated vehicle glass has an outer glass, an intermediate layer arrangement, an inner glass, a first color carrier and a second color carrier. The outer glass is at least partly adhesively bonded to the inner glass via the intermediate layer arrangement. The first color carrier is formed as a print with a first printing ink on the inner side of the outer glass. The second color carrier is formed as a print with a printing ink or as a film and has a second color. The second color carrier is provided in at least some regions on the side of the first color carrier that faces away from the outer glass. The first color and second color are different, at least in some regions. The second color is provided in a frame-like region of the laminated vehicle glass.

Abstract: The invention relates to a method of controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein which comprises a minimal degron structural motif. In particular, the polypeptide sequence comprises a chimeric antigen receptor therefore the present invention is useful in methods of cell and gene therapy where the activity of the chimeric antigen receptor needs to be controlled.

Abstract: The invention relates to a method of controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein which comprises a minimal degron structural motif. In particular, the polypeptide sequence comprises a chimeric antigen receptor therefore the present invention is useful in methods of cell and gene therapy where the activity of the chimeric antigen receptor needs to be controlled.

Abstract: A folding top for a vehicle includes a folding top fabric for covering a vehicle interior in a closed position and opening up the vehicle interior in an open position. The folding top has an A pillar portion for mechanical connection to an A pillar of the vehicle, a C pillar portion for mechanical connection to a C pillar of the vehicle, a B pillar portion between the A pillar portion and the C pillar portion for lateral connection to a B pillar of the vehicle. A tensioning cable extends from the A pillar portion via the B pillar portion into the C pillar portion on each side of the folding top fabric in order to tension the folding top fabric in the closed position.