Patents by Inventor Markus Berberich
Markus Berberich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10481054Abstract: The invention relates to a method for embedding a tissue sample into an embedding medium. In a first step the tissue sample is held in an intended orientation in a container by means of a holding element that presses the tissue sample against a base of the container. In a further step a liquid embedding medium that has a temperature above 64 degrees Celsius, in particular in the range from 65 degrees Celsius to 67 degrees Celsius, or a temperature of 66 degrees Celsius, is poured into the container, and the base of the container is cooled.Type: GrantFiled: September 1, 2016Date of Patent: November 19, 2019Assignee: Leica Biosystems Nussloch GmbHInventors: Florian Böhl, Ralf Eckert, Karin Flieger, Markus Berberich, Hermann Ulbrich, Stella Knorr, Andrew Guy
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Patent number: 10345202Abstract: A method (100) for fixing at least one tissue sample (1) is carried out using a tissue processor (10). The tissue sample (1) is introduced at a first temperature level and a first pressure level into a fixing reagent (2) containing at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of at least one aldehyde. The tissue sample (1) is left in the fixing reagent (2) for a fixing time period during which the fixing reagent (2) is brought to a second temperature level above the first temperature level and/or to a second pressure level above the first pressure level. A concentration in the fixing reagent (2) of the nitrogen-containing compound is ascertained using at least one concentration measuring device (14) of the tissue processor (10), and a signal is outputted on the basis of a measured value of the at least one concentration measuring device (14).Type: GrantFiled: November 4, 2014Date of Patent: July 9, 2019Assignee: Leica Biosystems Nussloch GmbHInventors: Hermann Ulbrich, Markus Berberich
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Patent number: 10345198Abstract: A method of producing thin sections using a microtome is disclosed. A hand wheel (32) is manually driven for producing a first thin section, and wherein the rotational movement of the hand wheel (32) is detected by an encoder (38), and a profile of the rotational movement is determined. The determined profile is stored and selected for production of at least a second thin section. A motor (24) is driven for generating a cutting movement between a cutting unit (16) and a sample holder (12) in accordance with the respective stored profile selected for producing the second thin section. A microtome (10) to carry out this method is also disclosed.Type: GrantFiled: August 18, 2014Date of Patent: July 9, 2019Assignee: Leica Biosystems Nussloch GmbHInventors: Roland Walter, Markus Berberich, Markus Wittman
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Patent number: 10060839Abstract: An automated embedding machine includes at least a conveyor, a pouring station, and a cooling station. The conveyor is embodied and arranged to receive casting molds each having at least one histological sample arranged therein, and to transport them to the pouring station which fills each casting mold with an embedding medium heated to above its melting point, and then to the cooling station which cools the embedding medium of each casting mold to below its melting point. The disclosure furthermore relates to a method for embedding a histological sample.Type: GrantFiled: April 27, 2017Date of Patent: August 28, 2018Assignee: Leica Biosystems Nussloch GmbHInventor: Markus Berberich
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Patent number: 10054364Abstract: The invention relates to a melting apparatus (100) for melting paraffin (1), having: a melting container (110) for receiving paraffin (1) to be melted; a storage container (190) for storing molten paraffin (4); having a melting container heating device (120) for heating the melting container (110), having a storage container heating device (191) for heating the storage container (190), having a fluid connection (113) fluidically connecting the melting container (110) and the storage container; the melting container (110), the storage container (190), and the fluid connection (113) being arranged so that molten paraffin (4) flows out of the melting container (110) into the storage container (190).Type: GrantFiled: February 17, 2017Date of Patent: August 21, 2018Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Hermann Ulbrich, Florian Böhl, Ralf Eckert, Karin Flieger
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Patent number: 9918405Abstract: A sample cooling device for histological samples is connectable to a power network for supplying electrical voltage to the device. The sample cooling device comprises a measuring apparatus for measuring a magnitude of an input line voltage present at the sample cooling device, and a transformer having a primary coil that comprises at least three coil pickoffs, and a secondary coil. The sample cooling device further comprises a switching means that connects two of the coil pickoffs to the power network as a function of the magnitude of the input line voltage, so that a magnitude of an output voltage present at the secondary coil has a predefined or predefinable voltage value irrespective of the magnitude of the input voltage. A corresponding method for supplying electrical power to a sample cooling device for histological samples is also disclosed.Type: GrantFiled: June 3, 2014Date of Patent: March 13, 2018Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Michael Eberhard
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Patent number: 9885641Abstract: The invention relates inter alia to an automated stainer for staining, in particular for hemalum-eosin (HE) staining, of a histological sample, the automated stainer exposing the sample to the action of at least one stain using at least one staining parameter. The automated stainer is notable for the fact that the automated stainer comprises an input means with which a staining parameter is definable, in particular is inputtable or is selectable from a plurality of possible staining parameters; and that a control apparatus is present which, upon application of the defined staining parameter, ascertains the prospectively expectable outcome of an action and displays it to the user with a display apparatus, before the automated stainer actually stains the sample.Type: GrantFiled: September 12, 2016Date of Patent: February 6, 2018Assignee: Leica Biosystems Nussloch GmbHInventor: Markus Berberich
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Publication number: 20170241712Abstract: The invention relates to a melting apparatus (100) for melting paraffin (1), having: a melting container (110) for receiving paraffin (1) to be melted; a storage container (190) for storing molten paraffin (4); having a melting container heating device (120) for heating the melting container (110), having a storage container heating device (191) for heating the storage container (190), having a fluid connection (113) fluidically connecting the melting container (110) and the storage container; the melting container (110), the storage container (190), and the fluid connection (113) being arranged so that molten paraffin (4) flows out of the melting container (110) into the storage container (190).Type: ApplicationFiled: February 17, 2017Publication date: August 24, 2017Inventors: Markus BERBERICH, Hermann ULBRICH, Florian BÖHL, Ralf ECKERT, Karin FLIEGER
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Patent number: 9733163Abstract: The present invention relates to a holding apparatus (10) for receiving specimen slides (1), having a holder (3, 4, 5) for handling the holding apparatus (10) and having at least two identification units (2a, 2b) that make available different information items to enable characterization of the orientation of the holding apparatus (10) in a stainer or coverslipper.Type: GrantFiled: March 10, 2016Date of Patent: August 15, 2017Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Christian Wilke, Jurgen Tenhaef
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Publication number: 20170227431Abstract: An automated embedding machine includes at least a conveyor, a pouring station, and a cooling station. The conveyor is embodied and arranged to receive casting molds each having at least one histological sample arranged therein, and to transport them to the pouring station which fills each casting mold with an embedding medium heated to above its melting point, and then to the cooling station which cools the embedding medium of each casting mold to below its melting point. The disclosure furthermore relates to a method for embedding a histological sample.Type: ApplicationFiled: April 27, 2017Publication date: August 10, 2017Inventor: Markus Berberich
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Patent number: 9671322Abstract: An automated embedding machine includes at least a conveyor, a pouring station, and a cooling station. The conveyor is embodied and arranged to receive casting molds each having at least one histological sample arranged therein, and to transport them to the pouring station which fills each casting mold with an embedding medium heated to above its melting point, and then to the cooling station which cools the embedding medium of each casting mold to below its melting point. The disclosure furthermore relates to a method for embedding a histological sample.Type: GrantFiled: November 25, 2014Date of Patent: June 6, 2017Assignee: Leica Biosystems Nussloch GmbHInventor: Markus Berberich
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Publication number: 20170067804Abstract: The invention relates to a method for embedding a tissue sample into an embedding medium. In a first step the tissue sample is held in an intended orientation in a container by means of a holding element that presses the tissue sample against a base of the container. In a further step a liquid embedding medium that has a temperature above 64 degrees Celsius, in particular in the range from 65 degrees Celsius to 67 degrees Celsius, or a temperature of 66 degrees Celsius, is poured into the container, and the base of the container is cooled.Type: ApplicationFiled: September 1, 2016Publication date: March 9, 2017Inventors: Florian Böhl, Ralf Eckert, Karin Flieger, Markus Berberich, Hermann Ulbrich, Stella Knorr, Andrew Guy
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Patent number: 9568402Abstract: The disclosure relates to a processor for processing histological samples. The processor comprises an inlet for insertion of a closed fixing container having the samples present therein.Type: GrantFiled: December 22, 2013Date of Patent: February 14, 2017Assignee: Leica Biosystems Nussloch GmbHInventors: Ralf Eckert, Markus Berberich, Hermann Ulbrich
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Publication number: 20160377515Abstract: The invention relates inter alia to an automated stainer for staining, in particular for hemalum-eosin (HE) staining, of a histological sample, the automated stainer exposing the sample to the action of at least one stain using at least one staining parameter. The automated stainer is notable for the fact that the automated stainer comprises an input means with which a staining parameter is definable, in particular is inputtable or is selectable from a plurality of possible staining parameters; and that a control apparatus is present which, upon application of the defined staining parameter, ascertains the prospectively expectable outcome of an action and displays it to the user with a display apparatus, before the automated stainer actually stains the sample.Type: ApplicationFiled: September 12, 2016Publication date: December 29, 2016Inventor: Markus Berberich
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Patent number: 9464970Abstract: The invention relates inter alia to an automated stainer for staining, in particular for hemalum-eosin (HE) staining, of a histological sample, the automated stainer exposing the sample to the action of at least one stain using at least one staining parameter. The automated stainer is notable for the fact that the automated stainer comprises an input means with which a staining parameter is definable, in particular is inputtable or is selectable from a plurality of possible staining parameters; and that a control apparatus is present which, upon application of the defined staining parameter, ascertains the prospectively expectable outcome of an action and displays it to the user with a display apparatus, before the automated stainer actually stains the sample.Type: GrantFiled: September 10, 2013Date of Patent: October 11, 2016Assignee: Leica Biosystems Nussloch GmbHInventor: Markus Berberich
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Publication number: 20160245728Abstract: The present invention relates to a method of producing thin sections by means of a microtome, wherein a hand wheel (32) is manually driven for producing a first thin section, and wherein the rotational movement of the hand wheel (32) is detected by means of an encoder (38), and a profile of the rotational movement is determined. The determined profile is stored and selected for production of at least a second thin section. A motor (24) is driven for generating a cutting movement between a cutting unit (16) and a sample holder (12) in accordance with the respective stored profile selected for producing the second thin section. The invention further relates to a microtome (10) by means of which the above method is carried out.Type: ApplicationFiled: August 18, 2014Publication date: August 25, 2016Inventors: Roland WALTER, Markus BERBERICH, Markus WITTMAN
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Publication number: 20160187236Abstract: The present invention relates to a holding apparatus (10) for receiving specimen slides (1), having a holder (3, 4, 5) for handling the holding apparatus (10) and having at least two identification units (2a, 2b) that make available different information items to enable characterization of the orientation of the holding apparatus (10) in a stainer or coverslipper.Type: ApplicationFiled: March 10, 2016Publication date: June 30, 2016Inventors: Markus BERBERICH, Christian WILKE, Jurgen TENHAEF
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Patent number: 9345260Abstract: The present invention relates to a method for producing a nonalcoholic beverage by fermentation, comprising the following steps: (a) providing a providing a macerated cereal extract, (b) producing a wort from the cereal extract, (c) treating the wort from step (b) with Lactobacillus microorganisms in order to obtain a sour wort, (d) mixing the sour wort from step (c) with a liquid containing sugar and treating the mixture with Lactobacillus microorganisms in order to obtain a fermented beverage, (e) heating the fermented beverage obtained from step (d) and then cooling said fermented beverage, (f) mixing the beverage, and (g) performing further treatment steps for stabilizing, clarifying, and completing the beverage.Type: GrantFiled: April 30, 2010Date of Patent: May 24, 2016Assignee: FINE FOOD & BEVERAGES GMBHInventors: Markus Berberich, Frank Lucas, Christoph Puttnies, Oliver Nordmann
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Patent number: 9322754Abstract: The present invention relates to a holding apparatus (10) for receiving specimen slides (1), having a holder (3, 4, 5) for handling the holding apparatus (10) and having at least two identification units (2a, 2b) that make available different information items to enable characterization of the orientation of the holding apparatus (10) in a stainer or coverslipper.Type: GrantFiled: December 7, 2011Date of Patent: April 26, 2016Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Christian Wilke, Jürgen Tenhaef
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Patent number: 9274034Abstract: The invention relates to a processing apparatus (100) for processing tissue samples, having a control unit (140) configured to control at least one apparatus function of the processing apparatus (100); and a communication device (130, 135) configured to read at least one information item from a user identification unit (151, 152, 153) and convey the at least one information item to the control unit (140). The control unit (140) is configured to control the at least one apparatus function of the processing apparatus (100) based on the at least one information item conveyed.Type: GrantFiled: September 5, 2013Date of Patent: March 1, 2016Assignee: Leica Biosystems Nussloch GmbHInventor: Markus Berberich