Abstract: The present invention relates to a new class of compounds of general formula (I), to the metal chelates with a metal ion suitable for computed tomography thereof, to the Gd3+ chelate complexes thereof, to methods of preparing said compounds, and to the use of said compounds as contrast agents in diagnostic imaging, such as in magnetic resonance imaging (MRI) and computed tomography (CT).

Abstract: The present invention relates to pharmaceutical compositions comprising contrast agents, to methods for preparing said pharmaceutical compositions and to their use for radiological imaging.

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: The invention relates to a fuel cell stack (10) having a plurality of fuel cells (20) which have an inlet-side cathode port (22), anode port (24) and coolant port (26) and an outlet-side cathode port (23), anode port (25) and coolant port (27), wherein the fuel cell stack (10) also has: two end plates (30, 31) between which the plurality of fuel cells (20) are arranged, wherein at least one of the end plates (30, 31) has inlet openings (32, 34, 36) and outlet openings (33, 35, 37) for a cathode gas, an anode gas and a coolant, which are each fluidically connected to the inlet-side and outlet-side cathode ports (22, 23), anode ports (24, 25) and coolant ports (26, 27), and at least one sensor (50) which is guided through at least one additional opening (39) in at least one of the end plates (30, 31) into one of the inlet-side or outlet-side cathode ports (22, 23), anode ports (24, 25) or coolant ports (26, 27). The invention also relates to a method for producing the fuel cell stack (10).

Abstract: The invention relates to a fuel cell unit as a fuel cell stack for the electrochemical generation of electrical energy, comprising stacked fuel cells, the fuel cells each comprising a proton exchange membrane, an anode, a cathode, a gas diffusion layer, a bipolar plate (10) with three separate channel structures (29) with channels for the separate passage of oxidising agents, fuel and cooling fluid.

Abstract: An aqueous pharmaceutical composition including compound having the formula of tetragadolinium [4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]-9,9-bis({[({2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propanoyl}amino)acetyl]amino}methyl)-4,7,11,14-tetraazaheptadecan-2-yl}-1,4,7,10-tetraazacyclododecan-1-yl]acetate wherein the stereochemistry at the chiral carbon of the four alanine substituents is selected from the group consisting of RRRR, SSSS, RSSS, RRSS, and RRRS stereoisomers, and racemic and diastereomeric mixtures of any thereof, or a tautomer, a hydrate, a solvate, or a salt thereof, or a mixture of same is described. The compounds may be used as an MRI contrast imaging agent.

Abstract: The invention relates to a water electrolyzer system (1) for producing hydrogen. According to the invention, the water electrolyzer system (1) comprises an electrolysis stack (8) for converting water into hydrogen, a power electronics means (12) for transforming the alternating current into a direct current in order to supply the electrolysis stack (8), components (56, 64, 72, 80) for preparing the process media supplied to and discharged from the electrolysis stack (8), and a control unit (18) for controlling the electrolysis stack (8), as well as the power electronics means (12) and the components (56, 64, 72, 80) for preparing the media. At least the electrolysis stack (8), the power electronics means (12), and the control unit (18) are formed together as an electrolyzer module (36), and the components (56, 64, 72, 80) for preparing and conveying the media are formed together as a process module (52).

Abstract: A compound represented by Formula (1) can be used as a prolonged ectoparasite-controlling agent for an animal. A preparation for systemic application for use in prolonged control of an ectoparasite in an animal include the compound. A method for prolonged control of an ectoparasite on an animal includes systemically applying the compound. The compound may be used for preparing a medicament for prolonged control of an ectoparasite on an animal. A horticultural or agricultural insecticide containing the compound, and a method of protecting a crop from a harmful organism is also provided.

Abstract: The invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, and associated methods of treating cancer.

Abstract: A screw part with an annular cross-section and having a base element that is hollow, cylindrical and at least partially injection-molded from a plasticized polymeric mass containing fibers. The base element includes at least one internal and/or external thread and an inner channel for arranging and/or passing through a conduit system element. The inner channel has at least one sealing section for sealing with the conduit system element and/or at least one support section for supporting and/or guiding the conduit system element and/or at least one retaining section for directly or indirectly locking the conduit system element. An insertion sleeve is arranged in the base element coaxially with the inner channel. The insertion sleeve is at least partially encapsulated by the polymeric mass with the polymeric mass facing radially towards the inner channel and radially away from the inner channel. A process for manufacturing such a screw part.

Abstract: Compounds of formula (I), formula (I), processes for their production and their use as pharmaceuticals.

Abstract: An aqueous pharmaceutical composition including compound having the formula of tetragadolinium[4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]-9,9-bis({[({2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propanoyl}amino)acetyl]amino}methyl)-4,7,11,14-tetraazaheptadecan-2-yl}-1,4,7,10-tetraazacyclododecan-1-yl]acetate wherein the stereochemistry at the chiral carbon of the four alanine substituents is selected from the group consisting of RRRR, SSSS, RSSS, RRSS, and RRRS stereoisomers, and racemic and diastereomeric mixtures of any thereof, or a tautomer, a hydrate, a solvate, or a salt thereof, or a mixture of same is described. The compounds may be used as an MRI contrast imaging agent.

Abstract: A diaphragm seal includes: a metallic diaphragm seal body; a dividing diaphragm; a dividing diaphragm chamber closed by the dividing diaphragm; a hydraulic channel extending, at least in sections, through the diaphragm seal body and communicating with the dividing diaphragm chamber, wherein the hydraulic channel and the dividing diaphragm chamber are filled with a transmission fluid; a filling channel, communicating with the hydraulic channel; and a closure body, which closes the filling channel, is introduced into the latter with a locating fit, and is welded to the diaphragm seal body, wherein the diaphragm seal body comprises a first material with a first degree of hardness, and the closure body comprises a second material with a second degree of hardness, which differs from the first degree of hardness by at least 10% of the lower one of the two degrees of hardness.

Abstract: The present invention relates to an arc flash protection glove (100, 200). The glove (100, 200) comprises a fire-resistant glove liner (2), which glove liner (2) consists of a palm side (3) and a back side (4), which palm side (3) comprises palm side finger portions (3A), a palm side center portion (3B) and a palm side cuff portion (3C), which backside (4) comprises backside finger portions (4A), a backside center portion (4B) and a backside cuff portion (4C).

Abstract: Compounds of formula (I), processes for their production and their use as pharmaceuticals are described herein.

Abstract: The present invention relates to a new class of compounds of general formula (I), the Gd3+ chelate complexes thereof, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

Abstract: A screw part with an annular cross-section and having a base element that is hollow, cylindrical and at least partially injection-molded from a plasticized polymeric mass containing fibers. The base element includes at least one internal and/or external thread and an inner channel for arranging and/or passing through a conduit system element. The inner channel has at least one sealing section for sealing with the conduit system element and/or at least one support section for supporting and/or guiding the conduit system element and/or at least one retaining section for directly or indirectly locking the conduit system element. An insertion sleeve is arranged in the base element coaxially with the inner channel. The insertion sleeve is at least partially encapsulated by the polymeric mass with the polymeric mass facing radially towards the inner channel and radially away from the inner channel. A process for manufacturing such a screw part.

Abstract: Compounds of formula (I) processes for their production and their use as pharmaceuticals.

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.