Patents by Inventor Markus Gräfe

Markus Gräfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11454541
    Abstract: A system and method is provided for imaging and/or spectroscopy involving generation of a first signal field and a first idler field, illumination of the object with the first idler field, generation of second signal field and a second idler field, combination of the first and second idler fields, such that the two fields are indistinguishable, combination of the first and second signal fields, such that the two fields interfere, first measurement of the interfered signal field by a detection means, one or more additional measurements of the interfered signal field, wherein for each additional measurement a different phase shift is generated in the setup, and wherein all measurements are carried out within the stability time of the setup, and calculation of a phase function.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: September 27, 2022
    Inventors: Fabian Steinlechner, Marta Gilaberte Basset, Markus Gräfe
  • Patent number: 11371932
    Abstract: An optical assembly for the illumination and hyperspectral evaluation of an object, having a light source or an optical element at which a light source radiates, wherein the light source or the optical element is designed to divide pairs of unambiguously assignable photons into a first light beam and a second light beam so that the first light beam hits a first detector system and the second light beam is directed at an object and light radiation coming from the object is directed at an optical element which spectrally decomposes light radiation and, from the optical element spectrally decomposing said light radiation, is directed at a second detector system. The first light beam can also be directed at a spectrally decomposing optical element and, from there, at a first detector system, and the light radiation coming from the object can be directed directly at the second detector system.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 28, 2022
    Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V., FRIEDRICH-SCHILLER-UNIVERSITAET
    Inventors: Falk Eilenberger, Markus Graefe, Frank Setzpfandt, Thomas Pertsch
  • Publication number: 20220034812
    Abstract: An optical arrangement for fluorescence microscopy applications. Electromagnetic radiation from a radiation source is directed onto a biological sample in the form of a light sheet. One of more fluorophore(s) is contained in the sample. The radiation photoactivates the fluorophore(s) by exciting them from a state which they cannot be exited to fluoresce to a state which they can be exited to fluoresce by illuminating with electromagnetic radiation of a particular wavelength, and subsequently photodeactivating them. Multiphoton beams of nonclassical light are directed onto a first optical system the beam(s) are directed onto a sample of the light sheet. Fluorescent radiation of fluorophores, can be excited within the light sheet by the plurality of multiphoton beams occurring simultaneously on/in the sample. The fluorescence radiation occurs by means of a second optical system on a detection system which measures in a spatially resolving manner.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 3, 2022
    Applicants: Fraunhofer-Gesellschaft Zur Foerderung Angewandten Forschung E.V., Friedrich-Schiller-Universitaet Jena
    Inventors: Markus GRAEFE, Marta GILABERTE BASSET, Falk EILENBERGER, Frank SETZPFAND
  • Publication number: 20220034813
    Abstract: In the optical arrangement for fluorescent microscopic applications, one or more multiphoton beams, but at least one or two photon pair beams, from a source of non-classical light is/are directed at a first optical system, consisting of an arrangement of at least one lens or one photon-reflecting element or another beam-forming element or a combination thereof. The first optical system (3) is designed to shape the non-classical light into a light sheet (4) or a light sheet-like shape and thence to direct it at a specimen (5), so that fluorescent radiation is excited by means of multiphoton absorption using the multiple multiphoton beams that are simultaneously incident on/in the specimen. Fluorescent radiation (6) obtained by excitation is incident by means of a second optical system (7) on a detection system (8) that is designed for the spatially resolved capture of fluorescent radiation.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 3, 2022
    Applicants: Fraunhofer-Gesellschaft Zur Foerderung Angewandten Forschung E.V., Friedrich-Schiller-Universitaet Jena
    Inventors: Markus GRAEFE, Marta GILABERTE BASSET, Falk EILENBERGER, Frank SETZPFAND
  • Publication number: 20210270671
    Abstract: A system and method is provided for imaging and/or spectroscopy involving generation of a first signal field and a first idler field, illumination of the object with the first idler field, generation of second signal field and a second idler field, combination of the first and second idler fields, such that the two fields are indistinguishable, combination of the first and second signal fields, such that the two fields interfere, first measurement of the interfered signal field by a detection means, one or more additional measurements of the interfered signal field, wherein for each additional measurement a different phase shift is generated in the setup, and wherein all measurements are carried out within the stability time of the setup, and calculation of a phase function.
    Type: Application
    Filed: February 22, 2021
    Publication date: September 2, 2021
    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Fabian Steinlechner, Marta Gilaberte Basset, Markus Gräfe
  • Publication number: 20210255096
    Abstract: The invention relates to the optical assembly for the illumination and hyperspectral evaluation of an object, having a light source or an optical element (1) at which a light source radiates, wherein the light source or the optical element is designed to divide pairs of unambiguously assignable photons into a first light beam (2) and a second light beam (5) in such a way that the first light beam hits a first detector system (4) and the second light beam is directed at an object (7) and light radiation coming from the object is directed at an optical element (8) which spectrally decomposes said light radiation and, from the optical element spectrally decomposing said light radiation is directed at a second detector system (9). The first light beam can also be directed at a spectrally decomposing optical element and from there, at a first detector system, and the light radiation coming from the object can be directed directly at the second detector system.
    Type: Application
    Filed: June 27, 2019
    Publication date: August 19, 2021
    Applicants: Fraunhofer-Gesellschaft zur Foerderung Der Angewandten Forschung E.V., Friedrich-Schiller-Universitaet
    Inventors: Falk EILENBERGER, Markus GRAEFE, Frank SETZPFANDT, Thomas PRETSCH