Patents by Inventor Markus Grosse

Markus Grosse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing biperiden IV
    Patent number: 7501519
    Abstract: The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: March 10, 2009
    Assignee: Abbott GmbH & Co., KG
    Inventors: Markus Grosse, Klaus Martin Weber, Marco Thyes, Peter Klein, Elmar Vilsmaier
  • Method for the production of biperidin
    Patent number: 7030247
    Abstract: The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol, whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride, isolation of said hydrochloride, reconversion to the free base and crystallization of said biperiden.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: April 18, 2006
    Assignee: Abbott GmbH & Co. DG
    Inventors: Peter Klein, Marco Thyes, Markus Grosse, Klaus Martin Weber
  • Method for the production of biperiden II
    Patent number: 6835839
    Abstract: The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: December 28, 2004
    Assignee: Abbott GmbH & Co. KG
    Inventors: Peter Klein, Marco Thyes, Markus Grosse, Klaus Martin Weber, Elmar Vilsmaier
  • Method for producing biperiden iv
    Publication number: 20040186294
    Abstract: The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.
    Type: Application
    Filed: May 3, 2004
    Publication date: September 23, 2004
    Inventors: Markus Grosse, Klaus Martin Weber, Marco Thyes, Peter Klein, Elmar Vilsmaier
  • Method for the production of biperiden II
    Publication number: 20040152899
    Abstract: The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.
    Type: Application
    Filed: April 5, 2004
    Publication date: August 5, 2004
    Inventors: Peter Klein, Marco Thyes, Markus Grosse, Klaus Martin Weber, Elmar Vilsmaier
  • Method for the production of biperidin
    Publication number: 20040147753
    Abstract: The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol, whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride, isolation of said hydrochloride, reconversion to the free base and crystallization of said biperiden.
    Type: Application
    Filed: March 29, 2004
    Publication date: July 29, 2004
    Inventors: Peter Klein, Marco Thyes, Markus Grosse, Klaus Martin Weber